Silver Nanoparticles: Sensing and Imaging Applications

Caro, Carlos; Castillo, Paula; Klippstein, Rebecca; Pozo, David; Zaderenko, Ana Paula

doi:10.5772/8513

Cited by 69 publications

(59 citation statements)

References 106 publications

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“…SWNT is widely used as a carrier in DDS [5,35]. AgNPs can be used as a Raman tag for imaging [36]. DNA can be used to represent the therapeutic agent (for genetic disorders) as well as a targeting moiety (nucleic acid based aptamers) [11,13].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cytotoxicity, biophysics and biomechanics of cells treated with functionalized hybrid nanomaterials

Subbiah

Ramasundaram

et al. 2013

J. R. Soc. Interface.

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Hybrids consisting of carboxylated, single-walled carbon nanotube (c-SWNT)-silver nanoparticles (AgNPs)-DNA-poly vinyl alcohol (PVA) are synthesized via sequential functionalization to mimic the theragnostic (therapy and diagnosis) system. Carboxylation of SWNT has minimized the metal impurities with plenty of -COOH groups to produce hybrid (c-SWNT-AgNPs). The hybrid is further wrapped with DNA (hybrid-DNA) and encapsulated with PVA as hybrid composite (HC). Materials were tested against human alveolar epithelial cells (A549), mouse fibroblasts cells (NIH3T3) and human bone marrow stromal cells (HS-5). The composition-sensitive physico-chemical interactions, biophysics and biomechanics of materials-treated cells are evaluated. The cell viability was improved for HC, hybrid-PVA and c-SWNT when compared with SWNT and hybrid. SWNT and hybrid showed cell viability less than 60% at high dose (40 mg ml 21 ) and hybrid-PVA and HC retained 80% or more cell viability. The treatment of hybrid nanomaterials considerably changed cell morphology and intercellular interaction with respect to the composition of materials. Peculiarly, PVA-coated hybrid was found to minimize the growth of invadopodia of A549 cells, which is responsible for the proliferation of cancer cells. Surface roughness of cells increased after treatment with hybrid, where cytoplasmic regions specifically showed higher roughness. Nanoindentation results suggest that changes in biomechanics occurred owing to possible internalization of the hybrid. The changes in force spectra of treated cells indicated a possible greater interaction between the cells and hybrid with distinct stiffness and demonstrated the surface adherence and internalization of hybrid on or inside the cells.

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Section: Introductionmentioning

confidence: 99%

Evaluation of cytotoxicity, biophysics and biomechanics of cells treated with functionalized hybrid nanomaterials

Subbiah

Ramasundaram

et al. 2013

J. R. Soc. Interface.

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“…The CAS-AgNP without additional metal ions exhibited an extinction maximum at 391 nm, assignable to the dispersed CAS-AgNPs. 1,15,16 For samples containing other metal ions, a new LSPR band at around 450 to 600 nm appeared, while the extinction at 391 nm decreased. This is indicative of CAS-AgNP aggregation, which changes the LSPR properties.…”

Section: Multiple Coloration Of Cas-agnpmentioning

confidence: 99%

“…14 Silver nanoparticle (AgNP) sensors have also become popular because they can afford sharper extinction bands with higher extinction coefficients. 1,[15][16][17][18][19][20] Owing to the vase-like shape required to accommodate a guest molecule, calixarene has been used as the receptor molecule for AgNPs. [21][22][23] For example, AgNPs coated with calix [4]arene-p-tetrasulfonate (CAS) in aqueous solutions change their color from yellow to red by aggregation through bridging of the AgNPs by inclusion of a guest molecule, such as histidine 21 and isocarbophos 22 to CAS molecules on different particles.…”

Section: Introductionmentioning

confidence: 99%

Multi-coloration of Calixarene-coated Silver Nanoparticles for the Visual Discrimination of Metal Elements

Abe

Iki

2017

ANAL. SCI.

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Upon mixing with metal ions such as Cd II , Tb III , Cu II , Ni II , Pb II , Zn II , and Co II at pH 10.0, solutions of silver nanoparticles (AgNPs) coated with calix[4]arene-p-tetrasulfonate (CAS-AgNP) exhibited multi-coloration from yellow to orange, violet, and green, depending on the metal elements present, which allowed for visual discrimination of the ions. This is contrary to the AgNP sensors exhibiting a uniform color change from yellow to red upon binding of a receptor molecules at the surface of AgNPs to an analyte. The TEM images of the samples obtained from the resultant solution showed two regions. First, a region where CAS-AgNPs assembled on the surface of the metal hydroxides. The size of the hydroxide crystals varied from 50 to 200 nm with the type of metal element present, and roughly correlated with the extinction band of the aggregated AgNPs. Second, the amorphous region in which CAS-AgNPs dispersed randomly. The difference in the amount of the crystal region and the area seemed to lead to the multi-coloration.

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“…Although silver exhibits many advantages over gold, such as higher extinction coefficients, sharper extinction (LSPR) bands and extremely high field enhancements [26], AuNPs are the most extensively used NPs due to their unique tunable optical properties, low toxicity, chemical stability, biocompatibility and their amenability of synthesis and functionalization [27]. AuNPs with sizes up to a few 10s of nm show a LSPR in the visible; UV-Vis spectroscopy can therefore assist in the detection of the spectral position of the LSPR and its shift.…”

Section: Sensingmentioning

confidence: 99%

OMCVD Gold Nanoparticles Covalently Attached to Polystyrene for Biosensing Applications

Kandeepan

Paquette

Gilroy

et al. 2015

Chemical Vapor Deposition

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Silver Nanoparticles: Sensing and Imaging Applications

Cited by 69 publications

References 106 publications

Evaluation of cytotoxicity, biophysics and biomechanics of cells treated with functionalized hybrid nanomaterials

Evaluation of cytotoxicity, biophysics and biomechanics of cells treated with functionalized hybrid nanomaterials

Multi-coloration of Calixarene-coated Silver Nanoparticles for the Visual Discrimination of Metal Elements

OMCVD Gold Nanoparticles Covalently Attached to Polystyrene for Biosensing Applications

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