Simiao San alleviates hyperuricemia and kidney inflammation by inhibiting NLRP3 inflammasome and JAK2/STAT3 signaling in hyperuricemia mice

Zhang, Yueyi; Wang, Shan; Xuan, Dong; Liu, Tianyuan; Liu, Yage; Shi, Hanfen; Yin, Jiyuan; Xu, Tianshu; Zhang, Yanfei; Zhao, Dandan; Sukhorukov, Vasily N.; Orekhov, Alexander N.; S, Gao; Wang, Lili; Zhang, Dongwei

doi:10.1016/j.jep.2023.116530

Cited by 10 publications

(9 citation statements)

References 54 publications

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“…Subsequently, the results showed that SMS treatment decreased the serum UA, BUN, and Cr levels, increased urine UA levels, and relieved the pathological injuries of renal tissues in hyperuricemic rats, which were in line with prior findings (Zhang et al, 2023). Notably, SMS treatment decreased the XO activity in the serum and hepatic tissues of hyperuricemic rats, which was consistent with previous research (Zhang et al, 2023).…”

Section: Discussionsupporting

confidence: 90%

“…TCM has been extensively applied for thousands of years in China and is regarded as a valuable medical approach characterized by enhanced efficacy and reduced side effects (Tang et al, 2023). SMS, a renowned traditional Chinese formula, is clinically applied for the treatment of hyperuricemia (Zhang et al, 2023). Modern pharmacological research indicates the anti-hyperuricemia role of SMS by regulating multiple pathways and targets (Zeng et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Modern pharmacological research indicates the anti‐hyperuricemia role of SMS by regulating multiple pathways and targets (Zeng et al, 2021). An increasing number of in vivo studies revealed its anti‐inflammatory, UA‐lowering, and kidney‐protective effects in the treatment of hyperuricemia (Cao et al, 2021; Shui et al, 2022; Zhang et al, 2023). Nevertheless, there remains a lack of understanding about the therapeutic mechanisms of SMS against hyperuricemia, especially with regard to the gut microbiome.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study has indicated the anti-hyperuricemia effects of SMS in hyperuricemic mice (Cao et al, 2021). Interestingly, the latest research shows that SMS intervention can effectively mitigate hyperuricemia and renal inflammation in hyperuricemic mice by suppressing NLRP3 (NLR family pyrin domain containing 3) inflammasome and the JAK2/STAT3 (Janus kinase 2/signal transducer and activator of transcription 3) axis (Zhang et al, 2023). Another study demonstrated that SMS can inhibit the activation of NLRP3 inflammasome to suppress epithelial-mesenchymal transition in mice with chronic hyperuricemic nephropathy (Shui et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

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Si Miao San relieves hyperuricemia by regulating intestinal flora

Qian,

Shen

2023

Biomedical Chromatography

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This study seeks to investigate the therapeutic effects of Si Miao San (SMS) on hyperuricemia and its underlying mechanisms, particularly focusing on the role of intestinal flora. The key components of SMS were identified using high‐performance liquid chromatography (HPLC). To establish a rat model of hyperuricemia, an intraperitoneal injection of potassium oxonate was performed, followed by oral administration of various concentrations of SMS. The study evaluated the status of hyperuricemia, renal pathology, xanthine oxidase (XO) activity, and intestinal flora. Utilizing HPLC, we identified five active components of SMS. Following SMS intervention, there was a significant reduction in serum levels of uric acid (UA), blood urea nitrogen, and creatinine, accompanied by an increase in urine UA levels in rats with hyperuricemia. Distinct pathological injuries were evident in the renal tissues of hyperuricemic rats, and these were partially alleviated following SMS intervention. Moreover, SMS exhibited a dose‐dependent reduction in XO activity both in the serum and hepatic tissues. Notably, SMS contributed to an enhancement in the diversity of intestinal flora in hyperuricemic rats. The intervention of SMS resulted in a reduction in the abundance of certain bacterial species, including Parabacteroides johnsonii, Corynebacterium urealyticum, and Burkholderiales bacterium. This suggests that SMS may exert anti‐hyperuricemia effects, potentially by modulating the composition of intestinal flora.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Si Miao San relieves hyperuricemia by regulating intestinal flora

Qian,

Shen

2023

Biomedical Chromatography

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“…In cell and animal models, IL-22 has been shown to reduce the sodium oxalate-induced NLRP3 inflammasome and mature IL-1β expression in kidney tissue and ROS accumulation, mitochondrial damage, and renal tubular epithelial cell death by decreasing the serum levels of IL-1β, IL-18, TNF-α and other cytokines ( 74 ). Hyperuricemia induces a pro-inflammatory microenvironment with increased serum levels of IL-1β, IL-6 and TNF-α, elevates renal expression of NLRP3 and cleaved caspase-1, and leads to microstructural kidney disorders in mice; Simiao San alleviates hyperuricemia and renal inflammation by inhibiting the NLRP3 inflammasome and the JAK2/STAT3 signaling pathway ( 75 ).…”

Section: The Various Forms Of Cell Death and Urolithiasismentioning

confidence: 99%

Cell death‑related molecules and targets in the progression of urolithiasis (Review)

Wu,

Xue,

et al. 2024

Int J Mol Med

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Urolithiasis is a high-incidence disease caused by calcium oxalate (mainly), uric acid, calcium phosphate, struvite, apatite, cystine and other stones. The development of kidney stones is closely related to renal tubule cell damage and crystal adhesion and aggregation. Cell death, comprising the core steps of cell damage, can be classified into various types (i.e., apoptosis, ferroptosis, necroptosis and pyroptosis). Different crystal types, concentrations, morphologies and sizes cause tubular cell damage via the regulation of different forms of cell death. Oxidative stress caused by high oxalate or crystal concentrations is considered to be a precursor to a variety of types of cell death. In addition, complex crosstalk exists among numerous signaling pathways and their key molecules in various types of cell death. Urolithiasis is considered a metabolic disorder, and tricarboxylic acid cycle-related molecules, such as citrate and succinate, are closely related to cell death and the inhibition of stone development. However, a literature review of the associations between kidney stone development, metabolism and various types of cell death is currently lacking, at least to the best of our knowledge. Thus, the present review summarizes the major advances in the understanding of regulated cell death and urolithiasis progression.

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Fuling-Zexie formula attenuates hyperuricemia-induced nephropathy and inhibits JAK2/STAT3 signaling and NLRP3 inflammasome activation in mice

Lu,

Yin,

et al. 2024

Journal of Ethnopharmacology

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Simiao San alleviates hyperuricemia and kidney inflammation by inhibiting NLRP3 inflammasome and JAK2/STAT3 signaling in hyperuricemia mice

Cited by 10 publications

References 54 publications

Si Miao San relieves hyperuricemia by regulating intestinal flora

Si Miao San relieves hyperuricemia by regulating intestinal flora

Cell death‑related molecules and targets in the progression of urolithiasis (Review)

Fuling-Zexie formula attenuates hyperuricemia-induced nephropathy and inhibits JAK2/STAT3 signaling and NLRP3 inflammasome activation in mice

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