Silver–palm pollen nanocomposite exhibits antiproliferative, antioxidant, and proapoptotic properties on MCF-7 breast cancer cells

Tabrizi, Masoud Homayouni; Karimi, Ehsan; Namvar, Farideh; Soltani, Mohammad Reza; Pouresmaeil, Vahid

doi:10.1007/s11164-018-3507-9

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…A higher proportion was 50 nm, and most of the particles appeared spherical, and few were polygonal in shape ( Figure 3 B). Indeed, other researchers [ 26 ] and [ 27 ] have also reported similar results regarding the shape and size of the nanoparticles from the TEM analyses. The smaller size and spherical shape exhibited by the Ca-AgNPs are generally desirable for biomedical applications such as drug delivery.…”

Section: Resultssupporting

confidence: 70%

Characterization and Therapeutic Applications of Biosynthesized Silver Nanoparticles Using Cassia auriculate Flower Extract

Sabapathi

Ramalingam

ArulJothi

et al. 2023

Plants

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The current study analyzes the biosynthesis of silver nanoparticles using the Cassia auriculate flower extract as the reducing and stabilizing agent. The Cassia auriculate- silver nanoparticles (Ca-AgNPs) obtained are characterized by UV–Vis spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) analysis. The results of the spectral characterization have revealed that the surface Plasmon resonance band observed at 448 nm confirms the formation of AgNPs. TEM analysis of the Ca-AgNPs was a predominately spherical shape with a size assortment of 30 to 80 nm and an angular size of 50 nm. The well-analyzed Ca-AgNPs were used in various biological assays, including healthcare analysis of antimicrobial, antioxidant (DPPH), and cytotoxic investigations. Ca-AgNPs showed efficient free radical scavenging activity and showed excellent antimicrobial activity against to pathogenic strains. The occurrence of Ca-AgNPs lead to reduced Live/Dead ratio of bacteria (from 36.97 ± 1.35 to 9.43 ± 0.27) but improved the accumulation of bacterial clusters. The cytotoxicity of Ca-AgNPs was carried out by MTT assay against MCF-7 breast cancer cells and a moderate cytotoxic. The approach of flower extract-mediated synthesis is a cost-efficient, eco-friendly, and easy alternative to conventional methods of silver nanoparticle synthesis.

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Section: Resultssupporting

confidence: 70%

Characterization and Therapeutic Applications of Biosynthesized Silver Nanoparticles Using Cassia auriculate Flower Extract

Sabapathi

Ramalingam

ArulJothi

et al. 2023

Plants

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“…Folate receptors are overexpressed in various types of human cancers, including breast, colon, lung, liver, ovarian, and pancreatic cancer cells [ 7 – 10 ]. In this regard, considering the limited chemical stability, non-polar structure, and weak aqueous solubility of natural-originated bioactive compounds, nanotechnology has opened novel promising horizons in cancer treatment strategies by presenting the applicable nano drug delivery systems [ 11 – 14 ]. These systems have played a crucial role in delivering hydrophobic.…”

Section: Introductionmentioning

confidence: 99%

Effects of solid lipid nanocarrier containing methyl urolithin A by coating folate-bound chitosan and evaluation of its anti-cancer activity

Al-Fatlawi,

Pouresmaeil,

Davoodi-Dehaghani

et al. 2024

BMC Biotechnol

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Background Nanotechnology-based drug delivery systems have received much attention over the past decade. In the present study, we synthesized Methyl Urolithin A-loaded solid lipid nanoparticles decorated with the folic acid-linked chitosan layer called MuSCF-NPs and investigated their effects on cancer cells. Methods MuSCF-NPs were prepared using a high-pressure homogenization method and characterized using FTIR, FESEM, DLS, and zeta potential methods. Drug encapsulation was assessed by spectrophotometry and its cytotoxic effect on various cancer cells (MDA-MB231, MCF-7, PANC, AGS, and HepG2) by the MTT method. Antioxidant activity was assessed by the ABTS and DPPH methods, followed by expression of genes involved in oxidative stress and apoptosis by qPCR and flow cytometry. Results The results showed the formation of monodisperse and stable round nanoparticles with a size of 84.8 nm. The drug loading efficiency in MuSCF-NPs was reported to be 88.6%. MuSCF-NPs exhibited selective cytotoxicity against MDA-MB231 cells (IC50 = 40 μg/mL). Molecular analysis showed a significant increase in the expression of Caspases 3, 8, and 9, indicating that apoptosis was occurring in the treated cells. Moreover, flow cytometry results showed that the treated cells were arrested in his SubG1 phase, confirming the pro-apoptotic effect of the nanoparticles. The results indicate a high antioxidant effect of the nanoparticles with IC50 values of 45 μg/mL and 1500 μg/mL against ABTS and DPPH, respectively. The reduction of catalase gene expression confirmed the pro-oxidant effect of nanoparticles in cancer cells treated at concentrations of 20 and 40 μg/mL. Conclusions Therefore, our findings suggest that the MuSCF-NPs are suitable candidates, especially for breast cancer preclinical studies.

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Anti-proliferative activity of chitosan-coated oxypeucedanin nano-chitosomes (COPD-NCs) against human HT-29 colon cancer cells: in vitro study

Almohammed,

Meshkani,

Homayouni Tabrizi

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Silver–palm pollen nanocomposite exhibits antiproliferative, antioxidant, and proapoptotic properties on MCF-7 breast cancer cells

Cited by 7 publications

References 12 publications

Characterization and Therapeutic Applications of Biosynthesized Silver Nanoparticles Using Cassia auriculate Flower Extract

Characterization and Therapeutic Applications of Biosynthesized Silver Nanoparticles Using Cassia auriculate Flower Extract

Effects of solid lipid nanocarrier containing methyl urolithin A by coating folate-bound chitosan and evaluation of its anti-cancer activity

Anti-proliferative activity of chitosan-coated oxypeucedanin nano-chitosomes (COPD-NCs) against human HT-29 colon cancer cells: in vitro study

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