Silver Nanoparticles (AgNP) in the Environment: a Review of Potential Risks on Human and Environmental Health

León-Silva, Sein; Fernández-Luqueño, F.; López-Valdez, Fernando

doi:10.1007/s11270-016-3022-9

Cited by 114 publications

(52 citation statements)

References 140 publications

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“…Unfortunately, with the rise in the biomedical applications of AgNP, development of adverse conditions due to repeated human exposure to AgNP is imminent either from direct contact with products containing AgNP or AgNP that has leached into the ecosystem. AgNP has been reported to cause several adverse effects such as skin irritation and discoloration, hepatotoxicity, kidney damage, DNA damage and epithelia cell damage [7] .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of silver nanoparticle encapsulation in DPPC-based liposome by different methods for enhanced cytotoxicity

Yusef¹,

Casey²

2019

International Journal of Polymeric Materials and Polymeric Biom

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Here we carried out a comparative study on two cost and time effective methods of encapsulating silver nanoparticles (AgNP) in dipalmitoyl-phosphatidyl choline (DPPC)/cholesterol-based liposome to enhance its cytotoxicity and reduce cytotoxic concentrations and evaluated the effect of this on a blood cell line (THP1 monocytes) often involved in uptake of nanoparticles during human exposure. DLS and Zeta potential analyses over a 6-months period showed the extruded Lipo-AgNP (ExLipo-AgNP) exhibited more stable characteristics when compared with the probe-sonicated Lipo-AgNP (PB-Lipo-AgNP). SEM microscopy indicated agglomeration of the PB-Lipo-AgNP which was not observed in Ex-Lipo-AgNP. Ex-Lipo-AgNP also exhibited higher temperaturedependent stability with 35.3% reduction in size from 20 C to 37 C while PB-Lipo-AgNP was less stable exhibiting 55% size reduction over same temperature range. Load release study over 24 h showed a controlled load release from Ex-Lipo-AgNP while the PB-Lipo-AgNP exhibited burst release at pH 4 and 6.5. Interestingly, it was found that Ex-Lipo-AgNP induced significantly higher toxicity on THP1 cell line after 24 h exposure compared with control unexposed cells; uncoated AgNP and PB-Lipo-AgNP exposed cells at the same concentration. Thus, for the first time, we report that liposomal encapsulation of AgNP by extrusion produces a stable nanocapsule with enhanced cytotoxicity, thus preventing overreliance on high AgNP concentration to achieve desired toxicity.

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Section: Introductionmentioning

confidence: 99%

Evaluation of silver nanoparticle encapsulation in DPPC-based liposome by different methods for enhanced cytotoxicity

Yusef¹,

Casey²

2019

International Journal of Polymeric Materials and Polymeric Biom

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“…In spite of advantages and efficacy of AgNP‐containing materials, there have been concerns about adverse effects from release of silver from production, use, and discarding of those products . The most studied adverse effects of AgNP are on human health, since AgNPs may migrate from packaging materials onto food, as observed for milk .…”

Section: Inorganic Antimicrobial Nanostructuresmentioning

confidence: 99%

“…[13] In spite of advantages and efficacy of AgNP-containing materials, there have been concerns about adverse effects from release of silver from production, use, and discarding of those products. [22] The most studied adverse effects of AgNP are on human health, since AgNPs may migrate from packaging materials onto food, as observed for milk. [23] A low-dose, long-term exposure of human bronchial epithelial cells to AgNPs may induce fibrosis and epithelial-mesenchymal transition, a process associated with cancer progression.…”

Section: Silver Nanoparticlesmentioning

confidence: 99%

Nanostructured Antimicrobials in Food Packaging—Recent Advances

Azeredo

Otoni

Corrêa

et al. 2019

Biotechnology Journal

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Active food packaging systems promote better food quality and/or stability, such as by releasing antimicrobial agents into food. Advantages of adding antimicrobials to the packaging material instead of into the bulk food include controlled diffusion, reduced antimicrobial contents, and improved cost effectiveness. Nanostructured antimicrobials are especially effective due to their high specific surface area. The present review is focused on recent advances and findings on the main nanostructured antimicrobial packaging systems for food packaging purposes. Several kinds of nanostructures, including both inorganic particles and organic structures, have been proven effective antimicrobials by different mechanisms of action and with different application scopes. Moreover, there are systems containing nanocarriers to protect antimicrobials and deliver them in a controlled fashion. On the other hand, scientific data about migration of nanostructures onto food and their toxicity are still limited, requiring special attention from researchers and regulation sectors.

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“…25 Ag NPs have strong antimicrobial effect, [26][27][28][29][30] but they were suspected to have potential risks on the environment and human health. 31,32 Moreover, the absence of covalent bonds between Ag NPs and cotton bers makes the Ag NPs easy to split form the ber surface during washing process. In this respect, various approaches have been investigated to enhance the adhesive force of Ag NPs onto cotton fabrics.…”

Section: Introductionmentioning

confidence: 99%

Excellent binding effect of l-methionine for immobilizing silver nanoparticles onto cotton fabrics to improve the antibacterial durability against washing

Zhou

Cai

et al. 2018

RSC Adv.

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Silver Nanoparticles (AgNP) in the Environment: a Review of Potential Risks on Human and Environmental Health

Cited by 114 publications

References 140 publications

Evaluation of silver nanoparticle encapsulation in DPPC-based liposome by different methods for enhanced cytotoxicity

Evaluation of silver nanoparticle encapsulation in DPPC-based liposome by different methods for enhanced cytotoxicity

Nanostructured Antimicrobials in Food Packaging—Recent Advances

Excellent binding effect of l-methionine for immobilizing silver nanoparticles onto cotton fabrics to improve the antibacterial durability against washing

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