Similarities in solar ultraviolet irradiance and other environmental factors may explain much of the family link between uveal melanoma and other cancers

Abstract

Similarities in solar ultraviolet irradiance and other environmental factors may explain much of the family link between uveal melanoma and other cancers

Hereditary predisposition rather than environmental factor are likely to explain the familial link between uveal melanoma and other cancers

“…We agree with Grant et al [1] that environmental factors are important in increasing cancer risk especially for certain cancers. In order to reduce the bias due to shared environmental factors, we excluded cancers with a strong environmental predisposition such as non-melanoma skin cancer, lung cancer and cancer of the cervix from our assessment [2].…”

“…Grant et al [1] commented on our recent manuscript on family cancer histories of unselected cohort of UM patients [2] and suggested that the familial predisposition observed in our study is likely due to shared environmental factors due to solar UVB dose and possibly Vitamin D status [1]. The authors cites ecological and observational studies suggesting such associations [3].…”

Diabetic Retinopathy and Ocular Melanoma: How Far We Are?

“…Since melanoma results from abnormalities in melanocytes, the most harmful factor affecting these cells is UV exposure, for skin and also for ocular melanomas [178]. In uveal melanoma, UVB radiation is related to the high risk of tumour development [179]. Figure 2 illustrates the mechanism of oxidative stress and its effect in angiogenesis.…”