Silver sulfadiazine immobilized glass as antimicrobial fillers for dental restorative materials

Srivastava, Rohit; Sun, Yuyu

doi:10.1016/j.msec.2017.02.069

Cited by 19 publications

(20 citation statements)

References 32 publications

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“…Quaternized PEI targets the bacteria cell membrane and eliminates them via a cell lysis mechanism. Due to the positively charged ammonium groups, the polymer gets attracted toward the bacteria via electrostatic interaction . The hydrophobic alkyl groups will be further pulled into the cell as the interaction on the membrane itself will cause the disruption of the lipid bilayer.…”

Section: Introductionmentioning

confidence: 99%

Quarternized Short Polyethylenimine Shows Good Activity against Drug‐Resistant Bacteria

Yew

Chee

Zhang

et al. 2017

Macro Materials & Eng

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The rise in resistant bacteria strains worldwide is proving to be a challenge to the healthcare industry. These “superbugs” are emerging faster than the rate of new antibiotic discovery. This has a heavy impact on medical devices as they are susceptible to biofilm production. Antimicrobial resistance (AMR) causes infections to be difficult to treat, especially postimplantation of a medical device. To prevent bacterial adhesion on devices, various types are coatings are introduced. By binding antibiotics to polymers, an effective adhesive coating on the surface can be created. However, with AMR on the rise, these polymers are losing their efficacy in the application. Another class of antimicrobial polymers with a different mode of mechanism will be explored in this project. Biocidal polymers are effective antimicrobial agents as they rely on the electrostatic interactions between the polymeric charged groups and the charged microbial membrane. Polyethylenimine (PEI) can be modified to achieve a macromolecule containing various charged cationic groups. Quaternizing low‐molecular‐weight PEI with different alkyl groups of short, long, and aromatic groups will give rise to various structural differences. The structure of the quaternized PEI is characterized, and its antimicrobial activity and compatibility are shown to be remarkably improved.

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Section: Introductionmentioning

confidence: 99%

Quarternized Short Polyethylenimine Shows Good Activity against Drug‐Resistant Bacteria

Yew

Chee

Zhang

et al. 2017

Macro Materials & Eng

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“…Because of the rapid release of silver ions and possible biological toxicity, Srivastava and Sun covalently immobilized silver sulfadiazine onto glass fillers and used them in dental restorative formulas. The modified composites provided non-leachable and contact-dependent antimicrobial effects [ 102 ]. Sulfadiazine promotes the formation of a complex of silver and the DNA of bacteria [ 103 ], which ultimately leads to the death of the bacteria, showing a synergistic effect with silver.…”

Section: Current Antimicrobial Strategies Of Resin Compositesmentioning

confidence: 99%

Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Sun¹,

Zhang²,

Bai³

et al. 2021

Polymers

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Repairing tooth defects with dental resin composites is currently the most commonly used method due to their tooth-colored esthetics and photocuring properties. However, the higher than desirable failure rate and moderate service life are the biggest challenges the composites currently face. Secondary caries is one of the most common reasons leading to repair failure. Therefore, many attempts have been carried out on the development of a new generation of antimicrobial and therapeutic dental polymer composite materials to inhibit dental caries and prolong the lifespan of restorations. These new antimicrobial materials can inhibit the formation of biofilms, reduce acid production from bacteria and the occurrence of secondary caries. These results are encouraging and open the doors to future clinical studies on the therapeutic value of antimicrobial dental resin-based restoratives. However, antimicrobial resins still face challenges such as biocompatibility, drug resistance and uncontrolled release of antimicrobial agents. In the future, we should focus on the development of more efficient, durable and smart antimicrobial dental resins. This article focuses on the most recent 5 years of research, reviews the current antimicrobial strategies of composite resins, and introduces representative antimicrobial agents and their antimicrobial mechanisms.

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“…4 Bis-GMA has great properties such as high molecular weight, low volatility, and high viscosity. [5][6][7] Triethylene-glycol-dimethacrylate (TEGDMA) has been used as a diluent in the dental polymer matrix to reduce the viscosity of Bis-GMA. 8,9 Camphorquinone (CQ) has long been utilized as a light-sensitive photo-initiator in the polymerization of dental resin composite materials.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of thermo-mechanical and thermogravimetric characterization of hybrid dental restorative composite materials

Yadav

Meena

2022

Proceedings of the Institution of Mechanical Engineers, Part L:

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The purpose of the study is to create resin-based micro-nano particulates-filled dental restorative composite materials and investigate the influence of variable nano-hydroxyapatite filler concentration on their thermo-mechanical and thermogravimetric properties. Two series were created by combining silane treated nano-hydroxyapatite filler particles (wt.% of 0, 2, 4, 6, and 8) with foreign ceramic particles (alumina and titanium oxide). Each series consists of five compositions. For each dental composition, the amount of foreign ceramics (20 wt.%) remained constant. The dental composite samples were polymerized for 30 s on each side using a blue LED light. Thermo-mechanical and thermogravimetric analysis was performed at various temperatures range. At preliminary temperatures (30–40°C), the hybrid nano-hydroxyapatite-TiO2 dental composite filled with 8 wt.% nano-hydroxyapatite exhibited storage modulus (about 90 MPa) whereas nano-hydroxyapatite-Al2O3 dental composite filled with 8 wt.% nano-hydroxyapatite exhibited storage modulus (about 260 MPa). Themal stability of nano-hydroxyapatite-Al2O3 and nano-hydroxyapatite-TiO2 dental composite was 99.90% and 99.82% at 90°C, respectively. The glass phase, glass transition phase, and rubbery phase were observed at various temperatures. From the results, it revealed that Al2O3-nano-hydroxyapatite filled dental composite was observed significant than TiO2–nano-hydroxyapatite filled dental composite.

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Silver sulfadiazine immobilized glass as antimicrobial fillers for dental restorative materials

Cited by 19 publications

References 32 publications

Quarternized Short Polyethylenimine Shows Good Activity against Drug‐Resistant Bacteria

Quarternized Short Polyethylenimine Shows Good Activity against Drug‐Resistant Bacteria

Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Comparative study of thermo-mechanical and thermogravimetric characterization of hybrid dental restorative composite materials

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