Similarities and differences between the interictal epileptiform discharges of green-spikes and red-spikes zones of human neocortex

Serafini, Ruggero

doi:10.1016/j.clinph.2018.12.011

Cited by 13 publications

(21 citation statements)

References 25 publications

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“…Another iEEG phenomenon connected to epileptogenic tissue and the hippocampus are interictal epileptic discharges (IEDs). They have been proven to be insufficiently specific for the pathological tissue (16), they propagate across multiple brain structures or are generated in zones not generating seizures (green spikes) (17) and can even occur in non epileptic hippocampus (6).…”

Section: Introductionmentioning

confidence: 99%

Cognitive Processing Impacts High Frequency Intracranial EEG Activity of Human Hippocampus in Patients With Pharmacoresistant Focal Epilepsy

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Cognitive Processing Impacts High Frequency Intracranial EEG Activity of Human Hippocampus in Patients With Pharmacoresistant Focal Epilepsy

et al. 2020

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“…Acknowledging the occurrence of n-waves can pave the way for further study of their roles and mechanisms. specific to neocortical epileptic discharge zones [11,12]. Therefore, the analysis focused on recordings from subdural neocortical grids.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the analysis focused on recordings from subdural neocortical grids. A previous paper [12] reported details of the neurophysiological methodology. The demographics, anatomy, pathology, and outcomes of clinical cases are reported in Table 1 of that paper [12] and appear in Table 1 of this study.…”

Section: Introductionmentioning

confidence: 99%

“…A previous paper [12] reported details of the neurophysiological methodology. The demographics, anatomy, pathology, and outcomes of clinical cases are reported in Table 1 of that paper [12] and appear in Table 1 of this study. Cases consisted of patients with chronic, drug-resistant epilepsy who underwent intracranial EEGs as part of a workup related to surgical evaluation.…”

Section: Introductionmentioning

confidence: 99%

“…I reviewed intracranial EEGs performed between 2012 and 2016. Inclusion criteria included the presence of IEDs in subdural grids and/or strips, regardless of age, sex, race, ethnicity, seizure frequency, and The patient cases used in this study were taken from prior research [12]. Data in the above table overlap with Table 1 in Serafini [12], differing only in the presence of the last column on the right (in grey), which reports nwaves.…”

Section: Introductionmentioning

confidence: 99%

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Human neocortical interictal epileptiform discharges are initiated by a low-voltage negative polarity wave

Serafini

2020

Seizure

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In between seizures, the brain of a patient with epilepsy will generate isolated, sporadic discharges (interictal epileptiform discharges [IEDs]). IED identification enables clinicians to diagnose epilepsy, and an understanding of IED waveforms may yield new insights into basic epilepsy mechanisms. I show that intracranial EEGs disclose a previously unreported negative polarity, low-voltage pre-potential at IED onset (i.e., a negative wave [n-wave]). I describe the features of n-waves and propose a plausible mechanism of their generation. Method: In intracranial EEGs of the human neocortex, I assessed n-waves' occurrence, anatomical location, amplitude, kinetics, and association with the subsequent positive pre-potential. I computed a model simulation of IED onset to identify plausible mechanisms behind n-wave generation. Results: N-waves manifested in 40% of patients, in zones with and without seizures, and without a statistically significant prevalence in their anatomical location. These waveforms exhibited voltages of 140+42 μV and durations of 39.9+12.2 msec and were coupled with a positive pre-potential. In simulations of IED onset, nwaves can be generated by sequential recruitment of distinct microfoci over superficial cortical laminae. Conclusions: N-waves represent an overlooked component of IED waveforms. They prolong the duration of IED onset and can facilitate synaptic hypersynchrony. They may also be associated with chronic epilepsy. Subjects/materials and methodsI performed a retrospective review of intracranial EEGs obtained at the University of Utah between 2012 and 2016. Data analysis was conducted during a project aimed at identifying the features of IEDs

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Multiscale neuro-inspired models for interpretation of EEG signals in patients with epilepsy

Wendling,

Koksal-Ersoz,

Al-Harrach

et al. 2024

Clinical Neurophysiology

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Similarities and differences between the interictal epileptiform discharges of green-spikes and red-spikes zones of human neocortex

Cited by 13 publications

References 25 publications

Cognitive Processing Impacts High Frequency Intracranial EEG Activity of Human Hippocampus in Patients With Pharmacoresistant Focal Epilepsy

Cognitive Processing Impacts High Frequency Intracranial EEG Activity of Human Hippocampus in Patients With Pharmacoresistant Focal Epilepsy

Human neocortical interictal epileptiform discharges are initiated by a low-voltage negative polarity wave

Multiscale neuro-inspired models for interpretation of EEG signals in patients with epilepsy

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