Silver diamine fluoride therapy for dental care

Zheng, Faith Miaomiao; Yan, Iliana Gehui; Duangthip, Duangporn; Gao, Sherry Shiqian; Lo, Edward Chin Man; Chu, Chun Hung

doi:10.1016/j.jdsr.2022.08.001

Cited by 26 publications

(27 citation statements)

References 101 publications

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“…Some points deserve attention when comparing our study with previous ones: type of dental tissue, presence of saliva, and interference of whitening in the mineral uptake effect of SDF. Rafiee et al [16] studied enamel instead of dentin, which may overestimate the whitening potential of H 2 O 2 , since darkening by SDF is greater in active carious lesions in dentin than in the enamel [1]. Rafiee et al [16] evaluated the impact of the application of carbamide peroxide (10%) with or without potassium iodide (KI) to remove SDF stains on deciduous tooth enamel and found that there was no difference in the groups in color quality (all appeared lighter).…”

Section: Discussionmentioning

confidence: 99%

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Effect of Three Chemical Agents on Stain Removal from Dentin Caries Lesions Treated with Silver Diamine Fluoride

Rodrigues Vieira,

Costa Cruz,

Maia Silvaa

et al. 2023

Caries Res

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Introduction: this in vitro study aimed to evaluate the effect of three different chemical agents on stain removal and mineral uptake of artificial dentin caries (ADC) lesions treated with silver diamine fluoride (SDF). Methods: baseline L*a*b* values were determined in polished human permanent dentin blocks, and ADC lesions were induced with an acid gel for 1 week. Samples were assigned to four groups: three groups where half of each sample received SDF (30% SDF for 3 min), while the other half received SDF followed by a bleaching treatment protocol (garlic extract, bentonite, or 35% hydrogen peroxide). The fourth group had one SDF-treated half and one half without SDF. Colour changes (ΔE) were measured by spectrometry, and transversal microradiography was used to quantify integrated mineral loss (ΔZ) 24h after treatment (SDF or SDF+bleaching). A two-way mixed ANOVA was applied. 30% Results: SDF application increased mineral uptake by ADC (p =0.001). The type of chemical agent evaluated (p<0.0001), time (p=0.01) and their interaction (p<0.0001) bleached the ADC treated with SDF. However, 35% hydrogen peroxide was the only compound with a bleaching effect (p < 0.001), without returning to baseline colour. None of the compounds altered the mineral uptake effect of SDF (p = 0.30). Conclusion: this in vitro study showed mineral uptake effect in ACD within 24h after SDF application and the ability of hydrogen peroxide to partially remove (reduction of 24%) the staining caused by SDF without affecting its mineral uptake effect.

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Section: Discussionmentioning

confidence: 99%

“…Silver diamine fluoride (SDF) (Ag [NH 3 ] 2 F) is among the noninvasive approaches available for managing untreated caries [1]. SDF is a basic solution (pH of [10][11][12] containing silver, fluoride, and ammonia.…”

Section: Introductionmentioning

confidence: 99%

Effect of Three Chemical Agents on Stain Removal from Dentin Caries Lesions Treated with Silver Diamine Fluoride

Rodrigues Vieira,

Costa Cruz,

Maia Silvaa

et al. 2023

Caries Res

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“…SDF was invented in the 1960s in Japan [ 47 ]. It is a fluoride-based material containing silver, fluoride and ammonia, with a pH value between 9 and 10.…”

Section: Fluoride-based Materialsmentioning

confidence: 99%

“…In addition, 38% SDF acts more quickly to arrest caries than 5% fluoride varnish does [ 52 ] and arrests root caries effectively [ 53 ]. SDF’s advantages are that it is easy to operate, non-invasive, painless, non-aerosol-generating and inexpensive [ 47 ].…”

