Similarity of Interstitial Cystitis (Hunner Ulcer) to Lupus Erythematosus

Fister, George M.

doi:10.1016/s0022-5347(17)71740-5

Cited by 56 publications

(8 citation statements)

References 24 publications

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“…Attention has been paid earlier in the literature to the similarity between IC and connective tissue diseases, especially lupus erythematosus (Dees, 1953;Fister, 1938;Gil-Vemet et al 1960; Shipton, 1965). Many of the clinical and immunological findings for our own patients point to the same direction.…”

Section: Scand J Urol Nephrol4mentioning

confidence: 60%

“…Several hypotheses have been advanced concerning the aetiology of interstitial cystitis, all on uncertain foundations. Focal infection (Hunner), circulatory disturbance combined with infection (Herbst, Baumrucker & German, 1937), lymphatic obstruction (Powell, 1945), hormonal factors (Powell, 1955), psychosomatic or neurogenic causation (Doge, 1959;Gil-Vernet, Gonzalez, Fernandez & Perez-Trujillo, 1960;Weber, 1961), connective tissue disease (Fister, 1938;Dees, 1953; Gil-Vernet et al; Shipton, 1965) and allergy (Hand, 1949) have been suggested.…”

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confidence: 99%

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Interstitial Cystitis: Clinical and Immunological Findings

Oravisto

Alfthan

Jokinen

1970

Scandinavian Journal of Urology and Nephrology

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Fifty-four female patients were treated for interstitial cystitis. The age range was 16 to 80 and the mean age 59 years. The average duration of symptoms before diagnosis was six years.Antinuclear antibodies were demonstrated in 85 per cent of the patients. Allergy of reagin type was present in 13 per cent and hypersensitivity reactions to drugs had occurred in 35 per cent. The series included a pair of monozygotic twins. These observations suggest that interstitial cystitis closely resembles connective tissue disease. The diagnosis must be based on the history in the case together with urinalysis, cystoscopy, biopsy and the response to treatment. The demonstration of antinuclear antibodies is an important diagnostic aid. The biopsy specimens in this series showed that interstitial cystitis always involves the whole of the bladder, though the macroscopic changes often are local.The patients were classified in three groups according to the severity of the symptoms, the capacity of the bladder and the response to treatment. Dilatation of the bladder sufficed in the mild cases and was combined with intramural injections of prednisolone in the moderately severe cases. Subtotal cystectomy and colocystoplasty seemed to give the best results in severe cases. Neurosurgical procedures also seemed to be helpful.As a result of the apparent similarity between interstitial cystitis and connective tissue disease, therapeutic trials with antimalarial agents and salicylates have been begun. MATERIAL, METHODS AND RESULTSThe series consisted of 54 women; 36 were treated at this Urology Unit between 1963 and Scand J Urol Nephrol4 Scand J Urol Nephrol Downloaded from informahealthcare.com by Cornell University on 12/27/14 For personal use only. Scand J Urol Nephrol Downloaded from informahealthcare.com by Cornell University on 12/27/14 For personal use only. Scand J Urol Nephrol Downloaded from informahealthcare.com by Cornell University on 12/27/14 For personal use only. J Urol 67, 903-915. . Cibert, J., Garbit, J. L. & Massoumi, R. 1968. L'ileOcystoplastie dans le traitement de la cystite chronique d'ttiologie non tuberculeuse, non neoplastique, non bilharzienne, de la cystalgie et de la pollakiurie sans cystite. Rtflexions sur les pollakiuries rebelles A l'agrandissement intestinal dans les cystites chroniques. J Urol Nephrol (Paris) 74, 159-171. Darget, R. & Ballanger, R. 1954. Cystires invdtCries el algies pelviennes. Masson & Cie, Paris. Scand J Urol Nephrol4 Scand J Urol Nephrol Downloaded from informahealthcare.com by Cornell University on 12/27/14 For personal use only. 72, 332-341. 377-383.Scand J Urol Nephrol Downloaded from informahealthcare.com by Cornell University on 12/27/14For personal use only.

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Section: Scand J Urol Nephrol4mentioning

confidence: 60%

mentioning

confidence: 99%

Interstitial Cystitis: Clinical and Immunological Findings

Oravisto

Alfthan

Jokinen

1970

Scandinavian Journal of Urology and Nephrology

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“…It is characterised microscopically by an infiltration of lymphocytes, plasma and mast cells and it is known that an accumulation of these immunologically competent cells is observed at some stage in all autoimmune diseases (Mackay and Burnet, 1963). Fister (1938) described the similarity of the microscopic appearance, age and sex distribution of patients with Hunner 's ulcers and lupus erythematosus. Silk (1970) described an association between interstitial cystitis, thyroiditis and rheumatoid arthritis.…”

Section: Discussionmentioning

confidence: 99%

Interstitial Cystitis

ROSIN¹,

GRIFFITHS²,

SOFRAS³

et al. 1979

British Journal of Urology

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Twenty histologically proven cases of interstitial cystitis were investigated in an attempt to find evidence of a possible autoimmune mechanism in its aetiology. HLA tissue typing was performed, autoantibody profiles were obtained, and a questionnaire of the patients' past history completed, especially with respect to other autoimmune conditions. An experiment was designed to test the effect of sodium cromoglycate on rat bladders. The results are discussed in relation to the management of patients with interstitial cystitis.

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“…The interest in autoimmunity as a possible cause of IC dates back to 1938, when Fister [50] noted similarities between IC and systemic lupus erythematosus. Indeed, IC has many of the features of an autoimmune disease: symptom chronicity with exacerbations and remissions; frequent organ-specific mononuclear cell infiltrates; the lack of a clearly defined pathogen; occasional clinical response to steroids or other immunosuppressants [51]; the high prevalence of antinuclear antibodies; and associations with well-described autoimmune syndromes.…”

Section: Autoimmunitymentioning

confidence: 99%

Similarities between interstitial cystitis and male chronic pelvic pain syndrome

Moldwin

2002

Curr Urol Rep

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Few clinical conditions encountered by the urologist cause more patient and clinician frustration than interstitial cystitis and male chronic pelvic pain syndrome, also know as nonbacterial prostatitis. This frustration is fueled by the chronicity of often disabling urogenital (and often associated systemic) symptoms coupled with delayed care, misdiagnosis, and suboptimal clinical responses. Basic research and therapeutic trials for these syndromes have historically taken two separate paths. However, mounting evidence suggests that significant overlap may exist between them in epidemiology, pathophysiology, and even therapy. This discussion reviews some of the common features of these clinical problems and makes a case that they might in fact represent different manifestations of the same disease process.

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Similarity of Interstitial Cystitis (Hunner Ulcer) to Lupus Erythematosus

Cited by 56 publications

References 24 publications

Interstitial Cystitis: Clinical and Immunological Findings

Interstitial Cystitis: Clinical and Immunological Findings

Interstitial Cystitis

Similarities between interstitial cystitis and male chronic pelvic pain syndrome

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