2008
DOI: 10.1007/s00210-008-0316-5
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Similarities and differences in the autonomic control of airway and urinary bladder smooth muscle

Abstract: The airways and the urinary bladder are both hollow organs serving very different functions, i.e. air flow and urine storage, respectively. While the autonomic nervous system seems to play only a minor if any role in the physiological regulation of airway tone during normal breathing, it is important in the physiological regulation of bladder smooth muscle contraction and relaxation. While both tissues share a greater expression of M 2 than of M 3 muscarinic receptors, smooth muscle contraction in both is larg… Show more

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Cited by 18 publications
(8 citation statements)
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“…This “resistance” of carbachol-induced tone against relaxation did not apply to the receptor-independent relaxation by forskolin. As the autonomic regulation of smooth muscle tone in the bladder and airways has many similarities [ 17 ], it is interesting to note that studies on human airways has also reported that β-adrenoceptor agonists cause weaker relaxation against contraction induced by carbachol than against other stimuli [ 18 , 19 ], thus indirectly supporting our findings. One possible mechanistic explanation of these findings is a specific interaction between M 2 muscarinic and β-adrenergic receptors as has been proposed in rats [ 20 ] and mice [ 21 ].…”
Section: Discussionsupporting
confidence: 87%
“…This “resistance” of carbachol-induced tone against relaxation did not apply to the receptor-independent relaxation by forskolin. As the autonomic regulation of smooth muscle tone in the bladder and airways has many similarities [ 17 ], it is interesting to note that studies on human airways has also reported that β-adrenoceptor agonists cause weaker relaxation against contraction induced by carbachol than against other stimuli [ 18 , 19 ], thus indirectly supporting our findings. One possible mechanistic explanation of these findings is a specific interaction between M 2 muscarinic and β-adrenergic receptors as has been proposed in rats [ 20 ] and mice [ 21 ].…”
Section: Discussionsupporting
confidence: 87%
“…The EFS was performed at a frequency that elicited similar maximal force and RLC phosphorylation responses. Although trachea and other smooth muscles express M2 and M3 receptors, smooth muscle contraction of the airways occurs largely, if not exclusively, via M3 receptors (Michel & Parra, ). Thus, differences in the chemical effector or muscarinic receptors do not provide a satisfactory explanation.…”
Section: Discussionmentioning
confidence: 99%
“…However, the problem apparently goes well beyond the homology of closely related GPCR subtypes. For example, airways express only the M 2 and M 3 subtype of muscarinic receptors (Michel and Parra 2008) but double-knock-out mice lacking both subtypes still stained positive for M 2 and M 3 receptor antibodies (Jositsch et al 2009). Similarly, triple knock-out mice lacking all three α 1 -adrenoceptor subtypes show similar staining patters as wild-type mice (Jensen et al 2009).…”
Section: Why Do So Many Gpcr Antibodies Lack Selectivity?mentioning
confidence: 99%