Similarities and controversies in imaging of pediatric renal tumors: A SIOP‐RTSG and COG collaboration

Beek, Justine N. van der; Artunduaga, Maddy; Schenk, Jens‐Peter; Eklund, Meryle J.; Smith, Ethan A.; Lederman, Henrique Manoel; Warwick, Anne B.; Littooij, Annemieke S.; Khanna, Geetika

doi:10.1002/pbc.30080

Cited by 9 publications

(8 citation statements)

References 122 publications

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“…Further improvements in non‐invasive diagnosis of childhood kidney tumours can be expected by the addition of interpretation of MRI images including radiomics. First results are already available, showing that different MRI modalities (T1, T1 plus contrast enhancement, T2, DWI) as well as radiomic parameters might be beneficial in such a setting 4,6,8,10,26,33,34 . Postprocessing techniques of DWI can be helpful in discriminating WT subtypes 33 .…”

Section: Discussionmentioning

confidence: 99%

“…First results are already available, showing that different MRI modalities (T1, T1 plus contrast enhancement, T2, DWI) as well as radiomic parameters might be beneficial in such a setting. 4,6,8,10,26,33,34 Postprocessing techniques of DWI can be helpful in discriminating WT subtypes. 33 Littooij et al…”

Section: Unilateral Localized Tumoursmentioning

confidence: 99%

“…3 Therefore, exact non-invasive diagnosis is essential and accurate initial imaging studies are required, 3,5 including abdominal ultrasound (US), cross sectional magnetic resonance imaging (MRI) with and without contrast enhancement and computed tomography (CT) of the lungs, to detect atypical features that should prompt biopsy and to determine overall tumour stage. 2,6 MRI plays a key role for the detection of a kidney mass, of venous invasion and synchronous contralateral kidney lesions. 7,8 WT presents as a large mostly solid and heterogeneous tumour of the kidney often with intra-tumoural bleeding and is characterized by a high signal intensity on T2-and intermediate signal intensity on T1-weighted images.…”

Section: Introductionmentioning

confidence: 99%

“…Fine‐needle or tru‐cut biopsies are reserved for patients with unusual clinical presentation or atypical imaging findings 3 . Therefore, exact non‐invasive diagnosis is essential and accurate initial imaging studies are required, 3,5 including abdominal ultrasound (US), cross sectional magnetic resonance imaging (MRI) with and without contrast enhancement and computed tomography (CT) of the lungs, to detect atypical features that should prompt biopsy and to determine overall tumour stage 2,6 . MRI plays a key role for the detection of a kidney mass, of venous invasion and synchronous contralateral kidney lesions 7,8 .…”

Section: Introductionmentioning

confidence: 99%

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How to improve initial diagnostic accuracy of kidney tumours in childhood?—A non‐invasive approach

Welter,

Metternich,

Furtwängler

et al. 2024

Intl Journal of Cancer

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Non‐invasive differentiation of paediatric kidney tumours is particularly important in the SIOP‐RTSG protocols, which recommend pre‐operative chemotherapy without histological confirmation. The identification of clinical and tumour‐related parameters may enhance diagnostic accuracy. Age, metastases, and tumour volume (TV) were retrospectively analysed in 3306 patients enrolled in SIOP/GPOH 9, 93‐01, and 2001 including Wilms tumour (WT), congenital mesoblastic nephroma (CMN), clear cell sarcoma (CCSK), malignant rhabdoid tumour of the kidney (MRTK), and renal cell carcinoma (RCC). WT was diagnosed in 2927 (88.5%) patients followed by CMN 138 (4.2%), CCSK 126 (3.8%), MRTK 58 (1.8%) and RCC 57 (1.7%). CMN, the most common localized tumour (71.6%) in patients younger than 3 months of age, was diagnosed earliest and RCC the latest (median age [months]: 0 and 154, respectively) both associated with significantly smaller TV (median TV [mL]: 67.2 and 45.0, respectively). RCC occurred in >14% of patients older than 120 months or older than 84 months with TV <100 mL. Receiver operating characteristic analyses discriminated WT from CMN, RCC and MRTK regarding age (AUC = 0.976, 0.929 and 0.791) and TV (AUC = 0.768, 0.813 and 0.622). MRTK had the highest risk of metastasis (37.9%) despite young age, whereas the risk of metastasis increased significantly with age in WT. Age and TV at diagnosis can differentiate WT from CMN and RCC. MRTK must be considered for metastatic tumours at young age. Identification of CCSK without histology remains challenging. Combined with MRI‐characteristics, including diffusion‐weighted imaging, and radiomics and liquid biopsies in the future, our approach allows optimization of biopsy recommendations and prevention of misdiagnosis‐based neoadjuvant treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Unilateral Localized Tumoursmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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How to improve initial diagnostic accuracy of kidney tumours in childhood?—A non‐invasive approach

Welter,

Metternich,

Furtwängler

et al. 2024

Intl Journal of Cancer

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“…In practically all tumors, the ultimate diagnosis and classification of clinically important subtypes still depend on histopathologic diagnosis [5]. Imaging is critical in the diagnosis, staging, and follow-up of these tumors [6].…”

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confidence: 99%

Clinicopathological assessment of renal tumors in pediatric age group in a sample of Iraqi patients

Ahmad,

Ban J. Qasim,

Alaa G. Hussein

2023

Iraqi j. cancer med. genet.

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Background: According to the Iraqi Cancer Registry, renal carcinoma is the 13th most common carcinoma, with 798 registered cases in 2020 and 418 deaths. Methods: This is a cross sectional retrospective study that includes the analysis of 116 randomly selected sample of pediatric patients (74 nephrectomies and 42 biopsies) sent to the Teaching Laboratories of AL-Emamain AL-Kadhmain city (AS), Baghdad medical city, and private laboratories from January 2019 to January 2023. Results: Histopathological diagnosis revealed a ratio from malignant to benign of 7.4:1. Wilm’s tumor was the most common malignant tumor (65.5%), while multicystic renal dysplasia was the most common benign tumor (7.8%). Abdominal pain was the most common clinical feature (67.2%), followed by abdominal mass (20.7%). Regarding malignant cases, Pathological stage I was the most common (39.0%). As for the histopathological subtype, triphasic type was the most common (57.1%), followed by the biphasic type (10.5%). Conclusions, Malignant tumors make up the vast majority of renal tumors. Wilm tumor is the predominant malignant tumor. Fortunately, most cases of Wilm tumors exhibited an early stage and favorable histology. Neuroblastoma was the second most common malignant tumor. The abdominal lump is the most common presentation of pediatric renal tumor.

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Nierentumoren bei Kindern und Jugendlichen

Tsiflikas

2023

Radiologie

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Similarities and controversies in imaging of pediatric renal tumors: A SIOP‐RTSG and COG collaboration

Cited by 9 publications

References 122 publications

How to improve initial diagnostic accuracy of kidney tumours in childhood?—A non‐invasive approach

How to improve initial diagnostic accuracy of kidney tumours in childhood?—A non‐invasive approach

Clinicopathological assessment of renal tumors in pediatric age group in a sample of Iraqi patients

Nierentumoren bei Kindern und Jugendlichen

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