Silver, copper and copper oxide nanoparticles in the fight against human viruses: progress and perspectives

Tortella, Gonzalo; Pieretti, Joana C.; Rubilar, Olga; Fernández‐Baldo, Martín A.; Benavides-Mendoza, Adalberto; Díez, M.C.; Seabra, Amedea B.

doi:10.1080/07388551.2021.1939260

Cited by 44 publications

(34 citation statements)

References 167 publications

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“…The bio-AgNPs have been mainly evaluated for their antimicrobial potential against bacteria and fungi. However, their potential against several types of viruses, including human immunodeficiency virus (HIV), hepatitis B virus (HBV), herpes simplex virus (HSV), respiratory syncytial virus (RSV), and monkey pox virus has also been realized [164][165][166]. The antiviral activity of bio-AgNPs synthesized from marine actinomycete Nocardiopsis alba was evaluated on embryonated chicken eggs infected with Newcastle viral disease (NDV), which causes acute respiratory disease and depression.…”

Section: Antiviral Activitymentioning

confidence: 99%

Biogenic Silver Nanoparticles: What We Know and What Do We Need to Know?

et al. 2021

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Nanobiotechnology is considered to be one of the fastest emerging fields. It is still a relatively new and exciting area of research with considerable potential for development. Among the inorganic nanomaterials, biogenically synthesized silver nanoparticles (bio-AgNPs) have been frequently used due to their unique physicochemical properties that result not only from their shape and size but also from surface coatings of natural origin. These properties determine antibacterial, antifungal, antiprotozoal, anticancer, anti-inflammatory, and many more activities of bio-AgNPs. This review provides the current state of knowledge on the methods and mechanisms of biogenic synthesis of silver nanoparticles as well as their potential applications in different fields such as medicine, food, agriculture, and industries.

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Section: Antiviral Activitymentioning

confidence: 99%

Biogenic Silver Nanoparticles: What We Know and What Do We Need to Know?

et al. 2021

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“…We biosynthesized AgNPs using the natural extract of B. tomentosa Linn. We then applied various biophysical and biochemical methods to characterize the potential biomedical applications of the AgNPs [ 8 , 9 , 10 , 12 , 13 , 14 , 15 , 16 , 86 ] and validated their antimicrobial and antioxidant properties [ 87 , 88 ]. We also evaluated a possible mechanism of action via molecular docking analysis.…”

Section: Discussionmentioning

confidence: 99%

“…Over the past 10 to 20 years, metal nanoparticles, and AgNPs in particular, have attracted attention due to their versatility and broad range of industrial and biomedical applications [ 8 , 9 , 10 , 11 ]. Potential uses include antimicrobial (antibacterial, antifungal, and antiviral) agents [ 12 , 13 , 14 , 15 , 16 , 17 ], biomedical device coatings, drug-delivery carriers, and imaging probes for diagnostic and optoelectronic applications [ 18 , 19 , 20 , 21 , 22 ]. AgNPs could mediate the antimicrobial activity by producing reactive oxygen species and free radicals causing cell wall damage, lipid peroxidation, protein denaturation, and nucleic acid and proton pump damage [ 4 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial, Antifungal, and Antioxidant Activities of Silver Nanoparticles Biosynthesized from Bauhinia tomentosa Linn

