Similar effect on REM sleep but differential effect on slow wave sleep of the two 5-HT uptake inhibitors zimeldine and alaproclate in cats and rats

Sommerfelt, Liv; Hauge, Erik R.; Ursin, Reidun

doi:10.1007/bf01244644

Cited by 26 publications

(3 citation statements)

References 44 publications

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“…Thus, it can be hypothesized that antisense plasmidinduced changes in 5-HT neurotransmission, particularly in the hypothalamus, might affect the activity of the circadian oscillator, thereby altering sleep-wakefulness rhythms. Interestingly, 5-HT uptake blockade by SSRIs has also been reported to increase W and decrease SWS and REMS during the light period (Sommerfelt et al, 1987;Maudhuit et al, 1994).…”

Section: Controlmentioning

confidence: 97%

Homeostatic Regulation of Serotonergic Function by the Serotonin Transporter As Revealed by Nonviral Gene Transfer

et al. 2000

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With the aim of exploring the relationship between the serotonin transporter (5-HTT or SERT) and the activity level of serotonin (5-HT) neurotransmission, in vivo expression of this protein was specifically altered using a nonviral DNA transfer method. Plasmids containing the entire coding sequence or a partial antisense sequence of the 5-HTT gene were complexed with the cationic polymer polyethylenimine and injected into the dorsal raphe nucleus of adult male rats. Significant increase or decrease in both [(3)H]citalopram binding and [(3)H]5-HT synaptosomal uptake were observed in various brain areas up to 2 weeks after a single administration of the sense plasmid or 7 d after injection of the short antisense plasmid, respectively. Such changes in 5-HTT expression were associated with functional alterations in 5-HT neurotransmission, as shown by the increased capacity of 5-HT(1A) receptor stimulation to enhance [(35)S]GTP-gamma-S binding onto the dorsal raphe nucleus in sections from rats injected with the sense plasmid. Conversely, both a decrease in 5-HT(1A)-mediated [(35)S]GTP-gamma-S binding and a reduced potency of the 5-HT(1A) receptor agonist ipsapirone to inhibit neuronal firing were observed in the dorsal raphe nucleus of antisense plasmid-injected rats. Furthermore, changes in brain 5-HT and/or 5-HIAA levels, and sleep wakefulness circadian rhythm in the latter animals demonstrated that altered expression of 5-HTT by recombinant plasmids has important functional consequences on central 5-HT neurotransmission in adult rats.

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Section: Controlmentioning

confidence: 97%

Homeostatic Regulation of Serotonergic Function by the Serotonin Transporter As Revealed by Nonviral Gene Transfer

et al. 2000

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“…1979). Treatment with 5-HT uptake inhibitors increases SWS in rats (Sommerfelt et al 1987). Howevet', a recent study shows simultaneous increase of highly synchronized SWS and waking in rats treated with the uptake inhibitor zimelidine (Ursin et al 1989).…”

Section: Discussionmentioning

confidence: 96%

Effects of indole‐pyruvic acid on sleep and food intake in the rat

Pich¹,

Solfrini²,

Biagini³

et al. 1990

Acta Physiologica Scandinavica

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Indole-pyruvic acid was studied for its short- and long-term effects on electroencephalographic sleep and on food intake in rats implanted with cortical and muscular electrodes. Following a single injection, indole-pyruvic acid (10-50 mg kg-1 i.p.) reduced by 16-23 min (range) the latency of the first slow-wave episode in a dose-related fashion and produced a significant increase in slow-wave sleep time (12-40%) in doses of 10-30 mg kg-1. Rapid eye movement sleep latency and rapid eye movement sleep time were increased (by 23-37 min) and reduced (57-71%) respectively. The effects of indole-pyruvic acid on slow-wave sleep time were still present after 3, 7 and 14 days of chronic administration (10 mg kg-1 day-1), whereas tolerance to the effect of indole-pyruvic acid on rapid eye movement sleep was observed. Daily food consumption was reduced (20-28%) by acute administration of indole-pyruvic acid (15-30 mg kg-1 i.p.), but tolerance developed after 5 days of repeated injections. These findings are in accordance with previous evidence suggesting that indole-pyruvic acid effects may be related to the activation of central serotonin neurons, which are involved in the inhibitory control of sleep and food intake.

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“…1989) and in the rat. The effect of SHT2 receptor antagonists on REM sleep is less clear, as some (Sommerfeldt et al 1987;Borbely et a1. 1988;Tortella et a1.…”

mentioning

confidence: 99%

Effects of 5HT3 Receptor Antagonism by Tropisetron on the Sleep EEG and on Nocturnal Hormone Secretion

Rothe

Güldner

Hohlfeldt

et al. 1994

Neuropsychopharmacol

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Two dosages (5 mg and 25 mg) of the selective 5HT3 receptor antagonist tropisetron (lCS 205-930) were administered to healthy male controls, and the effects on the sleep EEG and nocturnal secretory activity of growth hormone (GH) and cortisol were evaluated. The lower dosage was administered to four subjects and the higher dosage to eight on 5 consecutive days, preceded and followed by 2 days of placebo treatment. After 25 mg of tropisetron, there was a slight increase in REM sleep in the first part of the sleep period, and stage 2 was decreased during the total night. In addition, plasma cortisol levels increased earlier than under placebo, and plasma GH levels were reduced in the second part of the night. Thus, only discrete effects of tropisetron upon sleep-endocrine activity were noted, making it unlikely that serotoninergic neurotransmission exerts its well documented effects upon sleep through 5HT3 receptors.

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Similar effect on REM sleep but differential effect on slow wave sleep of the two 5-HT uptake inhibitors zimeldine and alaproclate in cats and rats

Cited by 26 publications

References 44 publications

Homeostatic Regulation of Serotonergic Function by the Serotonin Transporter As Revealed by Nonviral Gene Transfer

Homeostatic Regulation of Serotonergic Function by the Serotonin Transporter As Revealed by Nonviral Gene Transfer

Effects of indole‐pyruvic acid on sleep and food intake in the rat

Effects of 5HT3 Receptor Antagonism by Tropisetron on the Sleep EEG and on Nocturnal Hormone Secretion

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