Silver Nanoparticles Stimulates Spermatogenesis Impairments and Hematological Alterations in Testis and Epididymis of Male Rats

Olugbodi, Janet Olayemi; David, Oladipupo; Oketa, Ene Naomi; Lawal, Bashir; Okoli, Bamidele Joseph; Mtunzi, Fanyana M.

doi:10.3390/molecules25051063

Cited by 60 publications

(43 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A considerable decrement in the relative weight of epididymis and BW of mice receiving a high dose of SWCNT (50 mg/kg) for 35 days is an indication of induced epididymal atrophy. In line with our observations, Olugbodi et al (77) and Watanabe (78) reported reductions in the relative weight of epididymis and testes (after 7 days) and vesicular and prostate glands (after 19 days) following nanoparticle administration to rats. We found the toxic effects of high CNTs doses on body weight and epididymal weight.…”

Section: Discussionsupporting

confidence: 92%

Spermatotoxic Effects of Single-Walled and Multi-Walled Carbon Nanotubes on Male Mice

et al. 2020

View full text Add to dashboard Cite

Carbon-based nanomaterials possess a remarkably high potential for biomedical applications due to their physical properties; however, their detrimental effects on reproduction are also concerned. Several reports indicate the toxicity of carbon nanotubes (CNT); nevertheless, their impact on intracellular organelles in the male reproductive organs has not been fully elucidated. Herein, we report on the reprotoxicity of single-walled (SWCNT) and multi-walled carbon nanotubes (MWCN) on several intracellular events and histological criteria in pubertal male BALB/c mice orally treated with 0, 10, and 50 mg/kg/day doses for 5 weeks. Biomarkers of oxidative stress and mitochondrial functionality, histopathological alterations, and epididymal sperm characteristics were determined. Oral administration of CNTs at 10 and 50 mg/kg evoked a significant decrement in weight coefficient, sperm viability and motility, hypo-osmotic swelling (HOS) test, sperm count, mitochondrial dehydrogenase activity, ATP content, total antioxidant capacity, and GSH/GSSH ratio in the testis and epididymal spermatozoa. On the other hand, percent abnormal sperm, testicular and sperm TBARS contents, protein carbonylation, ROS formation, oxidized glutathione level, and sperm mitochondrial depolarization were considerably increased. Significant histopathological and stereological alterations in the testis occurred in the groups challenged with CNTs. The current findings indicated that oxidative stress and mitochondrial impairment might substantially impact CNTs-induced reproductive system injury and sperm toxicity. The results can also be used to establish environmental standards for CNT consumption by mammals, produce new chemicals for controlling the rodent populations, and develop therapeutic approaches against CNTs-associated reproductive anomalies in the males exposed daily to these nanoparticles.

show abstract

Section: Discussionsupporting

confidence: 92%

Spermatotoxic Effects of Single-Walled and Multi-Walled Carbon Nanotubes on Male Mice

et al. 2020

View full text Add to dashboard Cite

show abstract

“…OH). 70,71 However, inadequacy in antioxidant systems to scavenge ROS has been implicated in the onset of dysgonadogenesis. 7,59 In this study, we observed that the animals treated with DOX exhibited a marked (p < 0.05) diminution in the activities of antioxidant enzymes such as SOD, CAT, GPx, GST, as well as non-enzymatic antioxidants including GSH and TSH, similar to other reports.…”

Section: Discussionmentioning

confidence: 99%

Luteolin abates reproductive toxicity mediated by the oxido-inflammatory response in Doxorubicin-treated rats

