Silver-Zinc Redox-Coupled Electroceutical Wound Dressing Disrupts Bacterial Biofilm

Banerjee, Jaideep; Ghatak, Piya Das; Roy, Sashwati; Khanna, Savita; Hemann, Craig; Deng, Binbin; Das, Amitava; Zweíer, Jay L.; Wozniak, Daniel J.; Sen, Chandan K.

doi:10.1371/journal.pone.0119531

Cited by 64 publications

(71 citation statements)

References 81 publications

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“…Recent work in our laboratory shows that WED disrupts Pseudomonas aeruginosa PAO1 biofilm by a redox-sensitive pathway. 18,19 This work provides the first evidence demonstrating that the use of WED during NPWT may lower the cost of NPWT-assisted wound care. Larger randomized studies, testing this hypothesis, addressing a longer duration of wound care are warranted.…”

Section: Discussionmentioning

confidence: 85%

“…This work is based on our previous observations demonstrating improved reepithelialization and antibiofilm properties of a wireless electroceutical dressing (WED). 18,19 In this work, we tested the hypothesis that the use of the bioelectric dressing in conjunction with NPWT would allow us to reduce the dressing change frequency from three to two per week resulting in a lower cost of care without any increased incidence of complication.…”

Section: Introductionmentioning

confidence: 99%

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A Wireless Electroceutical Dressing Lowers Cost of Negative Pressure Wound Therapy

Ghatak

Schlanger

Ganesh

et al. 2015

Advances in Wound Care

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Objective: To test whether the use of a wireless electroceutical dressing (WED) (Procellera Ò ) in conjunction with a 5-day negative pressure wound therapy (NPWT) may reduce the number of dressing changes required per week with this therapy. Approach: At the Ohio State University Comprehensive Wound Center, chronic wound patients (n = 30) undergoing NPWT were randomized into two arms following consent as approved by the institutional review board. The control arm received standard of care NPWT, where the dressing change was performed thrice a week. The test arm received the same care except that the WED was added as an interface layer and dressing change was limited to twice a week. Results: A reduced cost of care was achieved using the WED in conjunction with NPWT. Despite fewer dressing changes in wounds dressed with the WED, closure outcomes were comparable with no overt signs of any wound complication, including infection. The cost of NPWT care during the week was significantly lower (from $2918 to $2346) in the WED-treated group compared with patients in the control arm. Innovation: This work introduces a novel technology platform involving a WED, which may be used in conjunction with NPWT. If used as such, NPWT is effective in decreasing the frequency of dressing change and lowering the cost of care. Conclusion: This work points toward the benefit of using the WED combined with NPWT. A larger clinical trial investigating the cost-effectiveness of WED in wound care is warranted.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

A Wireless Electroceutical Dressing Lowers Cost of Negative Pressure Wound Therapy

Ghatak

Schlanger

Ganesh

et al. 2015

Advances in Wound Care

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“…There is one FDA approved antimicrobial wound dressing (Procellera ® , Vomaris Inc.) that does not make therapeutic claims to treat biofilm, but has been shown to inhibit biofilm formation in vitro [78]. This dressing works by generating a 1 volt electric field [79] and electrodynamic forces are known to disrupt biofilm formation [80-83].…”

Section: Therapeutic Strategiesmentioning

confidence: 99%

A Formidable Foe Is Sabotaging Your Results: What You Should Know about Biofilms and Wound Healing

Barker

Khansa

2017

Plastic &Amp; Reconstructive Surgery

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Learning Objectives After reading this article, the participant should be able to: 1. Describe biofilm pathogenesis as it relates to problem wounds, 2. Understand the pre-clinical and clinical evidence implicating biofilm in problem wounds, 3. Explain the diagnostic and treatment challenges that biofilms create for problem wounds, 4. Demonstrate a basic understanding of emerging strategies aimed at counteracting these processes. Summary Biofilm represents a protected mode of growth for bacteria, allowing them to evade standard diagnostic techniques and avoid eradication by standard therapies. Though only recently discovered, biofilm has existed for millennia and complicates nearly every aspect of medicine. Biofilm impacts wound healing by allowing bacteria to evade immune responses, prolonging inflammation and disabling skin barrier function. It is important to understand why problem wounds persist despite state-of-the-art treatment, why they are difficult to accurately diagnose, and why they recur. The aim of this article is to focus on current gaps in knowledge related to problem wounds, specifically, biofilm infection.

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“…WED markedly disrupted biofilm integrity in a setting where normal silver dressing was ineffective. Biofilm thickness and number of live bacterial cells were decreased in the presence of WED because WED served a spontaneous source of reactive oxygen species [31].…”

Section: Delivery Of Silvermentioning

confidence: 99%

Delivery Systems in Wound Healing and Nanomedicine

Fu¹

2016

Wound Healing - New Insights Into Ancient Challenges

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Introduction: Delivery systems in nanomedicine contribute to the improvements in wound healing, tissue regeneration, and anticancer pharmacological fields. Although various wound dressings have been used in wound care treatments, there is a great challenge in the wound management of ulcers, trauma, chronic wounds, and severe injury and burns, especially infected wounds. Body: To accelerate wound healing, influence tissue repair, reduce scarring, and control infection, various delivery devices have been developed in wound healing. The application of delivery devices has improved early as well as long-term wound care in delayed healing wounds. Main delivery systems are described, including drugs, bioactive proteins/growth factors, genes, and cells, outlining the advantages and limitations of each carrier in wound healing, as well as the mechanisms and release. This chapter reviews biomaterials and scaffolds that provide the carriers of bioactive agents, which include antimicrobial agents, combinations of cells, growth factors and genes, both scaffolds and cell interactions toward regeneration of skin tissues, vascular reconstructions, as well as transdermal carriers. In addition, the regulations, procedures, and clinical trails for delivery systems for wound healing are discussed. Conclusion: In the past decades, many wound dressings and skin substitutes have been developed to treat skin loss and wounds. Delivery systems can improve wound healing and tissue regeneration. Looking toward the future, the need for delivery wound healing products for chronic and complex wounds will increase. Functionalized delivery systems will probably be the academic interest and industrial focus on wound healing.

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Silver-Zinc Redox-Coupled Electroceutical Wound Dressing Disrupts Bacterial Biofilm

Cited by 64 publications

References 81 publications

A Wireless Electroceutical Dressing Lowers Cost of Negative Pressure Wound Therapy

A Wireless Electroceutical Dressing Lowers Cost of Negative Pressure Wound Therapy

A Formidable Foe Is Sabotaging Your Results: What You Should Know about Biofilms and Wound Healing

Delivery Systems in Wound Healing and Nanomedicine

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