Silver nanoparticles penetration in dentin: Implications for long-term caries arrestment

Andrade, Maria Clara Müller de; Rosenblatt, Aronita; Galembeck, André

doi:10.1016/j.mtla.2022.101489

Cited by 4 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The slow release of Ag+ may explain the long-term carious stop effect of AgNPs observed in the current clinical trial and previous research ( 16 , 26 ). Andrade, Rosenblatt, and Galembeck ( 15 ) found that longer exposure times and smaller nanoparticle sizes increased the penetration depth of the AgNPs formulation used in this study. The total amount of silver found in intratubular dentin was estimated to be within the concentration range expected to inhibit bacterial growth while remaining low enough to avoid AgNP contact with the dental pulp.…”

Section: Discussionmentioning

confidence: 57%

“…Nano Silver Fluoride (NSF) is a novel product previously studied by our research team that contains silver nanoparticles that safely stops the progression of carious lesions and have antimicrobial properties ( 12 - 14 ). This formulation differentiates because it includes: 1) fluoride, which reduces biofilm formation/adhesion and interferes with the demineralization/remineralization dynamics of dental enamel; and 2) chitosan, which chemically interacts with silver nanoparticles and increases its adhesion and stability by forming complex proteins and metal structures on dental hard tissues ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of a high concentration of nano silver fluoride in preventing caries: A randomized controlled trial

de Lavôr,

de Abreu,

Costa

et al. 2024

J Clin Exp Dent

View full text Add to dashboard Cite

Background To investigate the effectiveness of a novel agent containing Nano Silver Fluoride 1500 (NSF 1500) and chitosan to inactivate carious lesions in children. Material and Methods The study included eighty children. While both groups had fluoride dentifrice applied to their teeth, only the experimental group received treatment with the NSF 1500-ppm solution. The first and sixth-month interval examinations were conducted by two calibrated dentists (k = 0.85). Results The NSF 1500 group had 69.2% of their teeth with arrested decay, while the control group had 24.1%. The difference was statistically significant ( p 0.001), with a preventive fraction of 59.4%. The number needed to treat (NNT) was approximately two. The NSF 1500 formulation was more effective than toothbrushing alone with fluoridated dentifrice in preventing dental caries. Conclusions The effectiveness of NSF 1500 is determined by the size and depth of the dental cavity. Its ability to arrest caries lesions was comparable to previously tested products, NSF 400 and NSF 600. Key words: Preventive dentistry, dental caries, nanoparticles.

show abstract

Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Efficacy of a high concentration of nano silver fluoride in preventing caries: A randomized controlled trial

de Lavôr,

de Abreu,

Costa

et al. 2024

J Clin Exp Dent

View full text Add to dashboard Cite

show abstract

“…(116) Additionally, the small size of silver nanoparticles allows for better penetration into the porous structure of dentinal tubules and their adhesion to the tubule walls, resulting in superior efficacy compared to the non-porous structure of enamel. (117) In order to mimic the cariogenic conditions encountered in the oral cavity and due to the predominant antimicrobial effect of Nano-silver fluoride, a dual-species microbial pH-cycling models (102) was conducted in this study. The microbial pHcycling models are more likely to be resemble the conditions in the oral cavity compared to the use of chemical pH-cycling, as they incorporate microbiological factors, such as the breakdown of dentine's organic matrix by enzymes derived from bacteria and the metabolism of sugars.…”

Section: Chapter 5 Discussion and Conclusionmentioning

confidence: 99%

The effect of nano-silver fluoride in remineralization on artificial dentine caries: an in vitro study

Punpeng

View full text Add to dashboard Cite

The aim of this in vitro study was to compare the remineralization efficiency among Nano-silver fluoride 400 ppm (NSF400), 38% Silver diamine fluoride (38% SDF) and 5% Sodium fluoride (5% NaF) on artificial dentine caries in permanent molar or premolar teeth. The teeth were sectioned to obtain 120 specimens (3 x 3 x 2 mm3). After artificial caries were created, the lesion depth (LD) was measured using Micro-computed tomography (Micro-CT) (n=15 specimens/group), and the surface microhardness (SMH) was measured using a Knoop microhardness tester (n=15 specimens/group). Subsequently, all specimens were randomly assigned to four groups: Group 1) NSF400, Group 2) 38% SDF, Group 3) 5% NaF, and Group 4) Deionized water (control group). Experimental treatments were applied. All specimens were immersed in culture media containing Streptococcus mutans and Candida albicans for 24 hours to create a biofilm and underwent a biofilm pH-cycling for 7 days. The measurements of lesion depth and surface microhardness were conducted after the treatment. The results before and after treatment were compared using the paired t-test. Then, the mean percentage change in lesion depth (%LD change) and the mean percentage of surface microhardness recovery (%SHR) among the groups were compared using One-way ANOVA with Tukey's post hoc test (p<0.05). The results showed that after treatment, Groups 1 and 2 had a significant decrease in mean LD, while Groups 1, 2, and 3 exhibited a significant increase in mean SMH compared to their pre-treatment values. The %LD change in Groups 1, 2, 3, and 4 were -7.80 ? 3.70, -12.69 ? 4.66, 1.66 ? 4.80, and 8.34 ? 3.62, respectively. Group 1 exhibited a significant decrease in %LD change compared to groups 3 and 4 (p<0.001), but it was significantly lower than group 2 (p=0.013). The %SHR of groups 1, 2, 3, and 4 were 7.86 ? 3.15, 10.49 ? 1.82, 1.60 ? 1.52, and -1.44 ? 0.79 respectively. Group 1 exhibited a significantly higher %SHR compared to groups 3 and 4 but it was lower than group 2 (p<0.001). In conclusion, the Nano-silver fluoride 5provided remineralization effects on artificial dentine caries better than 5% Sodium fluoride varnish but not as effectively as 38% Silver diamine fluoride.

show abstract

Synthesis methods and characterization parameters of silver nanoparticles

Tosun,

Özgür

2024

Silver Nanoparticles for Drug Delivery

View full text Add to dashboard Cite

Silver nanoparticles penetration in dentin: Implications for long-term caries arrestment

Cited by 4 publications

References 39 publications

Efficacy of a high concentration of nano silver fluoride in preventing caries: A randomized controlled trial

Efficacy of a high concentration of nano silver fluoride in preventing caries: A randomized controlled trial

The effect of nano-silver fluoride in remineralization on artificial dentine caries: an in vitro study

Synthesis methods and characterization parameters of silver nanoparticles

Contact Info

Product

Resources

About