Silver(I) nitrate adducts with bidentate 2-, 3- and 4-pyridyl phosphines. Solution 31P and [31P–109Ag] NMR studies of 1∶2 complexes and crystal structure of dimeric [{Ag(d2pype)(µ-d2pype)}2][NO3]2·2CH2Cl2 [d2pype = 1,2-bis(di-2-pyridylphosphino)ethane]

Synthesis, X-ray crystal structure and cytotoxicity of a new tetranuclear ruthenium arene complex

“…Enhancing the water solubility and tuning the compounds hydrophilic/hydrophobic balance is of great interest for the use as metallo-drug, because these features might be a means to control the biodistribution and -availability of the compound. Although examples for this concept can be found in gold phosphane complexes of the water soluble bis(dipyridylphosphino)ethane ligands [12][13][14], little is known about ruthenium arene complexes of these ligands.…”

In vitro antitumour and hepatotoxicity profiles of Au(I) and Ag(I) bidentate pyridyl phosphine complexes and relationships to cellular uptake

“…The degree of hydrophilicity depends critically on the position of the N atom on the pyridyl substituent [16]. The current study includes a series of Ag(I) analogs which have been characterised in the solid state and solution [15]. An essential consideration for biological evaluation of metal-based compounds is whether the structural integrity is maintained under the testing conditions.…”

“…[Au(d3pype) 2 ]Cl [16], and [Ag(d4pype) 2 ]NO 3 (RB2 32) and [Ag(d2pype) 2 ] 2 (NO 3 ) 2 (SMV)) [15], where dppe is 1,2-bis(diphenylphosphino)ethane and dnpype is 1,2-bis(di-n-pyridylphosphino)ethane. Their lipophilicity was determined by measuring the log k w using an HPLC method described previously [19].…”

“…1). We retained aromatic substituents, which appear to be important for antitumour activity [12], but replaced some, or all by hydrophilic pyridyl groups [13][14][15][16]. As a result, a series of 1:2 adducts of Au(I) and Ag(I) with bidentate pyridylphosphines compounds were prepared with potential for activity in cisplatin-resistant ovarian cancer and reduced hepatotoxicity relative to [Au(dppe) 2 ]Cl [17].…”

Novel multitopic diphos-type ligands.

“…[5,6] To circumvent the lipophilicity related side effects, more hydrophilic diphos complexes have to be developed and one approach is to replace the phenyl rings of dppe by pyridine. [7][8][9][10][11] We have developed imidazole-based water-soluble phosphane ligands for application as enzyme models and for biomedical applications in the past. [12,13] Based upon our previous findings, we herein report on synthetic routes towards diverse imidazolyl as well as thiazolyl substituted diphosphane ligands, which should exhibit similar properties concerning their use in biological media.…”