Similarities in serum oxidative stress markers and inflammatory cytokines in patients with overt schizophrenia at early and late stages of chronicity

Pedrini, Mariana; Massuda, Raffael; Fries, Gabriel R.; Pasquali, Matheus Augusto de Bittencourt; Schnorr, Carlos Eduardo; Moreira, José Cláudio Fonseca; Teixeira, Antônio Lúcio; Lobato, Maria Inês Rodrigues; Walz, Julio Cesar; Belmonte-de-Abreu, Paulo; Kauer-Sant’Anna, Márcia; Kapczinski, Flávio; Gama, Clarissa Severino

doi:10.1016/j.jpsychires.2012.03.019

Cited by 131 publications

(82 citation statements)

References 45 publications

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“…1 Lipid peroxidation and decreased total antioxidant defenses in the blood of schizophrenia patients are persistent findings, [2][3][4][5] providing further evidence for a systemic component of the disease. In the central nervous system, decreased antioxidant defenses have been reported, [6][7][8] as well as markers of oxidative stress in postmortem prefrontal cortex.…”

Section: Introductionmentioning

confidence: 99%

Impaired Metabolic Reactivity to Oxidative Stress in Early Psychosis Patients

Fournier¹,

Ferrari

Baumann

et al. 2014

Schizophrenia Bulletin

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Because increasing evidence point to the convergence of environmental and genetic risk factors to drive redox dysregulation in schizophrenia, we aim to clarify whether the metabolic anomalies associated with early psychosis reflect an adaptation to oxidative stress. Metabolomic profiling was performed to characterize the response to oxidative stress in fibroblasts from control individuals (n = 20) and early psychosis patients (n = 30), and in all, 282 metabolites were identified. In addition to the expected redox/ antioxidant response, oxidative stress induced a decrease of lysolipid levels in fibroblasts from healthy controls that were largely muted in fibroblasts from patients. Most notably, fibroblasts from patients showed disrupted extracellular matrix-and arginine-related metabolism after oxidative stress, indicating impairments beyond the redox system. Plasma membrane and extracellular matrix, 2 regulators of neuronal activity and plasticity, appeared as particularly susceptible to oxidative stress and thus provide novel mechanistic insights for pathophysiological understanding of early stages of psychosis. Statistically, antipsychotic medication at the time of biopsy was not accounting for these anomalies in the metabolism of patients' fibroblasts, indicating that they might be intrinsic to the disease. Although these results are preliminary and should be confirmed in a larger group of patients, they nevertheless indicate that the metabolic signature of reactivity to oxidative stress may provide reliable early markers of psychosis. Developing protective measures aimed at normalizing the disrupted pathways should prevent the pathological consequences of environmental stressors.

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Section: Introductionmentioning

confidence: 99%

Impaired Metabolic Reactivity to Oxidative Stress in Early Psychosis Patients

Fournier¹,

Ferrari

Baumann

et al. 2014

Schizophrenia Bulletin

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show abstract

“…A consistent finding is a decrease of IL2 and IFg, demonstrating a diminished T h 1 response. Also found is a reduced response after stimulation with antigens (Müller 2010a) and evidence for an increase in TNFα (Pedrini 2012 known to produce positive symptoms of psychosis. Atypical antipsychotics have been shown to decrease serum levels of cytokines such as IL6 and TNFα, and therefore it is suggested that some of their effectiveness may be mediated through an antiinflammatory action on microglial activation (Miyaoka 2007).…”

Section: Imbalance In the T Helper Systemmentioning

confidence: 96%

The immune system and schizophrenia: an update for clinicians

Upthegrove¹,

Barnes²

2014

Adv. psychiatr. treat

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“…Nestes pacientes, citocinas pró-inflamatórias (ex. : interleucina-6 [IL-6], IL-1B e fator de necrose tumoral [TNF-α]) foram encontradas elevadas, enquanto a interleucina-10 (IL-10), uma citocina anti-inflamatória, apresentou-se reduzida (154,155). A elevação destas citocinas pró-inflamatórias podem indicar a via do sistema imunológico com que a flora intestinal afeta a função encefálica.…”

Section: Como a Flora Intestinal Pode Afetar O Sncunclassified

Envolvimento Da Flora Intestinal Na Modulação De Doenças Psiquiátricas

Lach

Morais

Costa

et al. 2017

VITTALLE, ISSN 1413-3563, Rio Grande, Brasil

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Nas últimas décadas, o envolvimento da flora intestinal na regulação de processos mediados pelo sistema nervoso central (SNC) tem despertado grande interesse de neurocientistas (um campo de pesquisa até então exclusivo dos microbiologistas). Nesse interim, estudos vêm revelando como a composição da flora intestinal pode participar da fisiologia normal do indivíduo, assim como a associação entre alterações da composição e diversidade da flora e o desenvolvimento de diversas doenças psiquiátricas. Esta comunicação encéfalo-intestinal tende a ocorrer utilizando diferentes vias, como a comunicação por meio endócrino, imunológico e/ou neuronal. Esta troca de informações é diretamente influenciada pela composição da flora intestinal. Estudos pré-clínicos em animais, onde a flora intestinal é alterada, sugerem que as bactérias intestinais regulam vários genes e neurotransmissores envolvidos na modulação de doenças psiquiátricas, como a ansiedade, depressão e o autismo. Desta forma, o conceito de eixo encéfalo-intestinal sugere que a modulação da flora intestinal pode ser uma importante estratégia para o desenvolvimento de novas formas de prevenção e tratamento de doenças do SNC.

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Similarities in serum oxidative stress markers and inflammatory cytokines in patients with overt schizophrenia at early and late stages of chronicity

Cited by 131 publications

References 45 publications

Impaired Metabolic Reactivity to Oxidative Stress in Early Psychosis Patients

Impaired Metabolic Reactivity to Oxidative Stress in Early Psychosis Patients

The immune system and schizophrenia: an update for clinicians

Envolvimento Da Flora Intestinal Na Modulação De Doenças Psiquiátricas

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