Silymarin-Loaded Tin(IV) Nanoparticles Exhibit Enhanced Bioavailability and Antiproliferative Effects on Colorectal Cancer Cells
Hossein Abbasinia,
Masoumeh Heshmati,
Mohammad Yousefi
et al.
Abstract:Silymarin (SM) exhibits potential therapeutic effects due to having antioxidant activity. However, the low solubility and bioavailability of SM restrict its biological performance. To overcome this limitation, this study aimed to develop a nanoformulation composed of SM and dimethyltindichloride and investigate the effect of SM-loaded Sn nanoparticles on cancer cell growth and survival. An SM−Sn complex was synthesized and then characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM)… Show more
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