Silver bullets: A new lustre on an old antimicrobial agent

Möhler, Jasper S.; Sim, Wen Jing; Blaskovich, Mark A. T.; Cooper, Matthew A.; Ziora, Zyta M.

doi:10.1016/j.biotechadv.2018.05.004

Cited by 133 publications

(93 citation statements)

References 171 publications

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“…The mechanism, which silver acts is through the release of positively charged Ag ions that bind the wall of the bacterium causing cell wall disruption, deactivation of enzymes and causing changes in membrane permeability . It is believed that the differential of the nanoparticles is given by their greater surface area that allows a stronger interaction in the therapeutic sites, besides its smaller size to facilitate penetration through the biological membranes . The junction of these mechanisms would have functioned synergistically for AgNP‐P activity.…”

Section: Resultsmentioning

confidence: 99%

“…56 It is believed that the differential of the nanoparticles is given by their greater surface area that allows a stronger interaction in the therapeutic sites, besides its smaller size to facilitate penetration through the biological membranes. 57 The junction of these mechanisms would have functioned synergistically for AgNP-P activity.…”

Section: Antibacterial Evaluationmentioning

confidence: 99%

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Biogenic synthesis of silver nanoparticles using Brazilian propolis

Barbosa

Souza

Alvino

et al. 2019

Biotechnology Progress

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Biological methods have been used to synthesize silver nanoparticles through materials such as bacteria, fungi, plants, and propolis due to their reducing properties, stabilizer role and environmentally friendly characteristic. Considering the antimicrobial activity of propolis as well as the broad‐spectrum antibacterial effects of silver nanoparticles, this study aim to describe the use of Brazilian propolis to synthesize silver nanoparticles (AgNP‐P) and investigate its antimicrobial activity. The synthesis was optimized by factorial design, choosing the best conditions for smaller size particles. AgNP‐P demonstrated a maximum absorbance at 412 nm in ultraviolet‐visible spectra, which indicated a spherical format and its formation. Dynamic light scattering demonstrated a hydrodynamic size of 109 nm and polydispersity index less than 0.3, showing a good size distribution and stability. After its purification via centrifugation, microscopy analysis corroborates the format and showed the presence of propolis around silver nanoparticle. X‐ray diffraction peaks were attributed to the main planes of the metallic silver crystalline structure; meanwhile infrared spectroscopy demonstrated the main groups responsible for silver reduction, represented by ∼22% of AgNP‐P indicates by thermal analysis. Our product revealed an important antimicrobial activity indicating a synergism between propolis and silver nanoparticles as expected and promising to be an effective antimicrobial product to be used in infections.

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Section: Resultsmentioning

confidence: 99%

Section: Antibacterial Evaluationmentioning

confidence: 99%

Biogenic synthesis of silver nanoparticles using Brazilian propolis

Barbosa

Souza

Alvino

et al. 2019

Biotechnology Progress

View full text Add to dashboard Cite

show abstract

“…The study of silver nanoparticles (AgNPs), has undergone a breakthrough in recent decades, mainly due to their optical [1,2] and antimicrobial properties [3][4][5][6]. AgNPs can be prepared by Materials 2020, 13, 503 2 of 17 means of physical, chemical, electrochemical and biological methods [7,8].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Mimosa albida (Mimosoideae): Characterization and Antioxidant Activity