Senthil¹,

Subramaniyan²,

Karunanithi³

et al. 2021

Antioxidants

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The biogenic synthesis of silver nanoparticles (AgNPs) has a wide range of applications in the pharmaceutical industry. Here, we synthesized AgNPs using the aqueous flower extract of Bauhinia tomentosa Linn. Formation of AgNPs was observed using ultraviolet-visible light spectrophotometry at different time intervals. Maximum absorption was observed after 4 h at 420 nm due to the reduction of Ag+ to Ag0. The stabilizing activity of functional groups was identified by Fourier-transform infrared spectroscopy. Size and surface morphology were also analyzed using scanning electron microscopy. The present study revealed the AgNPs were spherical in form with a diameter of 32 nm. The face-centered cubic structure of AgNPs was indexed using X-ray powder diffraction with peaks at 2θ = 37°, 49°, 63°, and 76° (corresponding to the planes of silver 111, 200, 220, 311), respectively. Energy-dispersive X-ray spectroscopy revealed that pure reduced silver (Ag0) was the major constituent (59.08%). Antimicrobial analyses showed that the biosynthesized AgNPs possess increased antibacterial activity (against Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative), with larger zone formation against S. aureus (9.25 mm) compared with that of E. coli (6.75 mm)) and antifungal activity (against Aspergillus flavus and Candida albican (with superior inhibition against A. flavus (zone of inhibition: 7 mm) compared with C. albicans (zone of inhibition: 5.75 mm)). Inhibition of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity was found to be dose-dependent with half-maximal inhibitory concentration (IC50) values of 56.77 μg/mL and 43.03 μg/mL for AgNPs and ascorbic acid (control), respectively, thus confirming that silver nanoparticles have greater antioxidant activity than ascorbic acid. Molecular docking was used to determine the mode of antimicrobial interaction of our biosynthesized B. tomentosa Linn flower-powder extract-derived AgNPs. The biogenic AgNPs preferred hydrophobic contacts to inhibit bacterial and fungal sustainability with reducing antioxidant properties, suggesting that biogenic AgNPs can serve as effective medicinal agents.

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“…166 Copper nanoparticles, or copper oxide nanoparticles, have important applications as biocides, as well as antiviral action against different viruses. 167 Copper, similar to silver, has been universally recognized as a potent antimicrobial for a few millennia and is known to be applied for different applications in antiquity against infections in both animals and humans. 168 Copper nanoparticles have antiviral actions that are related to the inhibition of the mechanisms of entry, attachment or viral replication.…”

Section: The Potential Use Of Carbon Nanotubes and Metallic Nanoparti...mentioning

confidence: 99%

“…This antiviral activity occurs by the degradation of viral proteins due to the generation of hydroxyl radicals and copper ions. 167 Due to its antiviral and antimicrobial properties, copper is a potent antiviral agent that may be useful in this SARS-CoV-2 pandemic and prospectively be useful in future pandemics. 146 Copper is a good candidate in the fight against viral infections and can be useful in public spaces and common touch sites/surfaces, which can decrease the transmission rate in common places with much public access.…”

Section: The Potential Use Of Carbon Nanotubes and Metallic Nanoparti...mentioning

confidence: 99%

Coronavirus and Carbon Nanotubes: Seeking Immunological Relationships to Discover Immunotherapeutic Possibilities

Lima¹,

Octaviano²,

Piqueira³

et al. 2022

IJN

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Since December 2019, the world has faced an unprecedented pandemic crisis due to a new coronavirus disease, coronavirus disease-2019 (COVID-19), which has instigated intensive studies on prevention and treatment possibilities. Here, we investigate the relationships between the immune activation induced by three coronaviruses associated with recent outbreaks, with special attention to SARS-CoV-2, the causative agent of COVID-19, and the immune activation induced by carbon nanotubes (CNTs) to understand the points of convergence in immune induction and modulation. Evidence suggests that CNTs are among the most promising materials for use as immunotherapeutic agents. Therefore, this investigation explores new possibilities of effective immunotherapies for COVID-19. This study aimed to raise interest and knowledge about the use of CNTs as immunotherapeutic agents in coronavirus treatment. Thus, we summarize the most important immunological aspects of various coronavirus infections and describe key advances and challenges in using CNTs as immunotherapeutic agents against viral infections and the activation of the immune response induced by CNTs, which can shed light on the immunotherapeutic possibilities of CNTs.

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Silver, copper and copper oxide nanoparticles in the fight against human viruses: progress and perspectives

Cited by 44 publications

References 167 publications

Biogenic Silver Nanoparticles: What We Know and What Do We Need to Know?

Biogenic Silver Nanoparticles: What We Know and What Do We Need to Know?

Antibacterial, Antifungal, and Antioxidant Activities of Silver Nanoparticles Biosynthesized from Bauhinia tomentosa Linn

Coronavirus and Carbon Nanotubes: Seeking Immunological Relationships to Discover Immunotherapeutic Possibilities

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