Owumi

Ijadele

Arunsi

et al. 2020

Toxicology Research and Application

View full text Add to dashboard Cite

The anti-neoplastic use of Doxorubicin (DOX) is hampered by several limitations, including reproductive toxicity. Luteolin (LUT)–a phytochemical-biological benefits include antioxidative and anti-inflammatory actions. Here we examined the protective effect of LUT against DOX-induced reproductive toxicity in an in vivo model—male albino Wistar rats—randomly assigned to five groups and treated as follows: Control (corn oil 2 mL/kg; per os), LUT (100 mg/kg; per os), DOX (2 mg/kg) by intraperitoneal injections, co-treated groups received LUT (50 and 100 mg/kg) with DOX. Treatment with DOX alone, significantly (p > 0.05), reduced biomarkers of testicular function, reproductive hormone levels, testicular and epididymal antioxidant, and anti-inflammatory cytokine. DOX increased (p > 0.05) sperm morphological abnormalities, as well as reactive oxygen and nitrogen species, lipid peroxidation, xanthine oxidase, a pro-inflammatory cytokine, and apoptotic biomarkers. Furthermore, testicular and epididymal histological lesion complemented the observed biochemical changes in treated rats. LUT co-treatment resulted in a dosage-dependent improvement in rats’ survivability, antioxidants capacity, reduction in biomarkers of oxidative stress, pro-inflammatory cytokines, and apoptosis in rat’s testis and epididymis. Also, LUT treatment resulted in improved histological features in the testis and epididymis, relative to DOX alone treated rats. LUT co-treatment abated DOX-mediated reproductive organ injuries associated with pro-oxidative, inflammatory, and apoptotic mechanisms. LUT supplementation may serve as a phyto-protective agent in alleviating male reproductive organ toxic injuries associated with Doxorubicin therapy.

show abstract

“…NPs are used for dermatological treatments, for skin care and in diagnostic imaging of skin diseases [ 64 ]. Sub-dermal exposure of Ag NPs for 7 and 28 days in male rats showed alterations in sperm number and motility as well as in testosterone (T), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels along with histological abnormalities in the testis [ 65 ]. In some studies, it is reported that NPs cannot penetrate the skin, while in others penetration of metallic NPs, including iron NPs, is confirmed through hair follicles [ 66 ].…”

Section: Path Of Nps Into the Reproductive Systemmentioning

confidence: 99%

“…A very recent study demonstrated that nanosized Ag NPs caused toxic effects on the reproductive system of male rats. Reduction in body weight was indeed observed after sub-dermal exposure of Ag NPs in male rats when administered at a dose of 50 mg/kg BW for 28 days, whereas decrease in the relative weight of testes and epididymis was found with the same dose exposure for 7 days [ 65 ]. Therefore, it is evident that NPs’ impact on body and organ weight is dose and time dependent.…”

Section: Adverse Effects Of Nps On the Reproductive Systemmentioning

confidence: 99%

Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production

Iftikhar

Noureen

Uzair

et al. 2021

IJERPH

View full text Add to dashboard Cite

Advancement in the field of nanotechnology has prompted the need to elucidate the deleterious effects of nanoparticles (NPs) on reproductive health. Many studies have reported on the health safety issues related to NPs by investigating their exposure routes, deposition and toxic effects on different primary and secondary organs but few studies have focused on NPs’ deposition in reproductive organs. Noteworthy, even fewer studies have dealt with the toxic effects of NPs on reproductive indices and sperm parameters (such as sperm number, motility and morphology) by evaluating, for instance, the histopathology of seminiferous tubules and testosterone levels. To date, the research suggests that NPs can easily cross the blood testes barrier and, after accumulation in the testis, induce adverse effects on spermatogenesis. This review aims to summarize the available literature on the risks induced by NPs on the male reproductive system.

show abstract

Silver Nanoparticles Stimulates Spermatogenesis Impairments and Hematological Alterations in Testis and Epididymis of Male Rats

Cited by 60 publications

References 53 publications

Spermatotoxic Effects of Single-Walled and Multi-Walled Carbon Nanotubes on Male Mice

Spermatotoxic Effects of Single-Walled and Multi-Walled Carbon Nanotubes on Male Mice

Luteolin abates reproductive toxicity mediated by the oxido-inflammatory response in Doxorubicin-treated rats

Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production

Contact Info

Product

Resources

About