Silver hydroxyapatite (AgHAP) reinforced nanocomposites of poly (methyl methacrylate)-poly (ɛ-caprolactone) as hybrid orthopedic materials

Choubey, Rashmi; Chouhan, Raje; Bajpai, Anjali; Bajpai, Jaya; Singh, Sunil Kumar

doi:10.1080/00914037.2020.1765353

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…These results were proven previously by Choubey et al, 47 who demonstrated the addition of high ratio of hydrophobic PCL to PMMA (2:1) which showed an increase in hemolysis (4.7%), compared to low ratios (1:1) and (1:2) which revealed decreasing in hemolysis to (2.3 and 2.6%), respectively. 47 …”

Section: Resultssupporting

confidence: 86%

“…These results might be attributed to the hydrophobic nature of PCL, PMMA and 6-MP which significantly favors protein-surface interaction 6948 therefore enhanced thrombogenicity. These results were proven previously by Choubey et al, 47 who demonstrated the addition of high ratio of hydrophobic PCL to PMMA (2:1) which showed an increase in hemolysis (4.7%), compared to low ratios (1:1) and (1:2) which revealed decreasing in hemolysis to (2.3 and 2.6%), respectively. 47…”

Section: Candida Tropicalis S S Rsupporting

confidence: 86%

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Mercaptopurine-Loaded Sandwiched Tri-Layered Composed of Electrospun Polycaprolactone/Poly(Methyl Methacrylate) Nanofibrous Scaffolds as Anticancer Carrier with Antimicrobial and Antibiotic Features: Sandwich Configuration Nanofibers, Release Study and in vitro Bioevaluation Tests

Salim¹,

Kamoun²,

Evans³

et al. 2021

IJN

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Background: 6-Mercaptopurine (6-MP) is a potential anti-cancer agent which its therapeutic and limitation applicability due to its high toxicity. Objective: Herein, 6-MP was loaded into tri-layered sandwich nanofibrous scaffold (the top layer composed of poly methyl methacrylate/polycaprolactone (PMMA/PCL), the middle layer was PCL/PMMA/6-MP, and the bottom layer was PCL/PMMA to improve its bioactivity, adjusting the release-sustainability and reduce its toxicity. Methods: Electrospun tri-layered nanofibers composed of PCL/PMMA were utilized as nano-mats for controlling sustained drug release. Four groups of sandwich scaffold configurations were investigated with alteration of (PMMA: PCL) composition. Results:The sandwich scaffold composed of 2%PCL/4%PMMA/1%6-MP showed the best miscibility, good homogeneity and produced the smoothest nanofibers and low crystallinity. All fabricated 6-MP-loaded-PCL/PMMA scaffolds exhibited antimicrobial properties on the bacterial and fungal organisms, where the cytotoxicity evaluation proved the safety of scaffolds on normal cells, even at high concentration. Scaffolds provided a sustained-drug release profile that was strongly dependent on (PCL: PMMA). As (PCL: PMMA) decreased, the sustained 6-MP release from PCL/PMMA scaffolds increased. Results established that ~18% and 20% of 6-MP were released after 23h from (4%PCL/4%PMMA/1%6-MP) and (2%PCL/4%PMMA/1%6-MP), respectively, where this release was maintained for more than 20 days. The anti-cancer activity of all fabricated scaffolds was also investigated using different cancerous cell lines (e.g., Caco-2, MDA, and HepG-2) results showed that 6-MP-loaded-nanofibrous mats have an anti-cancer effect, with a high selective index for breast cancer. We observed that viability of a cancer cell was dropped to about 10%, using nanofibers containing 2% PCL/4%PMMA/1%6-MP. Conclusion: Overall, the PCL: PMMA ratio and sandwich configuration imparts a tight control on long-term release profile and initial burst of 6-MP for anticancer treatment purposes.

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Section: Resultssupporting

confidence: 86%

Section: Candida Tropicalis S S Rsupporting

confidence: 86%

Mercaptopurine-Loaded Sandwiched Tri-Layered Composed of Electrospun Polycaprolactone/Poly(Methyl Methacrylate) Nanofibrous Scaffolds as Anticancer Carrier with Antimicrobial and Antibiotic Features: Sandwich Configuration Nanofibers, Release Study and in vitro Bioevaluation Tests

Salim¹,

Kamoun²,

Evans³

et al. 2021

IJN

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Synthesis and characterization of poly (methyl methacrylate)/ silver-doped hydroxyapatite dip coating on Ti6Al4V

Bansal,

Gautam,

Misra

et al. 2024

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Tribological behavior of silver-doped eggshell-derived hydroxyapatite reinforcement in PMMA-based composite

Bansal,

Gautam,

Misra

et al. 2024

Proceedings of the Institution of Mechanical Engineers, Part L:

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Polymethylmethacrylate (PMMA) and hydroxyapatite (HAp) are the two most promising biocompatible materials used in biomedical applications. The current research performs the wettability and tribological characterization of the novel hybrid biocomposite of PMMA reinforced with eggshell-derived, silver-doped hydroxyapatite (HAPAg). Varying wt% of HAPAg in PMMA were analyzed using a ball-on-disk tribometer. The coefficient of friction shows an increasing trend with an increase in normal load for all the compositions while, with reinforcement of HAPAg, it increases till 5 wt% and then shows a sudden decrement at PHA7.5 due to the formation of flattened asperities at the contact surface. However, the progressive increase in hardness with the inclusion of HAPAg in PMMA correlates with the reduction in the wear rate of the composite samples. The highest wear rate was observed for PHA0 (i.e. 862.42 × 10−5 mm3/m) at 60 N. As observed, the hydrophilicity increases (contact angle changed from 96.30° ± 2.11° [PHA0] to 81.70° ± 1.01° [PHA7.5]), and the porosity decreases (≈2.86%) with the reinforcement of HAPAg in PMMA which further improves the cohesion strength and microhardness of the composite material. The X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy analysis confirms the uniform reinforcement of HAPAg, and the worn surface behavior was inspected using scanning electron microscopy, Stereo zoom microscope, and three-dimensional surface profilometer. The low-specific wear characteristic at higher loads ensures the application of developed biocomposite material in dental and orthopedic applications.

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Silver hydroxyapatite (AgHAP) reinforced nanocomposites of poly (methyl methacrylate)-poly (ɛ-caprolactone) as hybrid orthopedic materials

Cited by 4 publications

References 39 publications

Mercaptopurine-Loaded Sandwiched Tri-Layered Composed of Electrospun Polycaprolactone/Poly(Methyl Methacrylate) Nanofibrous Scaffolds as Anticancer Carrier with Antimicrobial and Antibiotic Features: Sandwich Configuration Nanofibers, Release Study and in vitro Bioevaluation Tests

Mercaptopurine-Loaded Sandwiched Tri-Layered Composed of Electrospun Polycaprolactone/Poly(Methyl Methacrylate) Nanofibrous Scaffolds as Anticancer Carrier with Antimicrobial and Antibiotic Features: Sandwich Configuration Nanofibers, Release Study and in vitro Bioevaluation Tests

Synthesis and characterization of poly (methyl methacrylate)/ silver-doped hydroxyapatite dip coating on Ti6Al4V

Tribological behavior of silver-doped eggshell-derived hydroxyapatite reinforcement in PMMA-based composite

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