Similar Depletion of Protective<i>Faecalibacterium prausnitzii</i>in Psoriasis and Inflammatory Bowel Disease, but not in Hidradenitis Suppurativa

Eppinga, Hester; Weiland, Christa J. Sperna; Thio, Hok Bing; Woude, C. Janneke van der; Nijsten, Tamar; Peppelenbosch, Maikel P.; Konstantinov, Sergey R.

doi:10.1093/ecco-jcc/jjw070

Cited by 166 publications

(160 citation statements)

References 31 publications

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“…49 Decreased F. prausnitzii prevalence in stool has recently been reported in patients with psoriasis. 50 This observation supports the possibility that psoriasis is also associated with important shifts in the composition of the gastrointestinal microbiome.…”

Section: Psoriasis Pathophysiology: the Role Of Bacteriasupporting

confidence: 68%

“…Interestingly, a reduction in Faecalibacterium prausnitzii , a member of the gastrointestinal Firmicutes phyla, was associated with an increased risk of postoperative disease relapse . Decreased F. prausnitzii prevalence in stool has recently been reported in patients with psoriasis . This observation supports the possibility that psoriasis is also associated with important shifts in the composition of the gastrointestinal microbiome.…”

Section: Psoriasis Pathophysiology: the Role Of Bacteriamentioning

confidence: 78%

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The role of the microbiome in psoriasis: moving from disease description to treatment selection?

et al. 2018

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Section: Psoriasis Pathophysiology: the Role Of Bacteriasupporting

confidence: 68%

Section: Psoriasis Pathophysiology: the Role Of Bacteriamentioning

confidence: 78%

The role of the microbiome in psoriasis: moving from disease description to treatment selection?

et al. 2018

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“…In addition, the relation between the gut microbiome in inflammatory bowel disease and response to infliximab was also recently highlighted 90. In particular, when considering the reports about the role of the gut‐skin axis that might influence many diseases including the here investigated skin disorders 91, 92, 93.…”

Section: Discussionmentioning

confidence: 82%

A systematic literature review of the human skin microbiome as biomarker for dermatological drug development

Kolk

Wall

Balmforth

et al. 2018

Brit J Clinical Pharma

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AimsTo explore the potential of the skin microbiome as biomarker in six dermatological conditions: atopic dermatitis (AD), acne vulgaris (AV), psoriasis vulgaris (PV), hidradenitis suppurativa (HS), seborrhoeic dermatitis/pityriasis capitis (SD/PC) and ulcus cruris (UC).MethodsA systematic literature review was conducted according to the PRISMA guidelines. Two investigators independently reviewed the included studies and ranked the suitability microbiome implementation for early phase clinical studies in an adapted GRADE method.ResultsIn total, 841 papers were identified and after screening of titles and abstracts for eligibility we identified 42 manuscripts that could be included in the review. Eleven studies were included for AD, five for AV, 10 for PV, two for HS, four for SD and 10 for UC. For AD and AV, multiple studies report the relationship between the skin microbiome, disease severity and clinical response to treatment. This is currently lacking for the remaining conditions.ConclusionFor two indications – AD and AV – there is preliminary evidence to support implementation of the skin microbiome as biomarkers in early phase clinical trials. For PV, UC, SD and HS there is insufficient evidence from the literature. More microbiome‐directed prospective studies studying the effect of current treatments on the microbiome with special attention for patient meta‐data, sampling methods and analysis methods are needed to draw more substantial conclusions.

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“…Faecalibacterium prausnitzii depletion and Escherichia coli increase are well‐documented among patients with IBD. However, in patients with HS and no concomitant bowel disease, no meaningful difference in F. prausnitzii or E. coli abundance was found . Bacteria seem to play a significant role in the development of HS.…”

Section: Methodsmentioning

confidence: 99%

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

Polkowska-Pruszyńska

Gerkowicz

Krasowska

2019

Acad Dermatol Venereol

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The human microbiome is a wide range of microorganisms residing in and on our body. The homeostasis between host immune system and the microbial environment allows mutual benefits and protection. Physiological bacterial colonization is essential for the establishment of organism immunity. The human microbiota ecosystem can be divided into several compartments, out of which intestinal flora strongly affects our health and plays a crucial role in the pathophysiology of many diseases. The gastrointestinal tract, being a major guardian of the immune system, maintains the homeostasis with the commensal microorganisms by tolerating the typical flora antigens. The dysbiosis may trigger an inflammatory response followed by tissue damage or autoimmune processes. The gut microbiome alterations are linked to the pathogenesis of the allergic, cardiovascular, gastrointestinal, metabolic, neurodevelopmental, psychiatric and neurodegenerative diseases and cancer. Moreover, there is increasing evidence connecting the skin condition with the gastrointestinal microbiome, which has been described as the skin–gut axis. The aim of this study was to review the literature regarding the role of the gut microbiome alterations in the pathogenesis of selected allergic and inflammatory skin diseases.

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Similar Depletion of ProtectiveFaecalibacterium prausnitziiin Psoriasis and Inflammatory Bowel Disease, but not in Hidradenitis Suppurativa

Abstract: The study demonstrates, for the first time, an IBD-like decrease of F. prausnitzii together with an increase of E.coli in psoriasis, supporting the presence of a gut-microbiome-skin axis in psoriasis and IBD.

Cited by 166 publications

References 31 publications

The role of the microbiome in psoriasis: moving from disease description to treatment selection?

The role of the microbiome in psoriasis: moving from disease description to treatment selection?

A systematic literature review of the human skin microbiome as biomarker for dermatological drug development

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

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