Silver‐Catalyzed Asymmetric Double Desymmetrization via Vinylogous Michael Addition of Prochiral α,α‐Dicyanoalkenes to Cyclopentendiones
Kavita Choudhary,
Harshit Joshi,
Shweta Rohilla
et al.
Abstract:An asymmetric double desymmetrization methodology has been developed for synthesizing densely functionalized chiral cyclopentylcyclohexane scaffolds. We have constructed four chiral centers, including an all‐carbon quaternary stereocenter in a single C‐C bond formation event. The methodology has high functional‐group tolerance and delivers a broad range of enantioenriched products. This vinylogous Michael addition reaction of prochiral α,α‐dicyanocyclohexane to 2,2‐disubstituted cyclopentene‐1,3‐dione is catal… Show more
We report the first metal-catalyzed (2+4) annulation of 5-alkenyl thiazolones and dicyanoalkylidenes, delivering spiro[cyclohexenamines-thiazolones] with high stereoselectivities.
We report the first metal-catalyzed (2+4) annulation of 5-alkenyl thiazolones and dicyanoalkylidenes, delivering spiro[cyclohexenamines-thiazolones] with high stereoselectivities.
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