Silver(I) Bromide Phosphines Induce Mitochondrial-Mediated Apoptosis in Malignant Human Colorectal Cells

Roberts, Kim Elli; Engelbrecht, Zelinda; Potgieter, Kariska; Meijboom, Reinout; Cronjé, Marianne Jacqueline

doi:10.3390/biomedicines11102794

Cited by 1 publication

(1 citation statement)

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“…The first one has a greater inhibitory effect, significantly targets mitochondria and is selective towards HT-29 cells. It may be considered as a metal-based drug candidate that could be effective against colorectal cancer [100]. The research on silver-amino acid complexes is also important.…”

Section: Silver (I) Complexesmentioning

confidence: 99%

Silver, Its Salts and Application in Medicine and Pharmacy

Żyro,

Sikora,

Szynkowska-Jóźwik

et al. 2023

IJMS

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The healing properties of silver have been used since ancient times. The main aim of the study was to collect and review the literature on the clinical potential of silver, its salts and complex compounds. The second goal was to present an outline of the historical use of silver in medicine and pharmacy, taking into account the possibility of producing pharmaceutical drug forms on the premises of pharmacies. In the context of the growing resistance of microorganisms to available, widely used antibiotics, silver plays a key role. There is only one known case of bacterial resistance to silver—the Pseudomonas stutzeri strain, which naturally occurs in silver mines. The development of research in the field of coordination chemistry offers great opportunities in the design of new substances in which silver ions can be incorporated. These substances exhibit increased potency and often an extended antimicrobial spectrum. Silver-based compounds are, however, only limited to external applications, as opposed to their historic oral administration. Advanced studies of their physicochemical, microbiological, cytotoxic and genotoxic properties are ongoing and full of challenges. The improvement of the methods of synthesis gives the possibility of applying the newly synthesized compounds ex tempore, as was the case with the complex of metronidazole with silver (I) nitrate. Some of these experimental efforts performed in vitro are followed with clinical trials. The third and final goal of this study was to present the possibility of obtaining an ointment under the conditions of an actual pharmacy using silver (I) salts and a ligand, both of which are active substances with antimicrobial properties.

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Section: Silver (I) Complexesmentioning

confidence: 99%