Similarities and differences in working memory and neurometabolism of obsessive-compulsive disorder and major depressive disorder

He, Jiali; Yan, Suxia; Song, Zijin; Lu, Qianyi; Zhong, Shuming; Lai, Shunkai; Wang, Ying; Chen, Guanmao; Zhao, Hui; Chen, Pan; Zhang, Yiliang; Jia, Yanbin

doi:10.1016/j.jad.2022.05.069

Cited by 5 publications

(4 citation statements)

References 62 publications

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“…Poor executive functioning is also found in 40–60% of DCD cases ( 3 , 27 ), including the three main areas of working memory (especially visuospatial working memory), inhibitory control and cognitive flexibility ( 27 ). Working memory can be assessed using the digit span test ( 28 , 29 ), and visuospatial working memory can be assessed using the Groton Maze Learning Test (GMLT) and the block tapping test ( 30 ). Multiple test tasks such as the Go/NoGo test ( 31 ), Stroop test ( 32 , 33 ), Tower of London test ( 31 ), etc.…”

Section: Assessment Of Children With Dcdmentioning

confidence: 99%

Children with developmental coordination disorders: a review of approaches to assessment and intervention

Gao,

Song,

Zhong

et al. 2024

Front. Neurol.

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Developmental Coordination Disorder (DCD) is a neurodevelopmental disorder characterized by deficits in motor skills, with gross and fine motor dysfunction being the main symptom. This condition greatly impairs children’s daily life, learning, and social interaction. Symptoms typically appear during preschool or school age, and if left untreated, they can persist into adulthood. Thus, early assessment and intervention are crucial to improve the prognosis. This study aims to review the existing literature on DCD, providing a comprehensive overview of the assessment for children with DCD in terms of body functions and structures, activities and participation, and environmental factors within the framework of the International Classification of Functioning, Disability, and Health - Children and Youth (ICF-CY). Additionally, specific rehabilitation interventions will be described, offering valuable insights for the clinical assessment and intervention of children with DCD.

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Section: Assessment Of Children With Dcdmentioning

confidence: 99%

Children with developmental coordination disorders: a review of approaches to assessment and intervention

Gao,

Song,

Zhong

et al. 2024

Front. Neurol.

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“…One of us took up this idea in a review on psychogenic and organic causes of retrograde amnesia by entitling it “two sides of the same coin” (Markowitsch, 1996). In fact, brain correlates for memory impairments in psychiatric diseases have been found numerously in the last decades (e.g., T. J. Barry, Clark, & Maguire, 2021; Guimond et al, 2022; He et al, 2022; Liu et al, 2021; Wie et al, 2022).…”

Section: Brain Bases Of the Memory Systemsmentioning

confidence: 99%

“…In fact, brain correlates for memory impairments in psychiatric diseases have been found numerously in the last decades (e.g., T. J. Barry, Clark, & Maguire, 2021;Guimond et al, 2022;He et al, 2022;Liu et al, 2021;Wie et al, 2022).…”

Section: Specific Impairments Of Autobiographical Memory Retrievalmentioning

confidence: 99%

Behavioral, neurological, and psychiatric frailty of autobiographical memory

Markowitsch

Staniloiu

2022

WIRES Cognitive Science

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Autobiographical‐episodic memory is considered to be the most complex of the five long‐term memory systems. It is autonoetic, which means, self‐reflective, relies on emotional colorization, and needs the features of place and time; it allows mental time traveling. Compared to the other four long‐term memory systems—procedural memory, priming, perceptual, and semantic memory—it develops the latest in phylogeny and ontogeny, and is the most vulnerable of the five systems, being easily impaired by brain damage and psychiatric disorders. Furthermore, it is characterized by its fragility and proneness to distortion due to environmental influences and subsequent information. On the brain level, a distinction has to be made between memory encoding and consolidating, memory storage, and memory retrieval. For encoding, structures of the limbic system, with the hippocampus in its center, are crucial, for storage of widespread cortical networks, and for retrieval again a distributed recollection network, in which the prefrontal cortex plays a crucial role, is engaged. Brain damage and psychiatric diseases can lead to what is called “focal retrograde amnesia.” In this context, the clinical picture of dissociative or functional or psychogenic amnesia is central, as it may result in autobiographical‐emotional amnesia of the total past with the consequence of an impairment of the self as well. The social environment therefore can have a major impact on the brain and on autobiographical‐episodic memory processing. This article is categorized under: Psychology > Memory

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“…Although low Glu and tNAA have been significantly linked to specific MDD symptom domains including mood and cognition [ 55 – 60 ], studies have primarily examined the relationship between baseline metabolite levels and overall depression symptom scores following rTMS [ 41 ]. This is a limitation of the current literature, as rTMS has demonstrated the ability to ameliorate a broad spectrum of symptoms [ 61 – 64 ].…”

Section: Introductionmentioning

confidence: 99%

Cortical glutamate, Glx, and total N-acetylaspartate: potential biomarkers of repetitive transcranial magnetic stimulation treatment response and outcomes in major depression

Gonsalves,

White,

Barredo

et al. 2024

Transl Psychiatry

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Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for individuals with major depressive disorder (MDD) who have not improved with standard therapies. However, only 30–45% of patients respond to rTMS. Predicting response to rTMS will benefit both patients and providers in terms of prescribing and targeting treatment for maximum efficacy and directing resources, as individuals with lower likelihood of response could be redirected to more suitable treatment alternatives. In this exploratory study, our goal was to use proton magnetic resonance spectroscopy to examine how glutamate (Glu), Glx, and total N-acetylaspartate (tNAA) predict post-rTMS changes in overall MDD severity and symptoms, and treatment response. Metabolites were measured in a right dorsal anterior cingulate cortex voxel prior to a standard course of 10 Hz rTMS to the left DLPFC in 25 individuals with MDD. MDD severity and symptoms were evaluated via the Inventory of Depression Symptomatology Self-Report (IDS-SR). rTMS response was defined as ≥50% change in full-scale IDS-SR scores post treatment. Percent change in IDS-SR symptom domains were evaluated using principal component analysis and established subscales. Generalized linear and logistic regression models were used to evaluate the relationship between baseline Glu, Glx, and tNAA and outcomes while controlling for age and sex. Participants with baseline Glu and Glx levels in the lower range had greater percent change in full scale IDS-SR scores post-treatment (p < 0.001), as did tNAA (p = 0.007). Low glutamatergic metabolite levels also predicted greater percent change in mood/cognition symptoms (p ≤ 0.001). Low-range Glu, Glx, and tNAA were associated with greater improvement on the immuno-metabolic subscale (p ≤ 0.003). Baseline Glu predicted rTMS responder status (p = 0.025) and had an area under the receiving operating characteristic curve of 0.81 (p = 0.009), demonstrating excellent discriminative ability. Baseline Glu, Glx, and tNAA significantly predicted MDD improvement after rTMS; preliminary evidence also demonstrates metabolite association with symptom subdomain improvement post-rTMS. This work provides feasibility for a personalized medicine approach to rTMS treatment selection, with individuals with Glu levels in the lower range potentially being the best candidates.

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Similarities and differences in working memory and neurometabolism of obsessive-compulsive disorder and major depressive disorder

Cited by 5 publications

References 62 publications

Children with developmental coordination disorders: a review of approaches to assessment and intervention

Children with developmental coordination disorders: a review of approaches to assessment and intervention

Behavioral, neurological, and psychiatric frailty of autobiographical memory

Cortical glutamate, Glx, and total N-acetylaspartate: potential biomarkers of repetitive transcranial magnetic stimulation treatment response and outcomes in major depression

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