Silymarin regulates the cytochrome P450 3A2 and glutathione peroxides in the liver of streptozotocin-induced diabetic rats

Malekinejad, Hassan; Rezabakhsh, Aysa; Rahmani, Fatemeh; Hobbenaghi, Rahim

doi:10.1016/j.phymed.2012.02.009

Cited by 48 publications

(34 citation statements)

References 32 publications

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“…It is known that selenium plays a significant role in glutathione peroxidase, lipooxigenase pathway, organic antioxidant systems and vitamin A, E and C (Navarro and Lopez, 2000). Silymarin regulates the cytochrome P450 3A2 and glutathione peroxides in the liver of streptozotocin-induced diabetic rats (Malekinejad et al, 2012). In the present study, a Science Publications AJAVS 4.5% decrease in serum selenium levels was observed in the diabetic control group.…”

Section: Discussionsupporting

confidence: 54%

The Effects of Oral Administration of Different Doses of Hydroalcoholic Extract of Silymarin on Status of Serum Trace Elements

Sajedianfard¹,

Nazifi²,

Shamsaei³

2014

American Journal of Animal and Veterinary Sciences

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In this research, the effect of oral administration of different doses of hydroalcoholic extract of silymarin on the status of trace elements with antioxidant properties (Se, Cu, Zn, Mn and Fe) was studied. Fifty male rats were randomly used in five groups including healthy control group (treated by saline), diabetic control group (treated by saline) and three diabetic groups that were daily treated by different oral dose of silymarin (100, 175 and 250 mg kg −1 ). Diabetes was induced by intraperitoneal injection of streptozotocin (50 mg kg −1 ) in rats. Rats were orally treated for 14 days by gavage. Weight was measured before STZ injection, 7 and 14 days after treatment. The blood glucose was measured before injection of STZ, 3 days after injection and 7 and 14 days after diabetes was induced (under treatment by silymarin). At the end of the study, blood samples were taken by heart puncture. Results showed that the average weight increased during the 14 days of treatment with silymarin and the blood glucose was decreased. Hydroalcoholic extract of silymarin increased trace elements levels in treated groups by dose-dependent manner. The present study showed that in diabetic rats, high therapeutic doses of silymarin had a major effect on serum antioxidant factors. Results also showed that hydroalcoholic extract of silymarin increased the body weight and decreased serum glucose concentration at the end of the treatment period. Silymarin in a dose dependent manner could improve trace element levels in diabetic rats. Therefore, it may cause reduction of oxidative stress in the diabetic rats.

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Section: Discussionsupporting

confidence: 54%

The Effects of Oral Administration of Different Doses of Hydroalcoholic Extract of Silymarin on Status of Serum Trace Elements

Sajedianfard¹,

Nazifi²,

Shamsaei³

2014

American Journal of Animal and Veterinary Sciences

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“…17 In contrast, Vornoli et al found no signicant change on protein levels of hepatic CYP 3A2 in HFD/STZ treated Wistar rats.…”

Section: Effect Of Rtlw and Rtle On Phase I Enzymes In Liver Of Hfd/smentioning

confidence: 94%

Protective effect of Ruellia tuberosa L. extracts against abnormal expression of hepatic detoxification enzymes in diabetic rats

et al. 2018

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Ruellia tuberosa L. (RTL) has been used as a folk medicine for curing diabetes mellitus in East Asia decades. This study investigated the effect of RTL on hepatic detoxification enzyme expression in diabetic rats. Male Wistar rats were fed a high fat diet (HFD) and intraperitoneally injected with streptozotocin (STZ) to induce diabetes. Subsequently, rats received oral administrations of 100 or 400 mg kg À1 body weight RTL extract, in either water (RTLW) or ethanol (RTLE), once a day for 4 weeks. The real-time PCR analyses showed that abnormality of hepatic phase I and II detoxification enzyme expression was observed in diabetic rats. However, both RTLW and RTLE significantly normalized the expression of hepatic phase I detoxification enzymes such as CYP 2E1, and expression of phase II detoxification enzymes such as UGT 1A7 and GST M1 in diabetic rats. Furthermore, we found that fasting serum glucose, hemoglobin A1C (HbA1C) and the area under the curve of oral glucose tolerance test (AUC OGTT ) levels were significantly reduced in both RTLW and RTLE treated diabetic rats.Moreover, both RTLW and RTLE significantly increased the activity of hepatic anti-oxidative enzymes such as superoxide dismutase (SOD) in diabetic rats. The present study suggests that RTL may ameliorate abnormal hepatic detoxification function via alleviating hyperglycemia and enhancing hepatic antioxidant capacity in HFD/STZ-induced diabetic rats.

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“…Previously we showed that in diabetic rats, one of the most active systems in drug and xenobiotics metabolizing is activated in the liver (Malekinejad et al, 2012). We also showed that the up regulation of the drug metabolizing enzymes is not limited to mRNA level but also its enzymatic function in the biotransformation of natural substrate augmented (Malekinejad et al, 2014).…”

Section: Discussionmentioning

confidence: 83%

Atorvastatin up-regulates the expression and activity of renal Cytochrome P450 3A2 in diabetic rats

Malekinejad

Alizadeh-Fanalou

Hobbenaghi

et al. 2016

JAB

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Silymarin regulates the cytochrome P450 3A2 and glutathione peroxides in the liver of streptozotocin-induced diabetic rats

Cited by 48 publications

References 32 publications

The Effects of Oral Administration of Different Doses of Hydroalcoholic Extract of Silymarin on Status of Serum Trace Elements

The Effects of Oral Administration of Different Doses of Hydroalcoholic Extract of Silymarin on Status of Serum Trace Elements

Protective effect of Ruellia tuberosa L. extracts against abnormal expression of hepatic detoxification enzymes in diabetic rats

Atorvastatin up-regulates the expression and activity of renal Cytochrome P450 3A2 in diabetic rats

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