Section: Fluoride-based Materialsmentioning

confidence: 99%

Bioactive Materials for Caries Management: A Literature Review

et al. 2023

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Researchers have developed novel bioactive materials for caries management. Many clinicians also favour these materials, which fit their contemporary practice philosophy of using the medical model of caries management and minimally invasive dentistry. Although there is no consensus on the definition of bioactive materials, bioactive materials in cariology are generally considered to be those that can form hydroxyapatite crystals on the tooth surface. Common bioactive materials include fluoride-based materials, calcium- and phosphate-based materials, graphene-based materials, metal and metal-oxide nanomaterials and peptide-based materials. Silver diamine fluoride (SDF) is a fluoride-based material containing silver; silver is antibacterial and fluoride promotes remineralisation. Casein phosphopeptide-amorphous calcium phosphate is a calcium- and phosphate-based material that can be added to toothpaste and chewing gum for caries prevention. Researchers use graphene-based materials and metal or metal-oxide nanomaterials as anticaries agents. Graphene-based materials, such as graphene oxide-silver, have antibacterial and mineralising properties. Metal and metal-oxide nanomaterials, such as silver and copper oxide, are antimicrobial. Incorporating mineralising materials could introduce remineralising properties to metallic nanoparticles. Researchers have also developed antimicrobial peptides with mineralising properties for caries prevention. The purpose of this literature review is to provide an overview of current bioactive materials for caries management.

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“…However, the antibacterial potential of phytochemicals is limited [ 18 ]. An ideal anti-caries agent, silver diamine fluoride, has been demonstrated to effectively prevent and arrest dental caries [ 19 ]. The major disadvantage of silver diamine fluoride is dental staining.…”

Section: Introductionmentioning

confidence: 99%

Growing Global Research Interest in Antimicrobial Peptides for Caries Management: A Bibliometric Analysis

Zhang

Niu

Yin

et al. 2022

JFB

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Objective: Researchers are studying the use of antimicrobial peptides as functional biomaterials to prevent and treat dental caries. This study aims to investigate the global research interest in antimicrobial peptides for caries management. Methods: Two independent investigators systematically searched with keywords (‘Caries’ OR ‘Dental caries’) AND (‘Antimicrobial peptide’ OR ‘AMP’ OR ‘Statherin’ OR ‘Histatin’ OR ‘Defensin’ OR ‘Cathelicidin’) on Web of Science, PubMed and Scopus. They removed duplicate publications and screened the titles and abstracts to identify relevant publications. The included publications were summarized and classified as laboratory studies, clinical trials or reviews. The citation count and citation density of the three publication types were compared using a one-way analysis of variance. The publications’ bibliometric data were analyzed using the Bibliometrix program. Results: This study included 163 publications with 115 laboratory studies (71%), 29 clinical trials (18%) and 19 reviews (11%). The number of publications per year have increased steadily since 2002. The citation densities (mean ± SD) of laboratory study publications (3.67 ± 2.73) and clinical trial publications (2.63 ± 1.85) were less than that of review articles (5.79 ± 1.27) (p = 0.002). The three publication types had no significant difference in citation count (p = 0.54). Most publications (79%, 129/163) reported the development of a novel antimicrobial peptide. China (52/163, 32%) and the US (29/163, 18%) contributed to 50% (81/163) of the publications. Conclusion: This bibliometric analysis identified an increasing trend in global interest in antimicrobial peptides for caries management since 2002. The main research topic was the development of novel antimicrobial peptides. Most publications were laboratory studies, as were the three publications with the highest citation counts. Laboratory studies had high citation counts, whereas reviews had high citation density.

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Silver diamine fluoride therapy for dental care

Cited by 26 publications

References 101 publications

Effect of Three Chemical Agents on Stain Removal from Dentin Caries Lesions Treated with Silver Diamine Fluoride

Effect of Three Chemical Agents on Stain Removal from Dentin Caries Lesions Treated with Silver Diamine Fluoride

Bioactive Materials for Caries Management: A Literature Review

Growing Global Research Interest in Antimicrobial Peptides for Caries Management: A Bibliometric Analysis

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