Silver-based coordination polymers assembled by dithioether ligands: potential antibacterial materials despite received ideas

Abstract

We report on the first examples on the antibacterial activity towards Gram-negative and Gram-positive bacteria of 2D silver-based coordination polymers obtained by self-assembly with acetylenic dithioether ligands. Their structure imparts...

Synthesis of Organosilicon‐Based Thioether Ligand Class Showing Defined S‐Stereogenic Coordination in Crystalline Palladium(II) Complexes

“…2 a crystallizes in the monoclinic crystal system, space group C2/c, from ethanol at À 30 °C as large, colourless needles. The silicon and sulphur atoms and the naphthyl rest are nearly coplanar [C4-S1-C5-C6 5.76 (10)°and Si1-C4-S1-C5 176.77( 6)°]. The crystallographic data and parameters for the structural refinement of all solid-state structures are compiled in Table 1.…”

“…plane of the complex [C5-S1-Pd1-Cl1 84.46(5)°]. The torsion angle C4-S1-C5-C6 21.18 (10)°indicates that the aromatic moiety is rotated out of the plane, comparable to the naphthyl group in 3 a. But the trimethylsilyl substituent is not drastically rotated out of the plane with a torsion angle of C5-S1-C4-Si1 174.36 (7)…”

“…Sulphane compounds are an important ligand class for complexation in transition metal coordination chemistry. [1][2][3][4][5][6][7][8][9][10] Their palladium(II) complexes are known to promote hydrolysis of oligopeptides with outstanding regioselectivity or co-polymerize alternating carbon monoxide and tert-butylstyrene. [11,12] The complex properties of this class are often determined by the substituents of the sulphur centre.…”

Polymeric CuX coordination compounds assembled from acetylenic thioether ligands RSCH2CCCH2R (R = C6H11, t-Bu): effect of the RS-group, halide and stoichiometry on the network architecture and the luminescence properties

“…The facile and low-cost preparation of these air stable (over several months) compounds even in a gram-scale make them also promising candidates for applications in material sciences. We are currently extending the coordination chemistry of this type of acetylenic ligands to other metal centres such as Ag( i ) salts generating networks displaying an antibacterial activity 68 or Hg( ii ) salts. The post-functionalisation of the reactive triple bonds by addition reaction across the reactive triple bonds (hydrothiolation, hydrosilylation, click-reaction with organic azides, etc. )…”

A Kinetic Approach to Synergize Bactericidal Efficacy and Biocompatibility in Silver-Based Sol–Gel Coatings

“…Although the mechanism of the bactericidal action of Ag-based compounds or Ag + cations remains unclear, a few hypotheses have emerged in the recent literature. A common consensus suggests that exposure to Ag + cations disrupts the bacterial membrane, leading to the leakage of cytoplasm and intracellular contents. , This membrane disruption is often attributed to the strong interactions of Ag + cations with the constituents of bacterial membranes, primarily through interactions with thiol groups of membrane enzymes or proteins …”