Similar colds in subjects with allergic asthma and nonatopic subjects after inoculation with rhinovirus-16

DeMore, Jennifer; Weisshaar, Elizabeth; Vrtis, Rose F.; Swenson, Cheri A.; Evans, Michael D.; Morin, Allison; Hazel, Elizabeth; Bork, Jack A.; Kakumanu, Sujani; Sorkness, Ronald L.; Busse, William W.; Gern, James E.

doi:10.1016/j.jaci.2009.05.030

Cited by 91 publications

(114 citation statements)

References 28 publications

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“…29 Severe exacerbations are primarily related to viral infections. 30 Increased baseline sputum eosinophil values were related to more severe symptoms in respect to experimental rhinovirus infection, 31 which might support our findings on the relation between increased B-Eos values and asthma-related ED visits.…”

Section: Discussionsupporting

confidence: 81%

Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects

Malinovschi¹,

Fonseca²,

Jacinto³

et al. 2013

Journal of Allergy and Clinical Immunology

226

158

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Background: Fraction of exhaled nitric oxide (FENO) and blood eosinophil count (B-Eos) values, markers of local and systemic eosinophilic inflammation, respectively, are increased in asthmatic patients. Little is known about the relation of these markers to reported wheeze and asthma events in a random population sample. Objectives: We sought to determine the individual and independent values of B-Eos and FENO in relation to wheeze, asthma diagnosis, and asthma events in a cross-sectional study. 3 ) values rendered an adjusted odds ratio of 4.5 of having wheeze, 5.1 of having asthma, 5.4 for asthma attacks, and 2.9 for asthma-related ED visits compared with normal FENO (<25 ppb) and B-Eos (<300 cells/mm

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Section: Discussionsupporting

confidence: 81%

Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects

Malinovschi¹,

Fonseca²,

Jacinto³

et al. 2013

Journal of Allergy and Clinical Immunology

226

158

View full text Add to dashboard Cite

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“…Details of the outcomes study have been published. (25) Protocols were reviewed and approved by the Harvard School of Public Health and the University of Wisconsin Institutional Review Boards for Human Subject Protection. Informed consent was obtained from all patients after the study goals and procedures were explained in detail.…”

Section: Exhaled Breath Particles From Hrv-infected Subjectsmentioning

confidence: 99%

Origin of Exhaled Breath Particles from Healthy and Human Rhinovirus-Infected Subjects

Fabian¹,

Brain²,

Houseman

et al. 2011

Journal of Aerosol Medicine and Pulmonary Drug Delivery

149

158

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Background: Exhaled breath studies suggest that humans exhale fine particles during tidal breathing, but little is known of their physical origin in the respiratory system during health or disease. Methods: Particles generated by 3 healthy and 16 human rhinovirus (HRV)-infected subjects were counted using an optical particle counter with nominal diameter-size bins ranging between 0.3 and 10 mm. Data were collected from HRV-infected subjects during tidal breathing. In addition, data from healthy subjects were collected during coughs, swallows, tidal breathing, and breathing to total lung capacity (TLC) and residual volume (RV). Using general additive models, we graphed exhaled particle concentration versus airflow during exhalation. Exhaled particles were collected from expired air on gelatin filters and analyzed for HRV via quantitative PCR. Results: HRV-infected subjects exhaled from 0.1 to 7200 particles per liter of exhaled air during tidal breathing (geometric mean ¼ 32 part/L). A small fraction (24%) of subjects exhaled most (81%) of the particles measured and 82% of particles detected were 0.300-0.499 mm. Minute ventilation, maximum airflow during exhalation, and forced expiratory volume 1 second (FEV 1 % predicted) were positively correlated with particle production. No human rhinovirus was detected in exhaled breath samples. Three healthy subjects exhaled less than 100 particles per liter of exhaled air during tidal breathing and increased particle concentrations more with exhalation to RV than with coughing, swallowing, or rapid exhalation. Conclusions: Submicron particles were detected in the exhaled breath of healthy and HRV-infected subjects. Particle concentrations were correlated with airflow during the first half of exhalation, and peaked at the end of exhalation, indicating both lower and upper airways as particle sources. The effect of breathing maneuver suggested a major contribution from lower airways, probably the result of opening collapsed small airways and alveoli.

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“…Our data indicate that the increase of a specific profile of DAMPs rather than that of HMGB1 alone, which has been implicated in COPD development [6], may be an important determinant of the susceptibility towards neutrophilic airway inflammation upon cigarette smoking.In future studies it will be of interest to confirm whether a similar DAMP release signature is present in COPD patients, whether this is related to the susceptibility of smoking individuals to develop COPD and whether this signature can be used for the early detection of susceptibility to or the presence of COPD. @ERSpublications A specific profile of DAMPs identifies susceptibility towards smoke induced neutrophilic airway inflammation in mice…”

mentioning

confidence: 77%

mentioning

confidence: 77%

Experimental rhinovirus 16 infection in moderate asthmatics on inhaled corticosteroids

Adura

Reed

Macintyre

et al. 2013

European Respiratory Journal

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neutrophilic airway inflammation. Our data indicate that the increase of a specific profile of DAMPs rather than that of HMGB1 alone, which has been implicated in COPD development [6], may be an important determinant of the susceptibility towards neutrophilic airway inflammation upon cigarette smoking.In future studies it will be of interest to confirm whether a similar DAMP release signature is present in COPD patients, whether this is related to the susceptibility of smoking individuals to develop COPD and whether this signature can be used for the early detection of susceptibility to or the presence of COPD. @ERSpublications A specific profile of DAMPs identifies susceptibility towards smoke induced neutrophilic airway inflammation in mice

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Similar colds in subjects with allergic asthma and nonatopic subjects after inoculation with rhinovirus-16

Abstract: Background-Rhinovirus infections are frequent causes of asthma exacerbations.

Cited by 91 publications

References 28 publications

Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects

Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects

Origin of Exhaled Breath Particles from Healthy and Human Rhinovirus-Infected Subjects

Experimental rhinovirus 16 infection in moderate asthmatics on inhaled corticosteroids

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