Similarities in Coronary Function and Myocardial Deformation Between Psoriasis and Coronary Artery Disease: The Role of Oxidative Stress and Inflammation

Ikonomidis, Ignatios; Makavos, George; Papadavid, Evangelia; Varoudi, Maria; Andreadou, Ioanna; Gravanis, Kostas; Theodoropoulos, Kostas; Pavlidis, George; Triantafyllidi, Helen; Parissis, John; Paraskevaidis, Ioannis; Rigopoulos, Dimitrios; Lekakis, John

doi:10.1016/j.cjca.2014.11.002

Cited by 60 publications

(45 citation statements)

References 42 publications

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“…The reason for this subdivision was the underlying concept of inflammation as a potential impairing factor for myocardial contractility in these patients. Cardiac impairment has been demonstrated before in other autoimmune inflammatory diseases such as psoriasis 38, 39 , rheumatoid arthritis 40 or systemic lupus erythematodes 41 .…”

Section: Discussionmentioning

confidence: 84%

Speckle Tracking Stress Echocardiography Uncovers Early Subclinical Cardiac Involvement in Pediatric Patients with Inflammatory Bowel Diseases

Hensel

Schneyder

Wilke

et al. 2017

Sci Rep

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Inflammatory bowel disease (IBD) is an established risk factor for cardiovascular disease (CVD). However, whether cardiac consequences present early in IBD is unknown. This is the first study in children aiming to unmask altered myocardial mechanics in IBD. We enrolled 50 consecutive normotensive children with Crohn’s disease (CD) (n = 28) or ulcerative colitis (UC) (n = 22). The study groups consisted of 18 patients with active inflammatory disease (mean age 14.6 ± 2.5 years) and 32 children with IBD in remission (14.3 ± 2.3 years). 60 age- and gender-matched children served as healthy controls. Speckle tracking stress echocardiography (STE) was used to assess left ventricular (LV) myocardial strain and strain rate. Circumferential strain rate was significantly decreased in children with active IBD (−1.55 ± 0.26 s−1) and IBD in remission (−1.49 ± 0.26 s−1) versus healthy controls (1.8 ± 0.4 s−1) both at rest (p < 0.001) and during exercise (p = 0.021). Moreover, longitudinal strain rate, circumferential strain and E/E′ ratio were significantly impaired in IBD. Pediatric patients with IBD feature subclinical signs of LV systolic and diastolic myocardial impairment early in the course of CD and UC. This may not be reversible even when IBD is clinically controlled. Patients with IBD should be regularly screened for signs of CVD.

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Section: Discussionmentioning

confidence: 84%

Speckle Tracking Stress Echocardiography Uncovers Early Subclinical Cardiac Involvement in Pediatric Patients with Inflammatory Bowel Diseases

Hensel

Schneyder

Wilke

et al. 2017

Sci Rep

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“…In addition, the psoriatic patients with the dominant AT1R‐A 1166 C polymorphism had significantly higher serum levels of VAP‐1 and MDA but lower total bilirubine, uric acid, ARE, SOD and CAT activities compared to the corresponding control group. This finding indicates that the C allele of the AT1R‐A 1166 C may be considered as a strong independent predictive factor for incidence of oxidative stress and inflammation . These data also suggest that psoriasis patients carrying C allele of AT1R 1166 may be more susceptible to cardiovascular disease and myocardial infarction compared with psoriasis patients carrying A allele of AT1R 1166 .…”

Section: Odd Ratio and Distribution Of Angiotensin II Type 1 Receptormentioning

confidence: 76%

Angiotensin II type 1 receptor A₁₁₆₆C (rs5186) gene polymorphism increased risk and severity of psoriasis, contribution to oxidative stress, antioxidant statues, lipid peroxidation and correlation with vascular adhesion protein 1, preliminary report

