Silybum marianum (L.) Gaertn.: Traditional Uses, Phytochemistry, and Pharmacological Activities

Khatri, Deepa; Chhetri, Sumit Bahadur Baruwal; Devkota, Hari Prasad

doi:10.1007/978-981-19-6080-2_13

Cited by 1 publication

(1 citation statement)

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“…According to Khatri et al, S. marianum and its major bioactive compounds, silymarin, have shown promising results in terms of radical scavenging activity towards DPPH, ABTS +, and superoxide anion radicals, as well as good reducing power towards Fe 3+ and Cu 2+ ions determined by the FRAP and Cuprac method, respectively [ 28 ]. In order to determine the actual antioxidant capacity, it is necessary to apply tests based on different mechanisms.…”

Section: Resultsmentioning

confidence: 99%

Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress

Okiljević,

Martić,

Govedarica

et al. 2024

Pharmaceutics

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Silymarin, derived from Silybum marianum, has been used in traditional medicine for various ailments. In this study, the cardioprotective and hepatoprotective effects of silymarin against paracetamol-induced oxidative stress were examined in 28 male Swiss Webster mice, divided into four groups and treated for 7 days (via the oral route) with (a) saline 1 mL/kg (control group), (b) saline 1 mL/kg + single dose of paracetamol 110 mg/kg on the 7th day; (c) silymarin 50 mg/kg; and (d) silymarin 50 mg/kg + single dose of paracetamol 110 mg/kg on the 7th day. In vitro and in vivo antioxidant activity together with liver enzyme activity were evaluated. Histopathological and immunohistochemical assessment was performed. Silymarin mitigated paracetamol-induced liver injury by reducing oxidative stress markers such as lipid peroxidation and restoring antioxidant enzyme activity. Silymarin treatment resulted in a significant decrease in liver enzyme levels. Reduced necrosis and inflammatory infiltrate in liver tissues of silymarin-treated groups were detected as well. Immunohistochemical analysis demonstrated reduced expression of inflammatory markers (COX2, iNOS) and oxidative stress marker (SOD2) in the liver tissues of the silymarin-treated groups. Similar trends were observed in cardiac tissue. These results suggest that silymarin exerts potent hepatoprotective and cardioprotective effects against paracetamol-induced oxidative stress, making it a promising therapeutic agent for liver and heart diseases associated with oxidative damage.

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Section: Resultsmentioning

confidence: 99%