Silver nanoparticles coated by green graphene quantum dots for accelerating the healing of <i>MRSA</i>-infected wounds

Zhong, Xianghua; Tong, Chunyi; Liu, Tiansheng; Li, Li; Liu, Xu; Yang, Yong; Liu, Ru‐Shi; Liu, Bin

doi:10.1039/d0bm01398f

Cited by 35 publications

(11 citation statements)

References 45 publications

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“…Pal et al 45 incorporated Ag NPs into BC by UV light irradiation and got excellent antibacterial results towards E. coli . Zhong et al 46 prepared GQDs@Ag NPs for wound healing treatment. The in vitro and in vivo results demonstrated that GQDs@Ag hybrids with superior biosafety showed a markedly enhanced effect in killing MRSA and accelerating MRSA ‐infected wound healing as compared to AgNPs alone.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial composite hydrogels of graphene quantum dots and bacterial cellulose accelerate wound healing

et al. 2022

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The increased antibiotic resistance of pathogenic bacteria requires intense research of new wound healing agents. Novel wound dressings should be designed to provide wound disinfection, good moisture, and fast epithelization. In this study, bacterial cellulose (BC) was impregnated with graphene quantum dots (GQDs) for potential use in wound healing treatment. The BC was successfully loaded with approximately 11.7 wt% of GQDs. The actual release of GQDs from new designed composite hydrogels were 13%. Novel GQDs‐BC hydrogel composites are biocompatible and showed significant inhibition towards Staphylococcus aureus and Streptococcus agalactiae and bactericidal effect towards Methicillin‐resistant Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The in vitro healing analysis showed significant migration of human fibroblasts after the GQDs‐BC hydrogels application. Furthermore, after 72 h exposure to GQDs‐BC, endothelial nitric oxide synthase, vascular endothelial growth factor A, matrix metallopeptidase 9, and Vimentin gene expression in fibroblast were significantly upregulated promoting angiogenesis. GQDs‐BC hydrogel composites showed very good wound fluid absorption and water retention, which satisfies good dressing properties. All obtained results propose new designed GQDs‐BC hydrogels as potential wound dressings.

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Section: Discussionmentioning

confidence: 99%

Antibacterial composite hydrogels of graphene quantum dots and bacterial cellulose accelerate wound healing

et al. 2022

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“…Figure 2c,d indicated that the temperature increase of OHH NPs could be precisely tuned by the concentration of OHH NPs and/or laser intensity. using the previously reported equation (Zhong et al, 2020) to measure the photothermal conversion efficiency, we found that OHH NPs possessed a relatively high photothermal conversion efficiency of 27.13% (Figure 2e). According to the constant temperature change after through five heating‐cooling cycles, it could be concluded that OHH NPs possessed the high photo‐stability (Figure 2f).…”

Section: Resultsmentioning

confidence: 58%

“…Currently, including noble metal nanomaterials, metal sulfide/oxide nanomaterials, carbon-based nanomaterials, polymer-based nanomaterials, and small molecule-based nanomaterials, they have been widely studied to induce bacterial death through their own physical properties, toxicity, and combined with photothermal therapy (PTT) Gao et al, 2021;Li et al, 2020). At the same time, we also have some outstanding contributions in antibacterial (Tong et al, 2019(Tong et al, , 2020Zhong et al, 2020) aspects of nanoparticle-based combination therapy. Among various antibacterial nanomaterials, Prussian blue (PB) nanoparticles have gained great popularity for PTT due to the eminent advantages of strong NIR radiation absorption ability, high photothermal efficiency, excellent chemical stability, splendid biocompatibility, and low cost (Liu et al, 2021;Tong et al, 2020).…”

mentioning

confidence: 99%

Ofloxacin‐loaded HMPB NPs for Klebsiella pneumoniae eradication in the surgical wound with the combination of PTT

Liu

Zhong

Tang

et al. 2022

Biotech & Bioengineering

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Klebsiella pneumoniae (K. pneumoniae) is a common bacterium whose drug-resistant can cause surgical failures and incurable infections in hospital patients. Thus, how to reverse or delay the resistance induction has become a great challenge for development antiresistant drug. Recently, the combination of nanomaterial-loaded antibiotics with photothermal therapy showed the efficient antibacteria ability under a low dosage of antibiotics. In this study, a nanocomposite of HMPB NPs with inherent photothermal therapy capability was used to eradicate K. pneumoniae after loading with Ofloxacin, an antibiotic against K. pneumoniae in vitro and in vivo. The nanocomplexes named as Ofloxacin@HMPB@HA NPs showed a higher effect against K. pneumoniae by destroying cell integrity and inducing ATP leakage with the assistance of laser irradiation, compared with sole Ofloxacin@HMPB@HA NPs or laser irradiation. Surgical wound infection assay further demonstrated the efficient killing K. pneumoniae and promoting the formation of new tissues, as well, which was reflected by the rapid healing of surgical wound. In summary, these results indicate the great potential of this combinational tactic based on Ofloxacin@HMPB@HA NPs for preventing the failure caused by K. pneumoniae infection.

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“…To facilitate the description or understanding of which components of an AdMa drive hazard, we use Ag NMs which is coated with graphene-sheets contains Quantum Dots (QDs) as an existing example of a multi-elemental AdMa used as an antibacterial material 29 (Figure 2a). These AdMa consist of stable NMs (the graphene) as well as quickly soluble (Ag NMs) and slowly soluble (QD) fractions.…”

Section: Dynamic Behaviour Of Admamentioning

confidence: 99%

“Advanced materials” and the challenges on the horizon for testing their (eco)toxicity and assessing their hazard

Monikh

Peijnenburg

Oomen

et al. 2023

Environ. Sci.: Adv.

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Silver nanoparticles coated by green graphene quantum dots for accelerating the healing of MRSA-infected wounds

Abstract: Bacterial infection, especially multidrug-resistant bacteria-induced infection, is threatening human health seriously, which has posed great challenges for clinical therapy. The overuse of conventional antibiotics has given rise to bacterial resistance...

Cited by 35 publications

References 45 publications

Antibacterial composite hydrogels of graphene quantum dots and bacterial cellulose accelerate wound healing

Antibacterial composite hydrogels of graphene quantum dots and bacterial cellulose accelerate wound healing

Ofloxacin‐loaded HMPB NPs for Klebsiella pneumoniae eradication in the surgical wound with the combination of PTT

“Advanced materials” and the challenges on the horizon for testing their (eco)toxicity and assessing their hazard

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