Similar Morphological and Intracellular Biochemical Changes in Alcoholic Acute Pancreatitis and Ischemic Acute Pancreatitis in Rats

Chronic Alcohol Intake Increases the Severity of Pancreatitis Induced by Acute Alcohol Administration, Hyperlipidemia and Pancreatic Duct Obstruction in Rats

“…Thus, it is speculated that alcoholic pancreatitis develops only if the toxic effects of alcohol are combined with other pathological factors. Many possible cofactors of pancreatitis such as hyperlipidemia [24], temporary pancreatic duct obstruction [25,26], cigarette smoke [6] or genetic factors (e.g. HLA antigens, α 1 -antitrypsin and ADH phenotypes) have been identified [5,27].…”

Stimulation of stellate cells by injured acinar cells: a model of acute pancreatitis induced by alcohol and fat (VLDL)

“…Therefore, additional factors accompanying alcohol intake must be coresponsible for the induction of the disease. Some of these cofactors such as stimulation of pancreatic secretion and/or obstruction of pancreatic outflow have been experimentally observed by us and others (8,12,25,26).…”

“…Therefore, additional factors accompanying alcohol intake must be coresponsible for the induction of the disease. Some of these cofactors such as stimulation of pancreatic secretion and/or obstruction of pancreatic outflow have been experimentally observed by us and others (8,12,25,26).Clinical experience has taught us that a large number of patients presenting an acute event of alcoholic pancreatitis have drunk lots of alcohol together with an opulent (fat enriched) meal the day before onset of the disease. In the present study, we focused on the effects of lipids in combination with alcohol on acinar cell injury and fibrogenesis.…”

Effect of type of alcoholic beverage in causing acute pancreatitis

“…However, in animal models it seems that ethanol alone is not enough to induce acute pancreatitis 27,28 . Beer 29 and wine 30 include polyphenols with antioxidant capabilities.…”