Silver-Mediated Direct sp3 C–H Bond Functionalization

Abstract

Direct sp 3 C-H bond functionalization is an efficient, straightforward, and powerful method to construct new C-X (X¼C, N, F, S) bonds from nonfunctionalized aliphatic motif of organic molecules, which has been used in late-stage modification of complex molecules. In this chapter, the recent developments of silver-mediated direct sp 3 C-H functionalizations are reviewed, categorized by C-C bond formation (C-H insertion), C-N bond formation (intramolecular and intermolecular amination/amidation), C-F bond formation, and C-S bond formation.

Combined analysis of transcriptomics and metabolomics on the cumulative effect of nano-titanium dioxide on mulberry seedlings

“…TiO 2 NPs can enter soil, water and the atmosphere through sewage treatment, soil pollution treatment, waste landfill and the use of related products (Shi et al, 2016). Due to TiO 2 NPs being difficult to degrade, they can become enriched in the environment with concentrations reaching hundreds of milligrams per kilogram (Piccinno et al, 2012;Keller and Lazareva, 2014;Wang et al, 2014;Zhou et al, 2015;Aragaw et al, 2021;Nabi et al, 2021). By posing a threat to the environment, it is an emerging environmental pollutant (Frazier et al, 2014).…”

Mechanistic Study on AgI-Catalyzed Oxidative Cross-Coupling/Cyclization between Terminal Alkynes and β-Enamino Esters under Base Conditions

“…Especially, silver-mediated radical processes have attracted much attention and have emerged as a frontier area in organic chemistry . In general, Ag I salts not only can be reduced to Ag 0 but also can be oxidized to Ag II and/or Ag III through a single-electron-transfer (SET) process . Thus, the good reactivity and high selectivity have proved silver salts as one of the most prominent types of catalysts in radical chemistry.…”

“…Thus, the good reactivity and high selectivity have proved silver salts as one of the most prominent types of catalysts in radical chemistry. This was witnessed by the large number of radical reactions described in the literature. , The known approaches to access the radical species are mostly based on the in situ-generated Ag II or Ag III species from Ag I catalyst in the presence of an extra oxidant, and both experimental and theoretical studies show that the radical mechanism generally contains a plausible Ag II /Ag I or Ag III /Ag I catalytic cycle …”