Simamycin (5′-O-geranyluridine): a new prenylated nucleoside from Streptomyces sp.

Abstract

A new nucleoside modified by prenylation, simamycin (1), was isolated from the culture broth of a soil-derived Streptomyces sp. Its structure was determined by spectroscopic analysis and chemical synthesis as 5′-O-geranyluridine. Compound 1 induced differentiation of preadipocytes into matured adipocytes.