Similar donors—similar blood?

Tarasev, Michael; Alfano, K.; Chakraborty, Sumita; Light, Lucia; Doeden, Kim; Gorlin, Jed B.

doi:10.1111/trf.12457

Cited by 28 publications

(33 citation statements)

References 34 publications

(58 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study demonstrates a strong dependence of the recipients’ ∆SBF on the PRBC deformability per se, thereby providing direct evidence that the deformability of transfused RBC is a potent determinant of skin blood perfusion in transfusion recipients. Notably, this study reveals a large variability in RBC deformability between donors, concordant with previous studies reporting a large in‐donor variability in PRBC properties . Specifically, RBC deformability has been previously shown to differ significantly with donors’ sex, age, and health conditions .…”

Section: Discussionsupporting

confidence: 90%

Deformability of transfused red blood cells is a potent determinant of transfusion‐induced change in recipient's blood flow

et al. 2016

View full text Add to dashboard Cite

This study provides, for the first time in humans, direct evidence that the deformability of transfused PRBC is a potent effector of transfusion outcome. Currently, PRBC are supplied primarily by the first-in-first-out criteria, while their functionality is ignored. The testing of PRBC hemodynamic quality would introduce a new paradigm into blood banking, which would contribute substantially to improving transfusion therapy.

show abstract

Section: Discussionsupporting

confidence: 90%

Deformability of transfused red blood cells is a potent determinant of transfusion‐induced change in recipient's blood flow

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown statistically significant differences, and thus inter-donor variability, in RBC mechanical fragility (MF), % hemolysis, and Mean Corpuscular Volume (MCV) [13]. Our studies expand on this finding by not only correlating bulk mechanical properties, like filterability, with inter-donor variability in the mechanical properties of red cells, but also by providing a mathematically determined quantitative metric for testing red cell mechanical properties.…”

Section: Discussionmentioning

confidence: 60%

“…Using this method, we measured the inter-donor variability as well as deterioration rate of RBCs’ mechanical properties. There are only attempts to correlate the mechanical and biochemical changes that occur during storage with inter-donor variability [13]. This manuscript reports our findings on the biochemical and mechanical properties of human RBCs with in vitro RBC quality assays.…”

Section: Introductionmentioning

confidence: 93%

“…Storage lesion reduces post-transfusion RBC survival and has been linked to a variety of adverse side effects such as microcirculatory complications, transfusion-related acute lung injury (TRALI), inflammation, organ failure, and mortality [10] [11, 12]. Current studies are beginning to use time-independent metrics to predict the survival rate of transfused blood based on findings that suggest inter-donor variability as a factor of the rate of the development of storage lesion [13]. The mechanical deterioration of RBCs during storage stems from changes in shape, deformability, and aggregability [14, 15], while biochemical changes in ATP, lactate, hemoglobin (Hb), potassium, and 2,3-DPG levels are believed to account for the remaining segments of storage lesion [16].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Blood Quality Diagnostic Device Detects Storage Differences Between Donors

Jani

Mailo

Athar

et al. 2017

IEEE Trans. Biomed. Circuits Syst.

View full text Add to dashboard Cite

In 2013, nearly 15 million units of banked blood were transfused in the United States alone. Blood shortages are expected to increase globally. Donated blood is not equal due to differences in quality and deterioration rate. There are no methods to detect time-dependent biochemical and biophysical changes of RBCs or the deterioration rate of donated RBCs. Nine randomly selected RBC units collected by the San Diego Blood Bank were examined for inter-donor variability over six weeks of storage. In vitro RBC quality was assessed weekly by conventional biochemical tests including free Hb, K+, ATP, P50, 2,3 DPG, lactate, and pH. Deformability was measured via cell filtration. Briefly, the RBC suspension (10% Hct), was forced through a 5.0μm pore membrane (106 mm2) at various flow rates. No inter-donor variability in biochemical or mechanical parameters was observed at baseline. Inter-donor variability in biochemical properties (free Hb, K+, ATP, P50, 2,3 DPG, lactate, and pH) was observed after 14 days of storage. However, significant differences from baseline in RBC mechanical properties (i.e. filterability) were observed as early as 7 days into storage at the lowest flow rates and after 28 days of storage at all flow rates. There was a net decrease in filterability over time for all donors, but the rate at which filterability decreased (i.e. deterioration rates) was different when comparing individual donors. Changes in all biochemical parameters were significant different between donors. These data suggest that filterability is more sensitive to changes in blood quality than conventional biochemical parameters.

show abstract

“…In RBCs given by blood donors in two draws, intra-individual as well as inter-individual variation of auto-hemolysis and stress induced hemolysis was seen [26]. Beside age, other factors such as variability in ATP levels differ from person to person [27].…”

Section: Pharmacology Of Cellular Blood Products and Transfusion Triggermentioning

confidence: 99%