Silver/chitosan nanocomposites induce physiological and histological changes in freshwater bivalve

Mohamed, Ayman Saber; Dajem, Saad Bin; Alkahtani, Mohammed Ali; Ali, Sara E.; Ibrahim, Essam H.; Morsy, Kareem; Fahmy, Sohair R.

doi:10.1016/j.jtemb.2021.126719

Cited by 7 publications

(5 citation statements)

References 49 publications

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“…For example, the gills of C. aegyptiaca are more susceptible to oxidative stress induced by AgNPs than the hepatopancreas. 145 …”

Section: Toxicity Of Mnps To Freshwater Invertebratesmentioning

confidence: 99%

“…For example, the gills of C. aegyptiaca are more susceptible to oxidative stress induced by AgNPs than the hepatopancreas. 145 The immune system of bivalves is a sensitive target of MNP toxicity. Hemocytes are the most investigated cell type among the analyzed species (Table 1).…”

Section: Bivalvia Molluscsmentioning

confidence: 99%

“…143,144 The MNPs may release extracellular metal ions, which penetrate the cell and induce oxidative stress by free radicals or ROS production and/or metallothionein (MT) induction. The oxidative stress induced by MNPs mainly includes the disruption of the antioxidant defense system (SOD, CAT, GPx, GST), 24,37,[145][146][147][148] LPO, [149][150][151][152] increased protein modification (e.g., ubiquitination), 150 and DNA damage (DNA strand breaks). 150,152,153 Oxidative damage induced by MNPs in bivalves depends on the size, composition, concentration, and exposure time (Table 1).…”

Section: Bivalvia Molluscsmentioning

confidence: 99%

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Emerging investigator series: metal nanoparticles in freshwater: transformation, bioavailability and effects on invertebrates

Wang

Liu

2022

Environ. Sci.: Nano

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“…For example, the gills of C. aegyptiaca are more susceptible to oxidative stress induced by AgNPs than the hepatopancreas. 145 …”

Section: Toxicity Of Mnps To Freshwater Invertebratesmentioning

confidence: 99%

Section: Bivalvia Molluscsmentioning

confidence: 99%

Section: Bivalvia Molluscsmentioning

confidence: 99%

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Emerging investigator series: metal nanoparticles in freshwater: transformation, bioavailability and effects on invertebrates

Wang

Liu

2022

Environ. Sci.: Nano

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“…[17] Biomarkers of oxidative stress include malondialdehyde (MDA) (polyunsaturated fatty acid peroxidation and hence considered a meaningful sign of lipid peroxide) and [22] catalase (CAT) (a vital component of the antioxidant defence system that supports each other and provides a protective defence against ROS). [23] One of the primary antioxidant cellular defence systems is the hexose monophosphate (HMP) pathway. [24] The relationship between GSH metabolism and the HMP pathway protects cells against oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress markers as early predictors of diabetes complications in Type 2 diabetic patients

Abdel-Raheem

Hamed

Fahim

et al. 2022

IJPP

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Objectives: Type 2 diabetes mellitus (T2DM) is a complex disease that affects many organs. Oxidative stress plays a key role in the pathogenesis of insulin resistance and β-cell dysfunction. Thus, the present study aimed to use oxidative stress markers as early predictors for the progression of diabetic complications. Materials and Methods: The study sample included 400 individuals (300 T2DM and 100 non-diabetic controls) aged from 35 to 59 years randomly selected from the outpatient clinic of the National Institute for Diabetes and Endocrinology. T2DM patients were divided into subgroups: Subgroup (1) patients without any complications, Subgroup (2) patients with diabetic nephropathy (DN) and Subgroup (3) patients with cardiovascular disorders (CVD). Biochemical markers of fasting blood glucose, glycated haemoglobin (HbA1C), glucose-6-phosphate dehydrogenase (G6PD), lactate, arginase, heme oxygenase-1 (HO-1), haemoglobin (Hb), triglycerides (TG), cholesterol, low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), urea, creatinine, malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT) and nitric oxide (NO) were performed. Results: DM patients showed significant increases in body mass index, systolic blood pressure, diastolic blood pressure, FBS, HbA1C, cholesterol, TG, LDL-C and glomerular filtration rate, while HDL-C decreased. Significant increases were observed in HO-1, MDA and NO, while G6PD/lactate, GSH and CAT decreased in DM patients. The DN and CVD patients exhibited a significant increase in HO-1, MDA and NO; while G6PD/lactate, GSH and CAT decreased compared with DM patients. Receiver operating characteristic analysis showed that the sensitivity and specificity of oxidative stress markers were 66.67–100%. Conclusion: Hexose monophosphate (HMP)/glycolysis pathways are shifted during DM near glycolysis rather than HMP pathway to produce energy where the amount of glucose enters the cells is low, causing oxidative stress. Oxidative stress markers could be used as early predictors of diabetes complications.

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“…Green silver nanoparticle syntheses have recently gotten much attention because they are clean, eco-friendly, cost-effective and easy to scale up [19][20][21][22] . Nanocomposites are highperformance composites in which at least one of the phases shows dimensions in the nanometer range (1 nm = 10G 9 m) 23 . Incorporating a small concentration of nanoparticles into a Nanocomposite is expected to provide maximum antibacterial properties and minimal toxicity.…”

Section: Introductionmentioning

confidence: 99%

Silver/Chitosan/Ascorbic Acid Nanocomposites Attenuates Bacterial Sepsis in Cecal Ligation and Puncture Rat Model

Moha¹,

Al-Quraish²,

Abdel-Gabe³

et al. 2021

International J. of Pharmacology

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Background and Objective: Sepsis is a universal that represents a physiologic, pathologic and biochemical abnormalities disorder stimulated by infection. The present study aimed to synthesize and apply silver/chitosan/ascorbic acid Nanocomposites (Ag-CS-AA NC) on septic rats induced by cecal ligation and puncture. Materials and Methods: The synthesized Ag-CS-AA NC were characterized by UV-visible spectroscopy, XRD, XPS, FTIR and TEM. H 2 O 2 scavenging and antibacterial activities of Ag-CS-AA NC were analyzed. Eighteen rats were randomly divided into three groups: Sham group, CLP-induced sepsis and septic rats treated with Ag-CS-AA NC. Results: The synthesized Ag-CS-AA NC showed in vitro potent antioxidant and antibacterial activities against Gram-positive and Gram-negative bacteria. Ag-CS-AA NC administration to septic rats showed a reduction in alanine aminotransferases, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyltransferase and concentrations of total proteins, albumin, creatinine, urea, uric acid, nitric oxide, while glutathione reduced and catalase increased. The histopathological investigation showed clear improvement in the hepatic and kidney architecture. Conclusion: The data provide the first experimental demonstration that green synthesize Ag-CS-AA NC has a therapeutic effect against sepsis-induced liver and kidney damage through its antibacterial and antioxidant activities.

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Silver/chitosan nanocomposites induce physiological and histological changes in freshwater bivalve

Cited by 7 publications

References 49 publications

Emerging investigator series: metal nanoparticles in freshwater: transformation, bioavailability and effects on invertebrates

Emerging investigator series: metal nanoparticles in freshwater: transformation, bioavailability and effects on invertebrates

Oxidative stress markers as early predictors of diabetes complications in Type 2 diabetic patients

Silver/Chitosan/Ascorbic Acid Nanocomposites Attenuates Bacterial Sepsis in Cecal Ligation and Puncture Rat Model

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