Silver(I) Imidazolate

Rae, Duncan R.; Belmont, Philippe

doi:10.1002/047084289x.rs020.pub2

Cited by 1 publication

(1 citation statement)

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“…The presence of an additional product in a very high concentration prompted us to abandon this method. Other methods of addition using heavy metals as catalysts are also known [ 38 ]. Unfortunately, the residue of those metals in the tested sample could adversely affect the survival of cells and the results of biological tests, so we decided to give up these methods as well.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Preliminary Anticancer Activity Assessment of N-Glycosides of 2-Amino-1,3,4-thiadiazoles

et al. 2021

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The addition of 2-amino-1,3,4-thiadiazole derivatives with parallel iodination of differently protected glycals has been achieved using a double molar excess of molecular iodine under mild conditions. The corresponding thiadiazole derivatives of N-glycosides were obtained in good yields and anomeric selectivity. The usage of iodine as a catalyst makes this method easy, inexpensive, and successfully useable in reactions with sugars. Thiadiazole derivatives were tested in a panel of three tumor cell lines, MCF-7, HCT116, and HeLa. These compounds initiated biological response in investigated tumor models in a different rate. The MCF-7 is resistant to the tested compounds, and the cytometry assay indicated low increase in cell numbers in the sub- G1 phase. The most sensitive are HCT-116 and HeLa cells. The thiadiazole derivatives have a pro-apoptotic effect on HCT-116 cells. In the case of the HeLa cells, an increase in the number of cells in the sub-G1- phase and the induction of apoptosis was observed.

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Section: Resultsmentioning

confidence: 99%