Mohammadi

Vaisi‐Raygani

Shakiba

et al. 2015

Acad Dermatol Venereol

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“…This result is harmful to proteins, lipids, and DNA. Oxidative stress can also be assessed by the level of MDA in plasma [35]. Healthy skin maintains a dynamic balance between oxidation and antioxidation, and if this balance is destroyed, some diseases manifest, including psoriasis [36].…”

Section: Discussionmentioning

confidence: 99%

Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice

Zhang

Liu

Mei

et al. 2016

BMC Complement Altern Med

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BackgroundPsoriasis is a chronic inflammatory immune disease with undefined pathogenesis. It is associated with T cells, and the IL-23/IL17 axis is believed to be crucial in the pathogenesis. The present treatments have side effects that influence the compliance of patients. Tea polyphenol is extracted from tea polyphenols, and its main active ingredient is Epigallocatechin-3-gallate (EGCG), which has been shown to have antioxidant, anti-tumor, and anti-ultraviolet radiation effects. Here, we aim to report that EGCG can inhibit imiquimod (IMQ)-induced psoriasis-like inflammation.MethodsWe used BALB/c mice, which were topically treated with IMQ for 6 consecutive days, as a psoriasis mouse model. Topical application of EGCG and treatment with EGCG were conducted in the experiments. Then observed the effects of the two methods on psoriasis-like mice dermatitis. Statistics are presented as the means ± standard error of mean (SEM) and compared using unpaired two-tailed Student’s t tests or one-way ANOVA.ResultsTopical application of EGCG alleviated psoriasiform dermatitis, improved the skin pathological structure by reduce the expression of epidermal PCNA, promoted the expression of caspase-14. Treatment with EGCG attenuated skin inflammation, accompanied by reduced infiltrations of T cells; reduced percentages of CD11c+ DC in the composition of immunocytes of spleens; reduced levels of interleukin (IL)-17A, IL-17F, IL-22, IL-23 and malondialdehyde (MDA) in plasma; increased percentages of CD4+ T cells in the composition of immunocytes of spleens; and increased bioactivities of superoxide dismutase (SOD) and catalase (CAT) in plasma.ConclusionsAll the results demonstrated that EGCG had anti-inflammatory, immune regulatory and antioxidant effects. It is a promising intervention in psoriasis in the future.

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Similarities in Coronary Function and Myocardial Deformation Between Psoriasis and Coronary Artery Disease: The Role of Oxidative Stress and Inflammation

Cited by 60 publications

References 42 publications

Speckle Tracking Stress Echocardiography Uncovers Early Subclinical Cardiac Involvement in Pediatric Patients with Inflammatory Bowel Diseases

Speckle Tracking Stress Echocardiography Uncovers Early Subclinical Cardiac Involvement in Pediatric Patients with Inflammatory Bowel Diseases

Angiotensin II type 1 receptor A₁₁₆₆C (rs5186) gene polymorphism increased risk and severity of psoriasis, contribution to oxidative stress, antioxidant statues, lipid peroxidation and correlation with vascular adhesion protein 1, preliminary report

Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice

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Similarities in Coronary Function and Myocardial Deformation Between Psoriasis and Coronary Artery Disease: The Role of Oxidative Stress and Inflammation

Cited by 60 publications

References 42 publications

Speckle Tracking Stress Echocardiography Uncovers Early Subclinical Cardiac Involvement in Pediatric Patients with Inflammatory Bowel Diseases

Speckle Tracking Stress Echocardiography Uncovers Early Subclinical Cardiac Involvement in Pediatric Patients with Inflammatory Bowel Diseases

Angiotensin II type 1 receptor A1166C (rs5186) gene polymorphism increased risk and severity of psoriasis, contribution to oxidative stress, antioxidant statues, lipid peroxidation and correlation with vascular adhesion protein 1, preliminary report

Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice

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Angiotensin II type 1 receptor A₁₁₆₆C (rs5186) gene polymorphism increased risk and severity of psoriasis, contribution to oxidative stress, antioxidant statues, lipid peroxidation and correlation with vascular adhesion protein 1, preliminary report