et al. 2020

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The search for sensitive and rapid analytical techniques for the determination of natural antioxidants is an area in constant growth due, among other aspects, to the complexity of plant matrices. In this study, silver nanoparticles prepared with the aqueous extract of Mimosa albida leaves were used to assess their polyphenolic content and antioxidant capacity. Silver nanoparticles were characterized by different techniques. As a result, nanoparticles of 6.5 ± 3.1 nm were obtained. The total phenolic content in the extract was 1320.4 ± 17.6 mg of gallic acid equivalents GAE· 100 g−1 and in the nanoparticles 257.3 ± 5.1 mg GAE· 100 g−1. From the phenolic profile analyzed by ultra high-performance liquid chromatography (UPLC) with a diode-array detector (DAD), the presence of apigenin and luteolin in the plant extract is postulated. The antioxidant capacity measured by oxygen radical absorbance capacity ORAC-fluorescein assay was 86917 ± 6287 and 7563 ± 967 µmol ET g−1 in the extract and nanoparticles respectively. Electrochemical analysis by cyclic voltammetry (CV) confirmed the effective reduction capacity of the Mimosa albida leaves extract to reduce Ag ions to AgNPs and differential pulse voltammetry (DPV) suggested the presence of two main reducing agents in the extract. From this study, it was concluded that the aqueous extract of Mimosa albida contains reducing agents capable of synthesizing silver nanoparticles, which can be used in the phytochemical industry.

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“…attachment of a biocide) to the surface. The biocidal properties of copper, zinc and silver (amongst other metals) are exploited in commercial antimicrobial additives and in ongoing research 5 , with silver a well-established choice. We therefore chose to develop a composite material to be used in AM using silver-based additives.…”

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confidence: 99%

Use of silver-based additives for the development of antibacterial functionality in Laser Sintered polyamide 12 parts

Turner

Wingham

Paterson

et al. 2020

Sci Rep

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Infectious diseases (exacerbated by antimicrobial resistance) cause death, loss of quality of life and economic burden globally. Materials with inherent antimicrobial properties offer the potential to reduce the spread of infection through transfer via surfaces or solutions, or to directly reduce microbial numbers in a host if used as implants. Additive Manufacturing (AM) techniques offer shorter supply chains, faster delivery, mass customisation and reduced unit costs, as well as highly complicated part geometries which are potentially harder to clean and sterilise. Here, we present a new approach to introducing antibacterial properties into AM, using Laser Sintering, by combining antimicrobial and base polymer powders prior to processing. We demonstrate that the mechanical properties of the resultant composite parts are similar to standard polymer parts and reveal the mode of the antibacterial activity. We show that antibacterial activity is modulated by the presence of obstructing compounds in different experimental media, which will inform appropriate use cases. We show that the material is not toxic to mammalian cells. This material could be quickly used for commercial products, and our approach could be adopted more generally to add new functionality to Laser Sintered parts. The global Additive Manufacturing (AM) market has grown by an average of 26.9% annually for the last 30 years, with the overall revenue of the industry currently estimated at $9.8 billion, and aerospace, automotive and healthcare being major sectors 1. Parts are produced in a layer-by-layer manner, directly from a Computer-Aided Design (CAD) file. This layer-by-layer approach provides key benefits through removing the need for tooling and increasing the ease with which complex geometries can be produced. However, despite their clear potential, the range of materials that can be used in AM processes is limited compared to more traditional manufacturing techniques, which in turn has restricted the range of applications in which they can be used. Laser Sintering is an AM technology that produces parts by selectively scanning and melting consecutive cross-sections of polymer powder particles. Areas which have not been scanned remain as loose powder throughout the process, acting to support any overhanging areas, which in turn allows the economic production of highly complex part geometries. This geometric capability makes Laser Sintering highly suited to production of complex, optimised, products and devices, or to the production of products and devices personalised to individuals. However, particularly when considering hand-held and/or medical products, increasing geometric complexity can render them difficult and time-consuming to clean effectively, potentially providing increased chance of spread of bacteria. Incorporation of antibacterial properties into the parts themselves could reduce or eliminate this risk, and is the focus of this work. Many antimicrobial products are currently available to purchase, with a growing global market fo...

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Silver bullets: A new lustre on an old antimicrobial agent

Cited by 133 publications

References 171 publications

Biogenic synthesis of silver nanoparticles using Brazilian propolis

Biogenic synthesis of silver nanoparticles using Brazilian propolis

Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Mimosa albida (Mimosoideae): Characterization and Antioxidant Activity

Use of silver-based additives for the development of antibacterial functionality in Laser Sintered polyamide 12 parts

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