Silver ions induce oxidative stress and intracellular zinc release in human skin fibroblasts

Silver nanoparticles induced neurotoxicity through oxidative stress in rat cerebral astrocytes is distinct from the effects of silver ions

“…Interestingly, this effect was independent of silver ion release as ionic silver did not cause any effect on cellular DCFH oxidation. This finding was distinct from the common sense that silver ions could induce oxidative stress (Cortese-Krott et al, 2009), which might infer that different toxicological routes existed in different experimental models. Less intracellular ROS generation was also observed in silver ions treated nitrifying cultures when compared to AgNPs groups (Choi and Hu, 2008).…”

A metabolomic study on the responses of daphnia magna exposed to silver nitrate and coated silver nanoparticles

“…A similar metabolic response with decreased amino acid levels was also observed in Cu 2 þ -exposed earthworms Lumbricus rubellus (Bundy et al, 2008). Since Ag þ is a metal known to induce oxidative stress in organisms (Cortese-Krott et al, 2009), the decreased amino acid (arginine and lysine) levels were indicative of the impact of Ag þ exposure in D. magna. Taken into consideration all these metabolic biomarkers, we found that Ag þ exposure (0.5 and 1.0 μg/L) induced disturbance of energy metabolism and oxidative stress in D. magna.…”

Predicting the environmental impact of nanosilver

“…Additionally, Ag + is able to down-regulate the expression of Nrf2 and ␥GCL (see Section 6.1), as well as interfere with intracellular zinc homeostasis (e.g. Cortese-Krott et al, 2009). It should be noted that thiol-based redox switches are now recognized as important regulators of intracellular redox state (Groitl and Jakob, 2014), thus emphasizing the potential of Ag + to disrupt cellular functions due to its high affinity for thiol-based compounds.…”