Silver nanoparticles in situ synthesized by polysaccharides from Sanghuangporus sanghuang and composites with chitosan to prepare scaffolds for the regeneration of infected full-thickness skin defects

Ran, Luoxiao; Zou, Yini; Cheng, Junwen; Lu, Fei

doi:10.1016/j.ijbiomac.2018.12.052

Cited by 43 publications

(25 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding the application of chitosan and its derivatives in the administration of drugs when penetration of skin barrier is critical, our results are correlated with the experimental studies [19,20] that mentioned the importance of chitosan and its derivatives in the delivery system of transdermal drugs. For Distribution parameters, especially blood-brain barrier permeability and central nervous system permeability of chitosan and its derivatives, we obtained interesting results (Table 3).…”

Section: Resultssupporting

confidence: 71%

Bioinformatics Study Applied to the Pharmacokinetic Profile of Chitosan and its Derivatives with Biomedical Applicability

Guma¹,

Nastase²,

Motoc³

et al. 2020

Rev. Chim.

View full text Add to dashboard Cite

The N-acetyl group attached to monomeric glucosamine monomer units of chitin confers an extremely low solubility, which makes chitin difficult to process and therefore limiting its medical potential. In order to be used as a drug administration system in the body, it is important to know about the pharmacokinetic profiles of chitosan and its derivatives, more specifically about ADME-Tox profiles (absorption, distribution, metabolism, excretion, and toxicology). Through cheminformatics and bioinformatics tools, ADMET is identifying, a set of pharmacokinetic characteristics, such as absorption, distribution, metabolism, blood-brain barrier, nervous system barrier, and toxicological characteristics of chitosan and 5 of its derivatives. Our results have shown that one can try to integrate the drug delivery system into the body.

show abstract

Section: Resultssupporting

confidence: 71%

Bioinformatics Study Applied to the Pharmacokinetic Profile of Chitosan and its Derivatives with Biomedical Applicability

Guma¹,

Nastase²,

Motoc³

et al. 2020

Rev. Chim.

View full text Add to dashboard Cite

show abstract

“…Nanoparticles are mostly applied in such studies because of their wound healing-inducing activity. Sanghuangporus sanghuang polysaccharide synthesized AgNPs with chitosan, forming a porous sponge structured matrix, increased wound healing via inducing wound contraction and internal tissue regeneration in damaged skin of animals and disinfected the skin surface to inhibit the growth of Escherichia coli and Staphylococcus aureus [239]. Green AuNPs synthesized with Coleus forskohlii root extract could enhance the wound closure, suppress the inflammation and induce the re-epithelization of excision in Wistar rats [240].…”

Section: Further Biomedical Applications Of Green Synthesized Aunps Amentioning

confidence: 99%

Green Silver and Gold Nanoparticles: Biological Synthesis Approaches and Potentials for Biomedical Applications

et al. 2021

View full text Add to dashboard Cite

The nanomaterial industry generates gigantic quantities of metal-based nanomaterials for various technological and biomedical applications; however, concomitantly, it places a massive burden on the environment by utilizing toxic chemicals for the production process and leaving hazardous waste materials behind. Moreover, the employed, often unpleasant chemicals can affect the biocompatibility of the generated particles and severely restrict their application possibilities. On these grounds, green synthetic approaches have emerged, offering eco-friendly, sustainable, nature-derived alternative production methods, thus attenuating the ecological footprint of the nanomaterial industry. In the last decade, a plethora of biological materials has been tested to probe their suitability for nanomaterial synthesis. Although most of these approaches were successful, a large body of evidence indicates that the green material or entity used for the production would substantially define the physical and chemical properties and as a consequence, the biological activities of the obtained nanomaterials. The present review provides a comprehensive collection of the most recent green methodologies, surveys the major nanoparticle characterization techniques and screens the effects triggered by the obtained nanomaterials in various living systems to give an impression on the biomedical potential of green synthesized silver and gold nanoparticles.

show abstract

“…However, the instability of silver nanoparticles limits their industrial application in several cases, and most of the methods to prepare AgNPs cause environmental pollution and low production efficiency. To overcome this problem, silver nanoparticles are usually loaded onto carriers [35].…”

Section: Introductionmentioning

confidence: 99%

Hydrophilic Silver Nanoparticles Loaded into Niosomes: Physical–Chemical Characterization in View of Biological Applications

Rinaldi

Favero

Moeller³

et al. 2019

Nanomaterials

View full text Add to dashboard Cite

Silver nanoparticles (AgNPs) are widely used as antibacterial agents and anticancer drugs, but often their low stability limits their mass production and broad applications. The use of niosomes as a carrier to protect and envelop AgNPs gives a new perspective to solve these problems. In this study, AgNPs were functionalized with sodium 3-mercapto-1-propanesulfonate (3MPS) to induce hydrophilic behavior, improving loading in Tween 20 and Span 20 niosomes (NioTw20 and NioSp20, respectively). Entrapment efficiency was evaluated by UV analyses and is around 1–4%. Dimensions were investigated by means of dynamic light scattering (DLS) (<2RH> = 140 ± 4 nm and <2RH> = 251 ± 1 nm respectively for NioTw20 + AgNPs and NioSp20 + AgNPs) and were compared with those by atomic force microscopy (AFM) and small angle X ray scattering (SAXS) analyses. Stability was assessed in water up to 90 days, and both in bovine serum and human serum for up to 8 h. In order to characterize the local structure of niosomes, SAXS measurements have been performed on Tween 20 and Span 20 empty niosomes and loaded with AgNPs. The release profiles of hydrophilic probe calcein and lipophilic probe Nile Red were performed in HEPES buffer and in human serum. All these features contribute to conclude that the two systems, NioTw20 + AgNPs and NioSp20 + AgNPs, are suitable and promising in the field of biological applications.

show abstract

Silver nanoparticles in situ synthesized by polysaccharides from Sanghuangporus sanghuang and composites with chitosan to prepare scaffolds for the regeneration of infected full-thickness skin defects

Cited by 43 publications

References 56 publications

Bioinformatics Study Applied to the Pharmacokinetic Profile of Chitosan and its Derivatives with Biomedical Applicability

Bioinformatics Study Applied to the Pharmacokinetic Profile of Chitosan and its Derivatives with Biomedical Applicability

Green Silver and Gold Nanoparticles: Biological Synthesis Approaches and Potentials for Biomedical Applications

Hydrophilic Silver Nanoparticles Loaded into Niosomes: Physical–Chemical Characterization in View of Biological Applications

Contact Info

Product

Resources

About