Silver nanoparticles adversely affect the swimming behavior of European Whitefish (<i>Coregonus lavaretus</i>) larvae within the low µg/L range

Vogt, Roland; Hartmann, Sarah; Kunze, Jan; Jupke, Jonathan Frederik; Steinhoff, Benedikt; Schönherr, Holger; Kuhnert, Klaus-Dieter; Witte, Klaudia; Lamatsch, Dunja K.; Wanzenböck, Josef

doi:10.1080/15287394.2022.2102099

Cited by 6 publications

(3 citation statements)

References 64 publications

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“…Furthermore, varying neurobehavioral effects have been reported by Vogt et al . for various coatings and sizes of AgNPs while studying exposure of larvae to Ag + which suggests that AgNPs potentially act as a neurobehavioral disruptor 55 . Fu et al .…”

Section: Discussionmentioning

confidence: 99%

“…AgNPs shape has been studied to influence the toxicity demanding further research in the field for understanding the mechanisms playing part in making AgNPs toxic 54 . Furthermore, varying neurobehavioral effects have been reported by Vogt et al for various coatings and sizes of AgNPs while studying exposure of larvae to Ag + which suggests that AgNPs potentially act as a neurobehavioral disruptor 55 . Fu et al have reported that exposure to AgNPs impairs social behavior and learning in the subjects studied which indicates a strong neurotoxic effect 56 .…”

Section: Zoi (Mm) Of Antibiotics In Combination Withmentioning

confidence: 99%

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Antibacterial efficacy of silver nanoparticles (AgNPs) against metallo-β-lactamase and extended spectrum β-lactamase producing clinically procured isolates of Pseudomonas aeruginosa

Muddassir

Raza

Munir

et al. 2022

Sci Rep

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Resistance to carbapenems is a global threat, especially in developing countries with limited health resources. Prevalence, antibiogram, PCR detection of antibiotic resistance genes, and potency of Silver Nanoparticles (AgNPs) against multidrug-resistant (MDR) Pseudomonas aeruginosa were studied. Kirby-Bauer disc method and PCR were used to study antibiogram and drug resistance genes respectively in 255 isolates of Pseudomonas aeruginosa obtained from a tertiary care hospital. Silver nitrate (AgNO3) precursor salts were reacted with Aspergillus flavus culture filtrate to trigger the extracellular mycosynthesis of AgNPs. Mycosynthesis was first monitored regularly by visible ultraviolet spectroscopy that recorded AgNP peaks of approximately 400–470 nm. Confirmation by Transmission electron micrographs provided confirmation of AgNPs formed within a range of 5–30 nm. Individual and combined antibacterial activity of ten antibiotics and AgNPs was analyzed. Pearson correlation coefficients (r) were calculated for phenotypic and genotypic multidrug resistance. Data were evaluated using SPSS version 20. p-value < 0.05 was considered statistically significant. 61.5% were carbapenemase producers (p < 0.01). The recorded frequency of blaIMP-1, blaSHV, blaVIM, blaOXA, and blaTEM were 13%, 32%, 15%, 21%, and 43%, respectively. The reducing order of antimicrobial activity of antibiotics and AgNPs was piperacillin/tazobactam + AgNPs (31 mm), cefoxitin + AgNPs (30 mm) > amikacin + AgNPs (25 mm) > aztreonam + AgNPs (23 mm) > meropenem + AgNPs (22 mm) > imipenem + AgNPs (20 mm) > gentamycin + AgNPs (17 mm) > ciprofloxacin + AgNPs (16 mm) > cefoperazone/sulbactam + AgNPs (14 mm) ≥ ceftazidime + AgNPs (14 mm). The conjugated effect of AgNPs plus antibiotics showed a 0.15–3.51 (average of 2.09) fold-area augmentation of antimicrobial activity. AgNPs conjugated with antibiotics effectively inhibited MDR Pseudomonas aeruginosa. To the best of our understanding, this is an inaugural report from Punjab Pakistan enlisting co-expression of Metallo-β-lactamases, extended-spectrum β-lactamases, and AmpC-β-lactamase plus activity of antibiotic-AgNPs.

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Section: Discussionmentioning

confidence: 99%

Section: Zoi (Mm) Of Antibiotics In Combination Withmentioning

confidence: 99%

Antibacterial efficacy of silver nanoparticles (AgNPs) against metallo-β-lactamase and extended spectrum β-lactamase producing clinically procured isolates of Pseudomonas aeruginosa

Muddassir

Raza

Munir

et al. 2022

Sci Rep

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“…Silver nanoparticles (AgNPs) have been widely used in a variety of industries. , AgNPs can be released from industrial wastewaters and consumer products to the aquatic environment, causing development damage to aquatic organisms. , The effects of AgNPs on early organ development in the model animal zebrafish have been reported . For example, small AgNPs induced developmental abnormalities, including slow blood flow, pericardial edema, curved tails, and twisted notochords in zebrafish. , AgNPs also affected the behavior of zebrafish due to their damaged skeletons. , Thus, more attention must be paid to the health risks related to AgNPs for the development of the skeletal muscle, skeleton, and spinal cord of aquatic animals, which have an important impact on their survival and reproductive behavior.…”

Section: Introductionmentioning

confidence: 99%

Nanoscale Whole-Body Expansion Microscopy Revealed the Early Skeletal Developmental Malformation Induced by Silver Nanoparticles

Wang

2023

Environ. Sci. Technol. Lett.

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The widely used silver nanoparticles (AgNPs) can cause damage to skeletal development in aquatic organisms, which has a significant impact on their survival and reproduction. We hypothesized that the biological toxicity of AgNPs itself may be the culprit for early skeletal developmental malformation. In this study, we achieved the first nanoscale visualization of the notochord and skeletal muscle anatomy affected by exposure to AgNPs through a novel whole-body expansion microscopy technique (whole-ExM). This technique allows the whole zebrafish to be expanded equally in three dimensions by ∼4.5 times, enabling nanoscale resolution imaging without complex and expensive equipment. Our results suggested that AgNPs caused curvature deformation of the notochord as well as reduced and loosely arranged skeletal muscle. In addition, we demonstrated that the main source of Ag + was the dissolution of AgNPs in vivo. Compared with that of the released Ag + , the developmental toxicity caused by AgNPs themselves was non-negligible. This work achieved cellular-level visualization of living animals and overcame the limitations of previous macroscopic or microscopic consideration of the toxicity of AgNPs. The study provided a new perspective for assessing the toxicity of nanomaterials by using whole-ExM to achieve ultraclear nanoscale imaging of biological organs.

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Aquatic Ecotoxicity of Nanoparticles

Isibor,

Kayode-Edwards,

Oyewole

et al. 2024

Environmental Nanotoxicology

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Silver nanoparticles adversely affect the swimming behavior of European Whitefish (Coregonus lavaretus) larvae within the low µg/L range

Cited by 6 publications

References 64 publications

Antibacterial efficacy of silver nanoparticles (AgNPs) against metallo-β-lactamase and extended spectrum β-lactamase producing clinically procured isolates of Pseudomonas aeruginosa

Antibacterial efficacy of silver nanoparticles (AgNPs) against metallo-β-lactamase and extended spectrum β-lactamase producing clinically procured isolates of Pseudomonas aeruginosa

Nanoscale Whole-Body Expansion Microscopy Revealed the Early Skeletal Developmental Malformation Induced by Silver Nanoparticles

Aquatic Ecotoxicity of Nanoparticles

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