Silver Nanoparticles as Potential Antiviral Agents

Abstract

Virus infections pose significant global health challenges, especially in view of the fact that the emergence of resistant viral strains and the adverse side effects associated with prolonged use continue to slow down the application of effective antiviral therapies. This makes imperative the need for the development of safe and potent alternatives to conventional antiviral drugs. In the present scenario, nanoscale materials have emerged as novel antiviral agents for the possibilities offered by their unique chemical and physical properties. Silver nanoparticles have mainly been studied for their antimicrobial potential against bacteria, but have also proven to be active against several types of viruses including human imunodeficiency virus, hepatitis B virus, herpes simplex virus, respiratory syncytial virus, and monkey pox virus. The use of metal nanoparticles provides an interesting opportunity for novel antiviral therapies. Since metals may attack a broad range of targets in the virus there is a lower possibility to develop resistance as compared to conventional antivirals. The present review focuses on the development of methods for the production of silver nanoparticles and on their use as antiviral therapeutics against pathogenic viruses.

Antimicrobial effects of silver zeolite, silver zirconium phosphate silicate and silver zirconium phosphate against oral microorganisms

“…Even though the precise mechanisms of biocidal activity of silver against microorganisms is not fully understood, the proposed antimicrobial mechanisms are first that, silver ions can associate with the cell wall [16] , cell membrane [17] , and cell envelope of microorganisms [18,19] . The positive charge of a silver ion is critical for antimicrobial activity, allowing electrostatic attraction between the negative charges of the bacterial cell membrane and positively charged silver particles causing cell membrane rupturing [17,[20][21][22] .…”

Evaluation of In-vitro Anti-Inflammatory Activity of Silver Nanoparticles Synthesised using Piper Nigrum Extract

“…Nanotechnology deals with the synthesis and fabrication of materials at the nanoscale level (1-100 nm) [5]. Among the various nanoparticles available, silver nanoparticles are gaining more importance due to their diversified biological properties and potential applications.…”

Influence of Experimental Conditions on Deposition of Silver Nanoparticles Onto Surface of Graphene Oxide / Wpływ Warunków Eksperymentalnych Na Proces Osadzania Nanocząstek Srebra Na Powierzchni Tlenku Grafenu

“…The last phenomenon is one of main challenge for modern chemical synthesis. Investigations describing synthesis of such kind of materials creates opportunities for producing Ag size controlled NP's -GO based hybrid materials of interesting, unique properties, including catalytic ones [14][15][16].…”