Silver nanoparticles associated with a polyphosphate and fluoride enhance the prevention of enamel demineralization and impact on dual-biofilm adhesion

Mendes-Gouvêa, Carla Corrêa; Danelon, Marcelle; Vieira, Ana Paula Miranda; Amaral, Jackeline Gallo do; Neto, Francisco Nunes de Souza; Gorup, Luiz Fernando; Camargo, Emerson R.; Delbem, Alberto Carlos Botazzo; Barbosa, Débora de Barros

doi:10.1016/j.jdent.2022.104245

Cited by 8 publications

(5 citation statements)

References 53 publications

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“…The actions of TMP and F in the anti-caries process have already been well established [ 10 , 33 , 34 , 35 ]. Studies have shown that TMP can be adsorbed on the enamel surface, thereby reducing demineralization because this process can hinder acid diffusion and alter the affinity between enamel and salivary proteins [ 36 , 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Pomegranate Extract Potentiates the Anti-Demineralizing, Anti-Biofilm, and Anti-Inflammatory Actions of Non-Alcoholic Mouthwash When Associated with Sodium-Fluoride Trimetaphosphate

et al. 2022

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This study investigated the anti-caries and anti-inflammatory effects of mouthwash formulations containing Punica granatum (pomegranate) peel extract (PPE), sodium-trimetaphosphate, and low concentrations of fluoride. PPE was characterized using high-performance liquid chromatography (ellagic acid and punicalagin). Total phenolics were quantified among formulations, and their stability was analyzed for 28 days. The formulation effects were evaluated as follows: (1) inorganic component concentration and reduced demineralization on bovine enamel blocks subjected to pH cycling; (2) anti-biofilm effect on dual-biofilms of Streptococcus mutans ATCC 25175 and Candida albicans ATCC 10231 treated for 1 and 10 min, respectively; and (3) cytotoxicity and production of inflammatory mediators (interleukin-6 and tumor necrosis factor-alpha). The formulation containing 3% PPE, 0.3% sodium-trimetaphosphate, and 225 ppm of fluoride resulted in a 34.5% surface hardness loss; a 13% (treated for 1 min) and 36% (treated for 10 min) biofilm reduction in S. mutans; a 26% (1 min) and 36% (10 min) biofilm reduction in C. albicans; absence of cytotoxicity; and anti-inflammatory activity confirmed by decreased interleukin-6 production in mouse macrophages. Thus, our results provide a promising prospect for the development of an alcohol-free commercial dental product with the health benefits of P. granatum that have been recognized for a millennium.

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Section: Discussionmentioning

confidence: 99%

Pomegranate Extract Potentiates the Anti-Demineralizing, Anti-Biofilm, and Anti-Inflammatory Actions of Non-Alcoholic Mouthwash When Associated with Sodium-Fluoride Trimetaphosphate

et al. 2022

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“…Researchers used to combine various chemicals including calcium glycerophosphate, sodium trimetaphosphate, or plant extract with silver nanoparticles together to exert more efficient antibacterial activity as well as inhibit the process of demineralisation. 70 , 71 , 72 …”

Section: Future Outlookmentioning

confidence: 99%

Silver Compounds for Caries Management

Xu,

Zhao,

Lung

et al. 2024

International Dental Journal

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“…Nano-silver is effective against cariogenic bacteria such as Streptococcus mutans and Lactobacillus, which are the main bacteria that promote the caries process [4]. Silver nanoparticles combined with fluoride and sodium trimetaphosphate (TMP) to form multifunctional nanocomposites have been shown to protect demineralized enamel and significantly inhibit the growth of Streptococcus pyogenes and Candida albicans biofilms [5]. The addition of bio-silver nanoparticles to adhesive systems enhances the antimicrobial effect by maintaining the bond strength of the adhesive.…”

Section: Application Of Silver Nanomaterials In Cariesmentioning

confidence: 99%

Research Progress on Silver Nanoparticles in the Prevention and Treatment of Oral Diseases

Zhao,

Liu,

Zhao

et al. 2024

IJBLS

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Silver compounds and silver nanomaterials have shown excellent antimicrobial effects on microorganisms and have been used commonly in the clinic in recent years for the prevention and treatment of a variety of oral diseases, such as caries, gingivitis, pulpitis, dentin hypersensitivity and oral cancer. Since conventional silver and silver compounds lead to tooth staining, studies have indicated that silver nanoparticles can alleviate this problem and exhibit outstanding antimicrobial effects. Nowadays, nanomedicines have become a research topic as an emerging potential anticancer therapeutic drug. These nanomedicine carriers are characterized by intelligent response to the tumor microenvironment, which can deliver the drugs precisely to the tumor site and improve the therapeutic effect. Nanomedicine can also decrease the distribution of drugs in normal tissues, reduce side effects, and improve patient tolerance to treatment. The application of environmentally responsive nanomedicine in the treatment of oral squamous carcinoma demonstrates great potential and may become a novel strategy for the treatment of cancer. Consequently, the article provides a comprehensive overview of the advances in the application of silver materials in the prevention and treatment of oral diseases, as well as describes the possibility of nano-targeted therapy as an innovative strategy for the treatment of oral squamous carcinoma, which provides a new way of thought in tumor therapy and brings new expectation for enhancing the effectiveness of cancer treatment.

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Silver nanoparticles associated with a polyphosphate and fluoride enhance the prevention of enamel demineralization and impact on dual-biofilm adhesion

Cited by 8 publications

References 53 publications

Pomegranate Extract Potentiates the Anti-Demineralizing, Anti-Biofilm, and Anti-Inflammatory Actions of Non-Alcoholic Mouthwash When Associated with Sodium-Fluoride Trimetaphosphate

Pomegranate Extract Potentiates the Anti-Demineralizing, Anti-Biofilm, and Anti-Inflammatory Actions of Non-Alcoholic Mouthwash When Associated with Sodium-Fluoride Trimetaphosphate

Silver Compounds for Caries Management

Research Progress on Silver Nanoparticles in the Prevention and Treatment of Oral Diseases

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