Simple adaptive PI controller development and evaluation for mean arterial pressure regulation

Silva, Samuel Justino da; Scardovelli, Terigi Augusto; Boschi, Silvia Regina Matos da Silva; Rodrigues, Silvia Cristina Martini; Silva, Alessandro Pereira da

doi:10.1007/s42600-019-00017-y

Cited by 10 publications

(7 citation statements)

References 16 publications

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“…The mathematical model for this development is presented in Fig. 1, based on the studies of Silva et al [10] and Luspay and Grigoriadis [12].…”

Section: Model Developmentmentioning

confidence: 99%

“…Since this professional usually has other tasks to do, it is difficulty to guarantee the correction of the dosage in the right frequency [9]. Automatic control in drug administration process has been a topic of research in bioengineering since the 1980s [10]. Previous experiences point to the pharmacological variability of the response of different patients to the same drug.…”

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confidence: 99%

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Real‐time simulation device for mean arterial pressure of hypotensive patient subjected phenylephrine infusion

et al. 2020

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This Letter presents the implementation in a hardware device of the mean arterial pressure (MAP) response model of patients subjected to the infusion of the vasoconstrictor drug phenylephrine, enabling the development of automatic control systems in the future. The proposed model was firstly developed in a software platform with Simulink/MatLab using block libraries based on previous research carried out with animals and then implemented on hardware using a single‐board computer with microcontroller and code generated in C/C++. The responses of MAP were simulated and compared using the proposed software and hardware model, considering the dynamic effects of several patients. The results showed that the hardware model presented 0.43% as the largest absolute percentage error observed in all trials, for an injection rate of the drug varying in steps with levels of 40 ml/h

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“…The mathematical model for this development is presented in Fig. 1, based on the studies of Silva et al [10] and Luspay and Grigoriadis [12].…”

Section: Model Developmentmentioning

confidence: 99%

mentioning

confidence: 99%

Real‐time simulation device for mean arterial pressure of hypotensive patient subjected phenylephrine infusion

et al. 2020

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“…Intelligent control techniques like fuzzy logic controllers require some intricate rule based algorithms 8,18,19 . The model predictive control (MPC) and adaptive control techniques are computationally exhaustive 16,17 . Looking at the literature, it can be inferred that there are certain merits and demerits associated with each of these controllers in regulating the blood pressure.…”

Section: Introductionmentioning

confidence: 99%

Automatic drug infusion control based on metaheuristic H₂ optimal theory for regulating the mean arterial blood pressure

Pachauri

Begum

2021

Asia-Pacific J Chem Eng

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The primary intent of this article is to explicate the development of an efficient control strategy to enhance the automated drug infusion technique and thereby, regulating the mean arterial blood pressure (MABP) in both surgical and post‐surgical clinical scenarios. To simplify the already existing design techniques that are mathematically very complicated, a governed drug management system is required to normalize the MABP. This manuscript introduces a two degrees of freedom (2‐DOF) H2 optimal PI controller whose parameters are optimized by using dragonfly optimization (DA). The performance of the proposed method is compared with the conventional DA tuned PI and 2‐DOF‐PI control technique to prove the efficacy of the designed technique. The proposed control technique gives better results quantified by performance metrics in nominal case as well as in the presence of parametric uncertainties and noise. The resultant novel controller is verified on a diverse category of patient's responses (ideal, insensitive, and sensitive) to the effect of sodium nitroprusside (SNP) drug injected into the patient's body and thus investigating whether the pressure is at the preferred level.

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“…These methodologies, born mainly for the aerospace and power electronics sector, are also extending to other electronic devices, especially for critical applications. Think for example of medical therapy devices that must interact with a person or part of a person [6][7][8]. During the development and validation phase of medical devices, the patient cannot be involved in the design process for several reasons including the fact that the pathology to be resolved must be induced in the patient just when the device is being tested, which is not easy to implement.…”

Section: Introductionmentioning

confidence: 99%

Hardware in the Loop Implementation of the Oscillator-based Heart Model: A Framework for Testing Medical Devices

Mascio

Gruosso

2020

Electronics

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The hardware in the loop technologies allow to simulate physical models in combination with real devices in order to validate the behavior of the latter under different conditions, not easily reproducible in the real world. They are widely used in various industrial applications. In this work we want to extend the methodology to medical devices. These must interact with the patient to obtain the desired clinical result, however, during the development and validation phase of medical devices, the patient cannot be involved in the testing process. In this article the hardware in the loop methodology is proposed starting from a mathematical model of the heart, based on oscillators, that can be used to validate pacemakers or other medical devices.

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Simple adaptive PI controller development and evaluation for mean arterial pressure regulation

Cited by 10 publications

References 16 publications

Real‐time simulation device for mean arterial pressure of hypotensive patient subjected phenylephrine infusion

Real‐time simulation device for mean arterial pressure of hypotensive patient subjected phenylephrine infusion

Automatic drug infusion control based on metaheuristic H₂ optimal theory for regulating the mean arterial blood pressure

Hardware in the Loop Implementation of the Oscillator-based Heart Model: A Framework for Testing Medical Devices

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Simple adaptive PI controller development and evaluation for mean arterial pressure regulation

Cited by 10 publications

References 16 publications

Real‐time simulation device for mean arterial pressure of hypotensive patient subjected phenylephrine infusion

Real‐time simulation device for mean arterial pressure of hypotensive patient subjected phenylephrine infusion

Automatic drug infusion control based on metaheuristic H2 optimal theory for regulating the mean arterial blood pressure

Hardware in the Loop Implementation of the Oscillator-based Heart Model: A Framework for Testing Medical Devices

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Product

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Automatic drug infusion control based on metaheuristic H₂ optimal theory for regulating the mean arterial blood pressure