Silymarin and milk thistle extract may prevent the progression of diabetic nephropathy in streptozotocin-induced diabetic rats

Vessal, Ghazal; Akmali, Masoumeh; Najafi, Parisa; Moein, Mahmood Reza; Sagheb, Mohammad Mahdi

doi:10.3109/0886022x.2010.486488

Cited by 51 publications

(26 citation statements)

References 33 publications

(36 reference statements)

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“…In the same paper, Khazim et al [147] obtained similar results in an in vivo experiment using 100 mg/kg/day of same substance (i.p., six weeks) in an advanced new model of diabetic nephropathy (OVE26 mice) with an additional reduction in albuminuria. These data also corroborated the findings of Vessal et al [148], who used silymarin (100 mg/kg/day, i.p., for four weeks) in an STZ-rat model to obtain a reduction in kidney lipid peroxidation and increase the activity of catalase and GPx under hyperglycemia conditions.…”

Section: Potential Of Natural Products With Antioxidant Effects Fosupporting

confidence: 92%

Coadjuvants in the Diabetic Complications: Nutraceuticals and Drugs with Pleiotropic Effects

Pereira

Pimenta

Porto

et al. 2016

IJMS

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Because diabetes mellitus (DM) is a multifactorial metabolic disease, its prevention and treatment has been a constant challenge for basic and clinical investigators focused on translating their discoveries into clinical treatment of this complex disorder. In this review, we highlight recent experimental and clinical evidences of potential coadjuvants in the management of DM, such as polyphenols (quercetin, resveratrol and silymarin), cultured probiotic microorganisms and drugs acting through direct/indirect or pleiotropic effects on glycemic control in DM. Among several options, we highlight new promising therapeutic coadjuvants, including chemical scavengers, the probiotic kefir and the phosphodiesterase 5 inhibitors, which besides the reduction of hyperglycemia and ameliorate insulin resistance, they reduce oxidative stress and improve endothelial dysfunction in the systemic vascular circulation. In the near future, experimental studies are expected to clear the intracellular pathways involving coadjuvants. The design of clinical trials may also contribute to new strategies with coadjuvants against the harmful effects of diabetic complications.

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Section: Potential Of Natural Products With Antioxidant Effects Fosupporting

confidence: 92%

Coadjuvants in the Diabetic Complications: Nutraceuticals and Drugs with Pleiotropic Effects

Pereira

Pimenta

Porto

et al. 2016

IJMS

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“…In a study conducted similar to our results, insignificant differences was found in serum MDA of ducks fed with SFO diet [32] . It is known that Slybum marianum extracts and active substances like silymarin show antioxidant characteristics and inhibit oxidative stress in various tissues such as liver, kidney, brain of rats [5,[33][34][35] . It was determined that it increased in kidneys of diabetic rats; while the use of milk thistle extracts and silymarin decreased Thiobarbituric acid reactive substances (TBARS) values in a statistically significant way, the decreased SOD, CAT, and GSHPx activities increased [34,36] .…”

Section: Discussionmentioning

confidence: 99%

Yüksek Kalorili Bıldırcın Karma Yemlerine Deve Dikeni (Silybum marianum) Tohumu İlavesinin Yumurta Verimi, Yumurta Kalite Özellikleri, Kuluçka Randımanı ve Oksidatif Stres Parametreleri Üzerine Etkisi

