Simian-Type Blood Groups of Nonhuman Primates

Socha, W. W.

doi:10.1007/978-3-642-59086-3_9

Cited by 2 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We chosc to study the distribution of the i antigen and of the H antigcn. Rhesus macaques arc all of the i phcnotypc in the li system (Socha, 1986). As in humans, no expression of the i antigen was observed in the digestive tract of macaque monkcys (data nor shown).…”

Section: Rutor Couedegcourteille Guillet Venetmentioning

confidence: 72%

See 1 more Smart Citation

Differential distribution of galactosylceramide, H antigen, and carcinoembryonic antigen in rhesus macaque digestive mucosa.

Butor¹,

Couëdel-Courteille²,

Guillet³

et al. 1996

J Histochem Cytochem.

View full text Add to dashboard Cite

The most common route of transmission of HIV is via the mucosa. We compared human and macaque intestinal epithelia to determine whether the SIV macaque system can be used as a model to study HIV transmission by the rectal route. The overall morphology of the macaque gut mucosa is very similar to that of humans. Differentiation markers follow the same pattern as in the human system. The carcinoembryonic antigen (CEA) is apical in epithelial cells of the rectum and is absent from the small intestine. Blood group H antigen is expressed by enterocytes but not by colonocytes or rectocytes. Galactosylceramide, a potential alternative receptor for HIV in epithelial cells, is expressed in all intestinal segments as in humans. In absorptive cells it is apical and intracellular in the rectum, colon, and cecum, whereas it is only intracellular in small intestine. In goblet cells the galactosylceramide is present in intracellular vacuoles in all segments. It is also present on the membrane of mucous granules in colon and small intestine but not in rectum. We therefore believe that the macaque digestive tract may constitute a good model for the human digestive tract in the transmission of lentiviruses.

show abstract

Section: Rutor Couedegcourteille Guillet Venetmentioning

confidence: 72%

“…Rhesus macaqua ocprcss the A B 0 blood group antigens in their tissucs but not on their blood cells (Moor-Jankowski, 1993). The vast majority of them are of the B phenotype (Socha, 1986). but some are of the 0 or A phenotype (Socha.…”

Section: Rutor Couedegcourteille Guillet Venetmentioning

confidence: 98%

Differential distribution of galactosylceramide, H antigen, and carcinoembryonic antigen in rhesus macaque digestive mucosa.

Butor¹,

Couëdel-Courteille²,

Guillet³

et al. 1996

J Histochem Cytochem.

View full text Add to dashboard Cite

show abstract

Anti‐human red cell monoclonal antibodies produced by macaque–mouse heterohybridomas: Their reactivity with human and nonhuman primate erythrocytes

Blancher

Roubinet²,

Reld

et al. 1999

J of Medical Primatology

View full text Add to dashboard Cite

Eighteen monoclonal antibodies (Mabs) against human red blood cells (RBCs) produced by macaque mouse heterobybridomas gave uniformly positive reactions with all human samples except for some with particular null phenotypes. Based on reactions with latter cells, the human antigenic targets of 11 antibodies could be identified: six were specific for glycophorin-related antigens (Wr(b), En(a), Ge4), and each of the live remaining antibodies showed one of the following specificities: CD55, CD44, CD59, Kell, and Rh proteins. Four Mabs recognized the Vc antigen of the chimpanzee V-A-B-D system. Six macaque Mabs detected polymorphisms in chimpanzee, gorilla, orangutan, and gibbon that did not correspond to any known blood group in these animals, while other Mabs gave monomorphic reactions with ape RBCs. The reagents produced by macaque hybridomas are useful tools not only for human blood grouping tests, but also for tracing the relationships among blood group antigens of man and anthropoid apes.

show abstract

Simian-Type Blood Groups of Nonhuman Primates

Cited by 2 publications

References 24 publications

Differential distribution of galactosylceramide, H antigen, and carcinoembryonic antigen in rhesus macaque digestive mucosa.

Differential distribution of galactosylceramide, H antigen, and carcinoembryonic antigen in rhesus macaque digestive mucosa.

Anti‐human red cell monoclonal antibodies produced by macaque–mouse heterohybridomas: Their reactivity with human and nonhuman primate erythrocytes

Contact Info

Product

Resources

About