Silver bands in chronic granulocytic leukemia: I. Increased banding associated with blastic transformation

Brasch, J. M.; O'Malley, F. M.; Garson, O. Margaret; Smyth, David

doi:10.1016/0165-4608(84)90099-2

Cited by 9 publications

(1 citation statement)

References 11 publications

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“…A decrease of the NOR activity as a func tion of age has also been described, with a marked decline in more advanced ages [24,25], Similarly, changes in NOR activity in leu kemias associated as much with the stage of the disease as with the tissue investigated (bone marrow and lymphocytes) have been reported [26,27], These changes in Ag NOR stainability were also verified in other neopla sias. During the past few years, Ag NOR pro teins have been regularly used to evaluate nucleolar activity and cell proliferation and have been one criterion for the diagnosis of cancer cells [28].…”

Section: Resultsmentioning

confidence: 64%

Reduction of the Activity of Ribosomal Genes with Age in Down’s Syndrome

Borsatto

Smith²

1996

Gerontology

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The hypothesis of the coparticipation of ribosomal genes in controlling the differential expression of genes with age is analyzed in Down’s syndrome. The activity of ribosomal genes was tested cytogenetically by Ag-stained nucleolar organizer regions and by satellite association in lymphocytes from 40 patients with Down’s syndrome. Twenty patients were between 0 and 25 years old, and the others were between 29 and 48 years old. Our results showed a significant decrease with regard to total Ag staining and in relation to each chromosome pair in the older Down’s syndrome group as compared with the younger group. The total number of associated chromosomes and the number of associations of each chromosome pair were both significantly lower. The results show a decreased activity of ribosomal genes with age. This reduction may originate from changes in regulation and expression of these genes that might result in differing cell translation ability.

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Section: Resultsmentioning

confidence: 64%

Reduction of the Activity of Ribosomal Genes with Age in Down’s Syndrome

Borsatto

Smith²

1996

Gerontology

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Differential nucleolus organizer activity in normal and leukemic bone marrow

et al. 1989

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A cytochemical technique that uses silver nitrate staining has been used to study the nucleolus organizer activity in bone marrow cells from 13 patients with acute lymphocytic leukemia (ALL), 11 patients with chronic myelogenous leukemia (CML), 7 patients with acute myelogenous leukemia (AML), and 4 healthy persons. Our results indicate that the nucleolus organizer region (NOR) activity was significantly lower in the control group than in the ALL patients. The NOR activity level was significantly lower in both the CML patients in chronic phase and the AML patients than in the ALL group and similar to the control group. These disease-related differences in NOR activity as detected by silver staining can be used as diagnostic procedure in evaluating human leukemias.

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Ag‐Nor staining in human chromosomes: Differential staining in normal and leukemic bone‐marrow samples

Arden¹,

Pathak²,

Frankel³

et al. 1985

Intl Journal of Cancer

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A silver staining technique developed by Goodpasture and Bloom (1975) stains a specific protein associated with the activity of ribosomal cistrons during the preceding interphase. By counting the number of chromosomes with darkly stained nucleolus organizer regions (NORs), the number of active NORs per metaphase can be determined. A comparison of NOR activity in bone-marrow cells from leukemic patients in different stages of disease with that of bone marrow from normal, healthy individuals was conducted and differential NOR activity was detected. The control group showed significantly lower NOR activity when compared with a group of patients with acute lymphocytic leukemia (ALL). These preliminary data indicate that this simple cytochemical technique can be effectively used to differentiate between normal and ALL bone-marrow samples.

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Silver bands in chronic granulocytic leukemia: I. Increased banding associated with blastic transformation

Cited by 9 publications

References 11 publications

Reduction of the Activity of Ribosomal Genes with Age in Down’s Syndrome

Reduction of the Activity of Ribosomal Genes with Age in Down’s Syndrome

Differential nucleolus organizer activity in normal and leukemic bone marrow

Ag‐Nor staining in human chromosomes: Differential staining in normal and leukemic bone‐marrow samples

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