Similarity between non‐neural granular cell tumors and granular cell fibrous papules

Goto, Keisuke

doi:10.1111/cup.12974

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…HMB45 immunostaining is consistently positive in granular cells of melanocytic nevi with granular cell change, pointing to increased melanosome activity 21 . Its resemblance to granular cell fibrous papules 22 has been reported, challenging the diagnosis if the tumor arises on the face of the patient.…”

Section: Discussionmentioning

confidence: 99%

Three additional cases of non‐neural granular cell tumor with novel immunohistochemical findings

et al. 2020

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Background: Non-neural granular cell tumor (NNGCT) is an uncommon neoplasm of controversial histogenesis and its histopathologic differential diagnosis includes, in addition to conventional GCT, other dermal tumors that may exhibit granular cell change. Methods: Three patients with a diagnosis of NNGCT were identified in the authors' files. Hematoxylin and eosin-stained sections and immunohistochemical studies were performed. Results: Histopathological study of the three lesions showed dermal proliferation of granular cells arranged in thick fascicles between collagen bundles. The lesions showed positivity for Factor XIIIa, CD163, CD68, NKIC3, vimentin, ALK, fascin, and cyclin D1. Conclusion: To our knowledge, positivity for cyclin D1 has not been reported to date in NNGCT. In borderline cases, where the diagnosis is unclear despite histopathologic and immunohistochemical findings, positivity for cyclin D1 may favor the diagnosis of NNGCT. Further investigations to assess the differentiation of this rare neoplasm are needed.

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Section: Discussionmentioning

confidence: 99%

Three additional cases of non‐neural granular cell tumor with novel immunohistochemical findings

et al. 2020

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“…Granular cell FP is a rare histopathological subtype, which may mimic non‐neural dermal granular cell tumor, granular cell tumor of unknown differentiation, granular cell basal cell carcinoma, and granular cell dermatomyofibroma 12,13 . Although the dendritic cellular pattern was not evident in hematoxylin & eosin sections due to conspicuous cytoplasmic granular cell change (related to degenerative lysosomal accumulation), strong CD163 immunostaining alluded to the proliferation of dermal dendrocytes.…”

Section: Discussionmentioning

confidence: 99%

Histopathological characteristics and CD163 immunostaining pattern in fibrous papule of the face

et al. 2020

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Background Signs of inflammation including epidermal interface changes, spongiosis, and dermal inflammation as well as pagetoid dyskeratosis are rarely described in fibrous papule (FP). We aimed to describe the inflammatory parameters, the rate of pagetoid dyskeratosis, along with CD163 immunohistochemical staining as an adjunctive diagnostic tool in FP. Methods Histopathology samples of all biopsy‐proven FP cases were retrieved from archives and investigated for inflammatory parameters, presence of pagetoid dyskeratosis, as well as CD163, CD10, and CD34 immunostaining pattern of dermal spindle/stellate or multinucleate cells (graded from 0 to 4). Results Thirty‐two cases of FP were identified. A high rate of inflammatory parameters including interface changes (20/32), spongiosis (31/32), and dermal lymphocytic inflammation (31/32) were detected. Pagetoid dyskeratosis was identified in eight out of 32 cases (25%). A grade 4 staining revealing a strong dendritic pattern was confirmed in all FP cases with CD163 immunohistochemistry including atypical variants such as granular FP, compared with CD10 (11/32) and CD34 (3/32). Conclusion The dendritic cellular proliferation in FP may represent an inflammatory response to various stimuli; pagetoid dyskeratosis is a relatively common and underrecognized epidermal feature and CD163 immunostaining may be used as an adjunctive diagnostic tool in unusual histopathological subtypes.

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Similarity between non‐neural granular cell tumors and granular cell fibrous papules

Cited by 2 publications

References 10 publications

Three additional cases of non‐neural granular cell tumor with novel immunohistochemical findings

Three additional cases of non‐neural granular cell tumor with novel immunohistochemical findings

Histopathological characteristics and CD163 immunostaining pattern in fibrous papule of the face

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