Silver nanoparticles impair Peste des petits ruminants virus replication

Khandelwal, Nitin; Kaur, Gurpreet; Chaubey, Kundan Kumar; Singh, Pushpendra; Sharma, Shalini; Tiwari, Archana; Singh, Shoor Vir; Kumar, Naveen

doi:10.1016/j.virusres.2014.06.011

Cited by 69 publications

(44 citation statements)

References 35 publications

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“…The treatment of Vero cells with non-cytotoxic concentrations of AgNPs significantly inhibited the replication of Peste des petits ruminants virus (PPRV). The mechanisms of viral replication are due to the interaction of AgNPs with the virion surface and the virion core [ 217 ]. Tannic acid mediated the synthesis of various sizes of AgNPs capable of reducing HSV-2 infectivity both in vitro and in vivo through direct interaction, blocked virus attachment, penetration, and further spread [ 218 ].…”

Section: Biological Applications Of Agnpsmentioning

confidence: 99%

Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches

Zhang

Liu

Shen

et al. 2016

IJMS

2,321

1,246

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Recent advances in nanoscience and nanotechnology radically changed the way we diagnose, treat, and prevent various diseases in all aspects of human life. Silver nanoparticles (AgNPs) are one of the most vital and fascinating nanomaterials among several metallic nanoparticles that are involved in biomedical applications. AgNPs play an important role in nanoscience and nanotechnology, particularly in nanomedicine. Although several noble metals have been used for various purposes, AgNPs have been focused on potential applications in cancer diagnosis and therapy. In this review, we discuss the synthesis of AgNPs using physical, chemical, and biological methods. We also discuss the properties of AgNPs and methods for their characterization. More importantly, we extensively discuss the multifunctional bio-applications of AgNPs; for example, as antibacterial, antifungal, antiviral, anti-inflammatory, anti-angiogenic, and anti-cancer agents, and the mechanism of the anti-cancer activity of AgNPs. In addition, we discuss therapeutic approaches and challenges for cancer therapy using AgNPs. Finally, we conclude by discussing the future perspective of AgNPs.

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Section: Biological Applications Of Agnpsmentioning

confidence: 99%

Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches

Zhang

Liu

Shen

et al. 2016

IJMS

2,321

1,246

View full text Add to dashboard Cite

show abstract

“…Several studies have reported the potent anti-fungal activity of AgNPs against several phytopathogenic fungi (e.g., Alternaria alternate, Sclerotinia sclerotiorum, Macrophomina phaseolina, Rhizoctonia solani, Botrytis cinereal and Curvularia lunata) as well as human pathogenic fungi (e.g., Candida and Trichoderma sp) [73,74]. Likewise, AgNPs have demonstrated efficient inhibitory activities against several viruses including human immunodeficiency virus, hepatitis B virus, herpes simplex virus, human parainfluenza virus, peste des petits ruminants virus, and bean yellow mosaic virus, a plant pathogenic virus [75][76][77][78][79]. Inflammation is an early immunological response against foreign particles by tissue, and, interestingly, AgNPs have been recently recognized to play important roles as anti-inflammatory agents.…”

Section: Agnps Application and Mechanism Of Actionmentioning

confidence: 99%

Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure

Ferdous

Nemmar

2020

IJMS

655

354

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Engineered nanomaterials (ENMs) have gained huge importance in technological advancements over the past few years. Among the various ENMs, silver nanoparticles (AgNPs) have become one of the most explored nanotechnology-derived nanostructures and have been intensively investigated for their unique physicochemical properties. The widespread commercial and biomedical application of nanosilver include its use as a catalyst and an optical receptor in cosmetics, electronics and textile engineering, as a bactericidal agent, and in wound dressings, surgical instruments, and disinfectants. This, in turn, has increased the potential for interactions of AgNPs with terrestrial and aquatic environments, as well as potential exposure and toxicity to human health. In the present review, after giving an overview of ENMs, we discuss the current advances on the physiochemical properties of AgNPs with specific emphasis on biodistribution and both in vitro and in vivo toxicity following various routes of exposure. Most in vitro studies have demonstrated the size-, dose- and coating-dependent cellular uptake of AgNPs. Following NPs exposure, in vivo biodistribution studies have reported Ag accumulation and toxicity to local as well as distant organs. Though there has been an increase in the number of studies in this area, more investigations are required to understand the mechanisms of toxicity following various modes of exposure to AgNPs.

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“…The study shows that AgNPs can be used as adjuvant in rabies veterinary vaccine. AgNPs interact with the virion surface as well with the virion core Peste des petits ruminants virus and it shows that there is no significant effect on the virucidal effect, instead it exerts a blocking effect on viral entry into the target cells [ 111 ]. The antiviral activity of tannic acid modified various sizes of AgNPs was studied.…”

Section: Types Of Various Nanomaterials Used In Veterinary Medicinmentioning

confidence: 99%

Theranostics Aspects of Various Nanoparticles in Veterinary Medicine

Bai

Lin

Huang

et al. 2018

IJMS

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Nanoscience and nanotechnology shows immense interest in various areas of research and applications, including biotechnology, biomedical sciences, nanomedicine, and veterinary medicine. Studies and application of nanotechnology was explored very extensively in the human medical field and also studies undertaken in rodents extensively, still either studies or applications in veterinary medicine is not up to the level when compared to applications to human beings. The application in veterinary medicine and animal production is still relatively innovative. Recently, in the era of health care technologies, Veterinary Medicine also entered into a new phase and incredible transformations. Nanotechnology has tremendous and potential influence not only the way we live, but also on the way that we practice veterinary medicine and increase the safety of domestic animals, production, and income to the farmers through use of nanomaterials. The current status and advancements of nanotechnology is being used to enhance the animal growth promotion, and production. To achieve these, nanoparticles are used as alternative antimicrobial agents to overcome the usage alarming rate of antibiotics, detection of pathogenic bacteria, and also nanoparticles being used as drug delivery agents as new drug and vaccine candidates with improved characteristics and performance, diagnostic, therapeutic, feed additive, nutrient delivery, biocidal agents, reproductive aids, and finally to increase the quality of food using various kinds of functionalized nanoparticles, such as liposomes, polymeric nanoparticles, dendrimers, micellar nanoparticles, and metal nanoparticles. It seems that nanotechnology is ideal for veterinary applications in terms of cost and the availability of resources. The main focus of this review is describes some of the important current and future principal aspects of involvement of nanotechnology in Veterinary Medicine. However, we are not intended to cover the entire scenario of Veterinary Medicine, despite this review is to provide a glimpse at potential important targets of nanotechnology in the field of Veterinary Medicine. Considering the strong potential of the interaction between the nanotechnology and Veterinary Medicine, the aim of this review is to provide a concise description of the advances of nanotechnology in Veterinary Medicine, in terms of their potential application of various kinds of nanoparticles, secondly we discussed role of nanomaterials in animal health and production, and finally we discussed conclusion and future perspectives of nanotechnology in veterinary medicine.

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Silver nanoparticles impair Peste des petits ruminants virus replication

Cited by 69 publications

References 35 publications

Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches

Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches

Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure

Theranostics Aspects of Various Nanoparticles in Veterinary Medicine

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