Silver nanoparticles affect bidirectional crosstalk between mitochondria and lysosomes in hemocyte subtypes of the oyster <i>Crassostrea hongkongensis</i>

Luo, Yu; Wang, Wen‐Xiong

doi:10.1039/d3en00181d

Environ. Sci.: Nano

2023

DOI: 10.1039/d3en00181d

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Silver nanoparticles affect bidirectional crosstalk between mitochondria and lysosomes in hemocyte subtypes of the oyster Crassostrea hongkongensis

Yu Luo¹,

Wen‐Xiong Wang²

Abstract: Hemocytes are the main immune cells for defense against exogenous particles and consist of three cellular subtypes (agranulocytes, semigranulocytes, and granulocytes) with heterogenous functions in the oyster Crassostrea hongkongensis. Mitochondria...

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2024

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Mitophagy and its regulatory mechanisms in the biological effects of nanomaterials

Zhang,

Yang,

Guo

et al. 2024

J of Applied Toxicology

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Mitophagy is a selective cellular process critical for the removal of damaged mitochondria. It is essential in regulating mitochondrial number, ensuring mitochondrial functionality, and maintaining cellular equilibrium, ultimately influencing cell destiny. Numerous pathologies, such as neurodegenerative diseases, cardiovascular disorders, cancers, and various other conditions, are associated with mitochondrial dysfunctions. Thus, a detailed exploration of the regulatory mechanisms of mitophagy is pivotal for enhancing our understanding and for the discovery of novel preventive and therapeutic options for these diseases. Nanomaterials have become integral in biomedicine and various other sectors, offering advanced solutions for medical uses including biological imaging, drug delivery, and disease diagnostics and therapy. Mitophagy is vital in managing the cellular effects elicited by nanomaterials. This review provides a comprehensive analysis of the molecular mechanisms underpinning mitophagy, underscoring its significant influence on the biological responses of cells to nanomaterials. Nanoparticles can initiate mitophagy via various pathways, among which the PINK1‐Parkin pathway is critical for cellular defense against nanomaterial‐induced damage by promoting mitophagy. The role of mitophagy in biological effects was induced by nanomaterials, which are associated with alterations in Ca2+ levels, the production of reactive oxygen species, endoplasmic reticulum stress, and lysosomal damage.

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Mitophagy and its regulatory mechanisms in the biological effects of nanomaterials

Zhang,

Yang,

Guo

et al. 2024

J of Applied Toxicology

View full text Add to dashboard Cite

show abstract

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Silver nanoparticles affect bidirectional crosstalk between mitochondria and lysosomes in hemocyte subtypes of the oyster Crassostrea hongkongensis

Abstract: Hemocytes are the main immune cells for defense against exogenous particles and consist of three cellular subtypes (agranulocytes, semigranulocytes, and granulocytes) with heterogenous functions in the oyster Crassostrea hongkongensis. Mitochondria...

Cited by 1 publication

References 82 publications

Mitophagy and its regulatory mechanisms in the biological effects of nanomaterials

Mitophagy and its regulatory mechanisms in the biological effects of nanomaterials

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