Erişir¹,

Mutlu²,

Şimşek³

et al. 2016

Kafkas Univ Vet Fak Derg

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The purpose of this study was to examine the changes to occur in egg production, egg quality traits, hatchability, and oxidative stress parameters of laying quails fed with high calorie diets and effect of milk thistle (Silybum marianum) seed on these changes. A total of 75 45-day-old quails including 60 females and 15 males were used in the study. The quails were divided into 5 groups with three repetitions. 4 females and 1 male were used in each repetition. The groups of the study were arranged as following; control group (C) consuming corn-soybean based basal diet, oil group (SFO) in which 5% sun flower oil was added into basal diet, oil + milk thistle group (SFO+MT) in which 5% sun flower oil + 1% milk thistle seed was added into basal diet, syrup group (CS) in which 10% corn syrup was added into basal diet, and syrup + milk thistle group (CS+MT) in which 10% corn syrup + 1% milk thistle was added into basal diet. Total egg production was found to be significantly higher in SFO and SFO+MT groups of present study (P<0.05). Feed intake, total egg weight and feed conversion were found similar among the groups (P>0.05). The differences among the groups in albumen rate, yolk rate, dried shell rate and shape index were not statistically significant (P>0.05). The best yolk colour was obtained in SFO+MT and CS groups (P<0.01). There were no statistically differences among the groups in hatchability, hatchability of fertile and embrionic mortality (P>0.05), but the difference in examined fertility were statistically significant (P<0.05). Malonyl dialdehyde (MDA) values of blood, liver and heart tissues were similar among the groups of study (P>0.05). MDA level of kidney significantly increased in CS group, however addition of milk thistle seed into diet was reduced MDA level of kidney in CS+MT group (P<0.01). High calorie diets caused changes in antioxidant system in blood and tissues. Consequently, high-calorie basal diets especially addition of SFO improved only egg production and fertility rate. However feeding quails with corn syrup had significantly higher lipid peroxidation in kidney. Supplementation of milk thistle seed into CS group may protect kidney against free radical damage. Keywords ÖzetBu araştırmada yüksek kalorili yemlerle beslenen yumurtacı bıldırcınlarda yumurta verimi, yumurta kalite özellikleri, kuluçka performansı ve oksidatif stres parametrelerinde meydana gelebilecek değişimler ve bu değişimler üzerine deve dikeni (Silybum marianum) tohumunun etkisinin incelenmesi amaçlanmıştır. Araştırmada, 45 günlük yaşta 60 adet dişi, 15 adet erkek olmak üzere toplam 75 adet bıldırcın kullanılmıştır. Araştırma 5 grup ve her grupta 3 tekerrürden oluşturulmuştur. Her bir tekerrürde 4 dişi ve 1 erkek bıldırcın kullanılmıştır. Deneme grupları; mısır-soya esasına dayalı temel karma yemi tüketen kontrol grubu (C), temel diyete % 5 ay çiçeği yağı ilave edilen yağ grubu (SFO), temel diyete %5 ay çiçeği yağı + %1 deve dikeni ilave edilen yağ + deve dikeni grubu (SFO+MT), temel diyete %10 mısır şurubu ilave ...

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“…Silymarin also reduced kidney damage and restored activities of superoxide dismutase, glutathione peroxidase and catalase enzymes in rats with alloxan-induced diabetes (33). In streptozotocininduced diabetes rats, milk thistle extract attenuated diabetic nephropathy, probably by increasing catalase and glutathione peroxidase activity and reducing lipid peroxidation in renal tissue (34).…”

Section: Discussionmentioning

confidence: 88%

Potential Renoprotective Effects of Silymarin Against Nephrotoxic Drugs: A Review of Literature

Shahbazi¹,

Dashti‐Khavidaki²,

Khalili³

et al. 2012

J Pharm Pharm Sci

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Drug-induced nephrotoxicity (DIN) accounts for up to sixty percent of hospital acquired acute kidney injury. Several efforts have been made to reduce drug-induced renal damage; however, DIN remains a matter of concern, with substantial impact on patients and the health system. Silymarin is a drug that has been used for many years in alternate and modern medicine for treating hepatic diseases. Its antioxidant, anti-inflammatory and anti-apoptotic effects make it an interesting herbal medicine, and these properties have implicated this compound as a potential renoprotective agent. Based on the findings from animal studies, this review concluded that silymarin might exert significant protective or ameliorative effects against drug-induced kidney disease, especially against cisplatin-induced renal damage. Whether the protective administration of silymarin could be an effective clinical pharmacological strategy to prevent DIN is a question that remains to be answered in clinical trials. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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Silymarin and milk thistle extract may prevent the progression of diabetic nephropathy in streptozotocin-induced diabetic rats

Cited by 51 publications

References 33 publications

Coadjuvants in the Diabetic Complications: Nutraceuticals and Drugs with Pleiotropic Effects

Coadjuvants in the Diabetic Complications: Nutraceuticals and Drugs with Pleiotropic Effects

Yüksek Kalorili Bıldırcın Karma Yemlerine Deve Dikeni (Silybum marianum) Tohumu İlavesinin Yumurta Verimi, Yumurta Kalite Özellikleri, Kuluçka Randımanı ve Oksidatif Stres Parametreleri Üzerine Etkisi

Potential Renoprotective Effects of Silymarin Against Nephrotoxic Drugs: A Review of Literature

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