Similar Peritonitis Outcome in Capd and APD Patients with Dialysis Modality Continuation during Peritonitis

Rüger, Wim; Ittersum, Frans J. van; Comazzetto, Luiz; Hoeks, Sanne E.; Wee, Pieter M. ter

doi:10.3747/pdi.2009.00235

Cited by 42 publications

(30 citation statements)

References 30 publications

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“…Information about immunosuppressive treatment in this group of patients would be interesting, but it was not available in the database. In the present cohort, PD modality was not a predictor of any outcomes, which is in agreement with previous reports (1,22). However, transference to CAPD is a common practice in our country due to concerns of adequate antibiotic dosing during APD and the subgroup of APD patients who were transiently transferred to CAPD for peritonitis treatment presented a higher non-resolution rate.…”

Section: Discussionsupporting

confidence: 81%

Novel Predictors of Peritonitis-Related Outcomes in the BRAZPD Cohort

Olandoski

Júnior

Martin

et al. 2014

Peritoneal Dialysis International

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Section: Discussionsupporting

confidence: 81%

Novel Predictors of Peritonitis-Related Outcomes in the BRAZPD Cohort

Olandoski

Júnior

Martin

et al. 2014

Peritoneal Dialysis International

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“…There was no statistical difference found in regard to hospitalization, and all other outcomes, including catheter removal and temporary or permanent transfer to hemodialysis, were comparable between the two modalities. These results can be compared with a single-center study performed by Rüger et al, which found no difference between CAPD and APD patients during treatment of 508 episodes of PD-related peritonitis in 205 patients with respect to the outcomes of relapse, mortality, or the combined end point of mortality plus catheter removal (28). There are a number of possible explanations for our findings.…”

Section: Discussionsupporting

confidence: 62%

The Association between Peritoneal Dialysis Modality and Peritonitis

Lan¹,

Johnson²,

McDonald³

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives There is conflicting evidence comparing peritonitis rates among patients treated with continuous ambulatory peritoneal dialysis (CAPD) or automated peritoneal dialysis (APD). This study aims to clarify the relationship between peritoneal dialysis (PD) modality (APD versus CAPD) and the risk of developing PD-associated peritonitis.Design, setting, participants, & measurements This study examined the association between PD modality (APD versus CAPD) and the risks, microbiology, and clinical outcomes of PD-associated peritonitis in 6959 incident Australian PD patients between October 1, 2003, and December 31, 2011, using data from the Australia and New Zealand Dialysis and Transplant Registry. Median follow-up time was 1.9 years.Results Patients receiving APD were younger (60 versus 64 years) and had fewer comorbidities. There was no association between PD modality and time to first peritonitis episode (adjusted hazard ratio [HR] for APD versus CAPD, 0.98; 95% confidence interval [95% CI], 0.91 to 1.07; P=0.71). However, there was a lower hazard of developing Gram-positive peritonitis with APD than CAPD, which reached borderline significance (HR, 0.90; 95% CI, 0.80 to 1.00; P=0.05). No statistically significant difference was found in the risk of hospitalizations (odds ratio, 1.12; 95% CI, 0.93 to 1.35; P=0.22), but there was a nonsignificant higher likelihood of 30-day mortality (odds ratio, 1.33; 95% CI, 0.93 to 1.88; P=0.11) at the time of the first episode of peritonitis for patients receiving APD. For all peritonitis episodes (including subsequent episodes of peritonitis), APD was associated with lower rates of culture-negative peritonitis (incidence rate ratio [IRR], 0.81; 95% CI, 0.69 to 0.94; P=0.002) and higher rates of gram-negative peritonitis (IRR, 1.28; 95% CI, 1.13 to 1.46; P=0.01).Conclusions PD modality was not associated with a higher likelihood of developing peritonitis. However, APD was associated with a borderline reduction in the likelihood of a first episode of Gram-positive peritonitis compared with CAPD, and with lower rates of culture-negative peritonitis and higher rates of Gram-negative peritonitis. Peritonitis outcomes were comparable between both modalities.

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“…ISPD guidelines from 2012 [10] reported the use of first-generation cephalosporin, or glycopeptides is recommended according to region and patient characteristics. International Pediatric Peritonitis Registry recently reported the outcomes of 548 episodes of PD peritonitis in 392 pediatric patients from 44 pediatric dialysis centers [41, 42]. The study showed widespread variations in terms of practice, microbiology, and outcomes for peritonitis across the world.…”

Section: Discussionmentioning

confidence: 99%

Peritonitis in Children on Chronic Peritoneal Dialysis: The Experience of a Large National Pediatric Cohort

Ponce¹,

Pécoits-Filho²,

Figueiredo³

et al. 2017

Blood Purif

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Background: We performed this study to evaluate the incidence, risk factors, microbiology, treatment, and outcome of peritonitis in pediatric Peritoneal dialysis (PD) patients at a nationwide prospective study. Methodology: Patients younger than 18 years recruited in the BRAZPD II study from 2004 to 2011, who presented their first peritonitis episode, were included in the study. Results: We found 125 first episodes of peritonitis in 491 children PD patients (0.43 episodes/patient-year). Patients free of peritonitis episode constituted 75.6% in 1 year. Culture-negative episodes were very high (59.2%) and gram-positive (GP) bacteria were the most commonly found organisms (58.8%). First-generation cephalosporin was the initial choice to cover GP (40.5%) and aminoglycosides was the most prescribed antibiotics used for gram-negative agents (27.5%). Treatment failure was 26.4%. Technique failure (TF) occurred in 12.1% and peritonitis was the main cause (65.1%). Pseudomonas (p = 0.04) and negative cultures (p < 0.001) were identified as predictors of TF. Conclusion: Peritonitis remains a common complication of PD in children and negative cultures and pseudomonas had a negative impact on TF.

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Similar Peritonitis Outcome in Capd and APD Patients with Dialysis Modality Continuation during Peritonitis

Cited by 42 publications

References 30 publications

Novel Predictors of Peritonitis-Related Outcomes in the BRAZPD Cohort

Novel Predictors of Peritonitis-Related Outcomes in the BRAZPD Cohort

The Association between Peritoneal Dialysis Modality and Peritonitis

Peritonitis in Children on Chronic Peritoneal Dialysis: The Experience of a Large National Pediatric Cohort

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